MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Current protocols in immunology

1992 • 1,464 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

A monoclonal antibody discriminating between subsets of T and B cells.

1981 • 565 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Selective Events in T Cell Development

1994 • 486 citations

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

1991 • 419 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

Mice lacking major histocompatibility complex class I and class II molecules.

1993 • 259 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1993 • 201 citations

The NK-1.1(-) mouse: a model to study differentiation of murine NK cells.

1986 • 165 citations

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

1992 • 159 citations

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

1993 • 156 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

1996 • 141 citations

The majority of CD4+8- thymocytes are functionally immature.

1991 • 137 citations

Helper T-cell development in the absence of CD4-p56 Ick association

1993 • 132 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection

1994 • 112 citations

Positive selection of T cells

1995 • 106 citations

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

1995 • 104 citations

Class II major histocompatibility complex‐restricted T cell function in CD4‐deficient mice

1994 • 102 citations

The selection of the α,β heterodimeric T-cell receptor for antigen

1986 • 100 citations

Development of Mature CD8⁺Thymocytes: Selection Rather Than Instruction?

1993 • 94 citations

Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes.

1992 • 90 citations

Antigen-induced lymphomagenesis: identification of a murine B cell lymphoma with known antigen specificity.

1983 • 89 citations

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity

1994 • 77 citations

Evidence for differential intracellular signaling via CD4 and CD8 molecules.

1994 • 69 citations

Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen

1982 • 63 citations

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.

1993 • 62 citations

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice.

1994 • 59 citations

Stochastic component to development of class I major histocompatibility complex-specific T cells.

1994 • 54 citations

Role of coreceptors in positive selection and lineage commitment.

1994 • 49 citations

The structure of Vα and Jα segments in the mouse

1988 • 41 citations

Role of TCR specificity in CD4 versus CD8 lineage commitment.

1995 • 39 citations

A human CD4 transgene rescues CD4⁻CD8⁺ cells in β2‐microglobulin‐deficient mice

1994 • 35 citations

Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage.

1994 • 18 citations