p53-Oriented cancer therapies: Current progress

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

1997 • 872 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies

1996 • 666 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Gene Therapy for Cancer: What Have We Done and Where Are We Going?

1997 • 635 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

1993 • 514 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

p53 in growth control and neoplasia

1996 • 488 citations

Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy

1995 • 458 citations

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

1994 • 453 citations

Two cellular proteins that bind to wild-type but not mutant p53.

1994 • 423 citations

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

1995 • 421 citations

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

1995 • 409 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Cell-cycle arrest versus cell death in cancer therapy

1997 • 394 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

mdm-2 Inhibits the G₁ Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

1996 • 354 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1997 • 346 citations

A Novel Three-Pronged Approach to Kill Cancer Cells Selectively: Concomitant Viral, Double Suicide Gene, and Radiotherapy

1998 • 337 citations

p53 in signaling checkpoint arrest or apoptosis

1996 • 336 citations

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.

1996 • 318 citations

Evidence for a second cell cycle block at G2/M by p53.

1995 • 306 citations

Intercellular delivery of functional p53 by the herpesvirus protein VP22

1998 • 285 citations

Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways.

1995 • 282 citations

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.

1992 • 272 citations

p53 in hematologic malignancies

1994 • 269 citations

Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines.

1996 • 262 citations

Implications of the p53 tumor-suppressor gene in clinical oncology.

1995 • 258 citations

Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer.

1998 • 242 citations

Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer.

1992 • 237 citations

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

1997 • 234 citations

p53-dependent cell death/apoptosis is required for a productive adenovirus infection

1998 • 231 citations

P53 tumor suppressor gene therapy for cancer.

1998 • 220 citations

Tumor Eradication by Wild-type p53-specific Cytotoxic T Lymphocytes

1997 • 215 citations

Therapeutic Effect of a Retroviral Wild-Type p53 Expression Vector in an Orthotopic Lung Cancer Model

1994 • 214 citations

p53; from inductive signal to cellular effect

1997 • 214 citations

p53 in hematologic malignancies

1994 • 206 citations

The Physical Association of Multiple Molecular Chaperone Proteins with Mutant p53 Is Altered by Geldanamycin, an hsp90-Binding Agent

1998 • 206 citations

CLINICAL IMPLICATIONS OF THE p53 GENE

1996 • 200 citations

Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions.

1992 • 200 citations

A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis

1994 • 195 citations

Cancer therapy and p53

1995 • 194 citations

In vitro and in vivo targeting of gene expression to melanoma cells.

1993 • 190 citations

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

1995 • 185 citations

Important advances in oncology 1996

1997 • 184 citations

Relationship of p53 to the control of apoptotic cell death.

1994 • 163 citations

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

1992 • 161 citations

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

1998 • 161 citations

p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel.

1997 • 148 citations

Systemic Gene Therapy with p53 Reduces Growth and Metastases of a Malignant Human Breast Cancer in Nude Mice

1995 • 145 citations

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies.

1996 • 140 citations

Parenteral Gene Therapy with p53 Inhibits Human Breast TumorsIn VivoThrough a Bystander Mechanism Without Evidence of Toxicity

1997 • 138 citations

A temperature-sensitive mutant of human p53.

1994 • 128 citations

MDM2-arbiter of p53's destruction

1997 • 127 citations

The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle

1997 • 127 citations

Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2.

1996 • 127 citations

p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge.

1996 • 123 citations

Stable Expression of the Wild-Typep53Gene in Human Lung Cancer Cells after Retrovirus-Mediated Gene Transfer

1993 • 121 citations

Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer and Other Diseasesa

1994 • 119 citations

Maintaining genetic stability through TP53 mediated checkpoint control.

1997 • 117 citations

Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumours - evaluation of a potentially effective clinical therapy

1996 • 115 citations

Efficacy of p53 adenovirus-mediated gene therapy against human breast cancer xenografts.

1997 • 113 citations

The humoral response to the tumor-suppressor gene-product p53 in human cancer: implications for diagnosis and therapy

1996 • 109 citations

Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance.

1996 • 108 citations

Cisplatin- and paclitaxel-induced apoptosis of ovarian carcinoma cells and the relationship between bax and bak up-regulation and the functional status of p53.

