Bypass of abnormal MDM2 inhibition of p53-dependent growth suppression.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Cancer Cell Cycles

1996 • 5,379 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

p53 function and dysfunction

1992 • 1,918 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1995 • 592 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

mdm-2 Inhibits the G₁ Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

1996 • 354 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

The human MDM-2 oncogene is overexpressed in leukemias

1993 • 253 citations

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1997 • 236 citations

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

1996 • 234 citations

Proteasome-Dependent Regulation of p21WAF1/CIP1Expression

1996 • 223 citations

Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.

1997 • 208 citations

In vitro evaluation of ap53-expressing adenovirus as an anti-cancer drug

1996 • 202 citations

The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo

1995 • 182 citations

The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin

1994 • 164 citations

Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines.

1995 • 162 citations

Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells.

1994 • 145 citations

Physical and functional interaction between wild-type p53 and mdm2 proteins.

1994 • 135 citations

Effects of a recombinant adenovirus expressing WAF1/Cip1 on cell growth, cell cycle, and apoptosis.

1995 • 77 citations

Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells.

1997 • 66 citations

MDM2 gene amplification in human breast cancer

1994 • 66 citations

p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma.

1995 • 54 citations