Antagonist Peptide Selects Thymocytes Expressing a Class II Major Histocompatibility Complex–restricted T Cell Receptor into the CD8 Lineage

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Positive Selection of Thymocytes

1995 • 604 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Essential flexibility in the T-cell recognition of antigen

1996 • 330 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Identification of a Naturally Occurring Ligand for Thymic Positive Selection

1997 • 193 citations

The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide–MHC Molecule Ligands

1997 • 183 citations

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

1993 • 156 citations

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.

1989 • 151 citations

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

1996 • 141 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

Selection of a Broad Repertoire of CD4+ T Cells in H-2Ma0/0 Mice

1997 • 122 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Surface Molecules That Drive T Cell Development In Vitro in the Absence of Thymic Epithelium and in the Absence of Lineage-Specific Signals

1997 • 110 citations

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

1997 • 108 citations

Specific Recognition of Thymic Self-Peptides Induces the Positive Selection of Cytotoxic T Lymphocytes

1997 • 95 citations

A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes.

1994 • 86 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of T Cell Receptor Specificity

1998 • 59 citations

Functional recognition of in vivo processed self antigen

1994 • 53 citations

Permissive recognition during positive selection

1996 • 52 citations

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus

1997 • 51 citations

The influence of invariant chain on the positive selection of single T cell receptor specificities

1995 • 49 citations

Processing of endogenously synthesized hen egg-white lysozyme retained in the endoplasmic reticulum or in secretory form gives rise to a similar but not identical set of epitopes recognized by class II-restricted T cells.

1993 • 45 citations

Cell-surface markers on haemopoietic precursors. Reagents for the isolation and analysis of progenitor cell subpopulations

1987 • 43 citations

Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: Rescue of CD4 T cell lineage without co‐engagement of TcR/CD4 by MHC class II

1995 • 19 citations

CD4+/CD8- thymocytes dominate the fetal thymus treated with a combination of anti-T cell receptor-beta and anti-CD4 antibodies.

1993 • 7 citations

M. V. Keldysh

1978 • 1 citations