The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.

1991 • 874 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

Immunochemistry on ultrathin frozen sections

1980 • 755 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

The retention signal for soluble proteins of the endoplasmic reticulum

1990 • 531 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

The Golgi complex: In vitro veritas?

1992 • 481 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum

1992 • 396 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes

1987 • 322 citations

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation

1989 • 317 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Role of ATP and disulphide bonds during protein folding in the endoplasmic reticulum

1992 • 286 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

On the complexity of self

1991 • 261 citations

The binary logic of antigen processing and presentation to T cells

1990 • 235 citations

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain.

1986 • 226 citations

The endoplasmic reticulum—Golgi intermediate compartment

1992 • 224 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

A role of la-associated invariant chains in antigen processing and pressentation

1989 • 184 citations

Purificaton of a functional mouse Fc receptor through the use of a monoclonal antibody.

1980 • 173 citations

Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.

1990 • 156 citations

Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme.

1991 • 155 citations

Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens.

1990 • 149 citations

Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers.

1993 • 145 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain.

1986 • 142 citations

Invariant chain influences the immunological recognition of MHC class II molecules

1990 • 127 citations

Monoclonal antibody detection of a major self peptide. MHC class II complex.

1992 • 127 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes.

1993 • 113 citations

Intracellular traffic and antigen processing

1989 • 92 citations

Endocytosis and recycling of specific antigen by human B cell lines.

1988 • 89 citations

Cellular mechanisms of antigen processing and the function of class I and II major histocompatibility complex molecules.

1990 • 60 citations

The function of the invariant chain in antigen presentation by MHC class II molecules

1990 • 44 citations

Identification, molecular characterization and immunolocalization of an isoform of the trans-Golgi-network (TGN)-specific integral membrane protein TGN38

1992 • 37 citations

Changing the specificity of the sorting receptor for luminal endoplasmic reticulum proteins

1992 • 28 citations