TCR transgenic mice in which usage of transgenic alpha- and beta-chains is highly dependent on the level of selecting ligand.

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

1979 • 1,885 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

Control points in early T-cell development

1993 • 429 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice

1994 • 305 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands.

1996 • 208 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.

1991 • 190 citations

The murine Eα immune response gene

1983 • 180 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

Th2 cell clonal anergy as a consequence of partial activation.

1994 • 175 citations

Essential Role of the Pre-T Cell Receptor in Allelic Exclusion of the T Cell Receptor β Locus

1997 • 146 citations

Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion.

1995 • 132 citations

Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas.

1992 • 131 citations

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes

1993 • 130 citations

The effects of MHC gene dosage and allelic variation on T cell receptor selection

1990 • 123 citations

Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.

1996 • 121 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

A Novel Mechanism for B Cell Repertoire Maturation Based on Response by B Cell Precursors to Pre–B Receptor Assembly

1998 • 110 citations

Dual T cell receptor beta chain expression on human T lymphocytes.

1995 • 106 citations

The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized.

1988 • 86 citations

Evidence for a single-niche model of positive selection.

1994 • 76 citations

Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells.

1995 • 71 citations

Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation

1995 • 48 citations

Is TCR β expression an essential event in early thymocyte development?

1993 • 27 citations

Structurally similar TCRs differ in their efficiency of positive selection.

1997 • 13 citations