1998 • 99 citations

Heat shock induces transient p53-dependent cell cycle arrest at G1/S

1997 • 99 citations

Abrogation of p53 Function Affects gadd Gene Responses to DNA Base-Damaging Agents and Starvation

1996 • 98 citations

Transferrin–Liposome-Mediated p53 Sensitization of Squamous Cell Carcinoma of the Head and Neck to Radiation In Vitro

1997 • 91 citations

Structure–based rescue of common tumor–derived p53 mutants

1996 • 90 citations

Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.

1998 • 86 citations

Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53.

1995 • 85 citations

Oligonucleotide‐mediated modulation of mammalian gene expression ¹

1995 • 80 citations

p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.

1998 • 73 citations

Effective Treatment of Early Endobronchial Cancer With Regional Administration of Liposome-p53 Complexes

1998 • 70 citations

Induction of apoptosis by p53 is independent of its oligomeric state and can be abolished by HPV-18 E6 through ubiquitin mediated degradation.

1996 • 69 citations

Idiotypic immunization induces immunity to mutated p53 and tumor rejection

1998 • 65 citations

Evidence for selection against human lung cancers bearing p53 missense mutations which occur within the HLA A*0201 peptide consensus motif.

1994 • 62 citations

High efficiency gene transfer to the central nervous system of rodents and primates using herpes virus vectors lacking functional ICP27 and ICP34.5

1998 • 59 citations

Intracavitary Liposome-Mediated p53 Gene Transfer into Glioblastoma with Endogenous Wild-Type p53in VivoResults in Tumor Suppression and Long-Term Survival

1997 • 55 citations

p53 induces angiogenesis-restricted dormancy in a mouse fibrosarcoma

1998 • 54 citations

An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutants.

1996 • 53 citations

Geldanamycin Prevents Nuclear Translocation of Mutant p53

1997 • 52 citations

Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression

1995 • 52 citations

Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53

1994 • 51 citations

Adenovirus-mediated wild-type p53 overexpression inhibits endothelial cell differentiation in vitro and angiogenesis in vivo

1998 • 51 citations

p53: DNA damage, DNA repair, and apoptosis

1995 • 50 citations

The dominating effect of mutant p53

1995 • 48 citations

Selective Cytotoxicity to Human Leukemic Myeloblasts Produced by Oligodeoxyribonucleotide Phosphorothioates Complementary to p53 Nucleotide Sequences

1994 • 48 citations

Preliminary report: the short-term effects of direct p53 DNA injection in primary hepatocellular carcinomas.

1996 • 47 citations

Converting cancer genes into killer genes.

1996 • 46 citations

p53 Gene Mutation Analysis and Antisense-Mediated Growth Inhibition of Human Ovarian Carcinoma Cell Lines

1996 • 42 citations

p53 and response to chemotherapy and radiotherapy.

1996 • 40 citations

TP53 tumour suppressor gene: clues to molecular carcinogenesis and cancer therapy.

1996 • 38 citations

Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA.

1995 • 34 citations

Bypass of abnormal MDM2 inhibition of p53-dependent growth suppression.

1998 • 33 citations

CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties.

1998 • 33 citations

p53/E1b58kDa Complex Regulates Adenovirus Replication

1997 • 32 citations

Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle.

1994 • 30 citations

Ex Vivo Treatment of Bone Marrow with Phosphorothioate Oligonucleotide OL(l)p53 for Autologous Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndrome

1997 • 30 citations

HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence.

1996 • 27 citations

P53 as a target for anti-cancer immunotherapy

1997 • 26 citations

Post-translational modification of p53 and the integration of stress signals.

1997 • 24 citations

Modification of Tumor Suppressor Gene Expression in Non-Small Cell Lung Cancer (NSCLC) with a Retroviral Vector Expressing Wildtype (normal) p53. University of Texas M.D. Anderson Cancer Center, Houston, Texas

1996 • 21 citations

Therapeutic targeting of the p53 tumor suppressor gene

1996 • 21 citations

Cytotoxic T lymphocyte responses to wild‐type and mutant mouse p53 peptides

1997 • 21 citations

Combination Anti-Gene Therapy Targeting c-myc and p53 in Ovarian Cancer Cell Lines

1995 • 19 citations

Mutant Oncopeptide Immunization Induces CTL Specifically Lysing Tumor Cells Endogenously Expressing the Corresponding Intact Mutant p53

1995 • 16 citations

p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel. Cancer Res.

1997 • 16 citations

Gene Therapy for Liver Tumours

2002 • 9 citations

Hepatocellular carcinoma and p53 gene therapy

1996 • 8 citations

p53: A target for new anticancer drugs or a target for old drugs?

1993 • 5 citations