Gene Therapy for Liver Tumours

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

The multistep nature of cancer

1993 • 1,872 citations

Tumor Suppressor Genes

1991 • 1,784 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Gene Therapy for Cancer: What Have We Done and Where Are We Going?

1997 • 635 citations

Chromosome Aberrations and Cancer

1991 • 598 citations

Prospects for Human Gene Therapy

1984 • 548 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

1990 • 413 citations

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

1993 • 380 citations

Abrogation of p53-Induced Apoptosis by the Hepatitis B Virus X Gene

2003 • 318 citations

Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas.

1995 • 313 citations

Clinical short-term results of radiofrequency ablation in primary and secondary liver tumors

1999 • 235 citations

Cancer Detection and Prevention.

1977 • 220 citations

Carcinogenicity studies on halogenated hydrocarbons.

1977 • 194 citations

Viral vector systems for gene therapy.

1994 • 193 citations

p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan.

1997 • 172 citations

In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.

1997 • 170 citations

p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China.

1992 • 161 citations

Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter.

1995 • 153 citations

Liver metastases: results of percutaneous ethanol injection in 14 patients.

1991 • 153 citations

Surgical options in the treatment of hepatic metastasis from colorectal cancer

1995 • 136 citations

Retinoblastoma and p 53 tumor suppressor genes in human hepatoma cell lines

1993 • 128 citations

Phase I Study of Direct Administration of a Replication Deficient Adenovirus Vector Containing theE. coliCytosine Deaminase Gene to Metastatic Colon Carcinoma of the Liver in Association with the Oral Administration of the Pro-Drug 5-Fluorocytosine. The New York Hospital-Cornell Medical Center, New York, NY

1997 • 120 citations

Tumor suppressor genes, growth factor genes, and oncogenes in hepatitis B virus‐associated hepatocellular carcinoma

1994 • 119 citations

Tumour suppressor genes

1992 • 117 citations

Gene therapy for ?-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene

1996 • 114 citations

Adenovirus-mediated p53 gene transfer inhibits growth of human tumor cells expressing mutant p53 protein.

1996 • 114 citations

Alcohol and Cancer

1998 • 109 citations

p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation

1998 • 105 citations

Surgical resection for small hepatocellular carcinoma

1996 • 97 citations

Hammerhead Ribozyme-Mediated Inhibition of Telomerase Activity in Extracts of Human Hepatocellular Carcinoma Cells

1996 • 95 citations

Selective Killing of AFP-Positive Hepatocellular Carcinoma Cells by Adeno-Associated Virus Transfer of the Herpes Simplex Virus Thymidine Kinase Gene

1996 • 88 citations

p53 gene therapy in a rat model of hepatocellular carcinoma: intra-arterial delivery of a recombinant adenovirus.

1998 • 88 citations

In vivo adenovirus-mediated p53 tumor suppressor gene therapy for colorectal cancer.

1996 • 86 citations

Transcriptional regulation of α-fetoprotein expression by dexamethasone in human hepatoma cells

1989 • 82 citations

Concomitant expression ofE. colicytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine

1998 • 76 citations

Tissue-specific growth suppression and chemosensitivity promotion in human hepatocellular carcinoma cells by retroviral-mediated transfer of the wild-type p53 gene

1996 • 73 citations

Hepatic colorectal metastasis: current status of surgical therapy.

1998 • 72 citations

Mutation of p53 gene in hepatocellular carcinoma in Taiwan.

1992 • 72 citations

Hepatocellular carcinoma in primary haemochromatosis in the absence of cirrhosis.

1988 • 69 citations

Surgical management of hepatocellular carcinoma: resection or transplantation?

1998 • 60 citations

Transactivation of cellular gene expression by hepatitis B viral proteins: a possible molecular mechanism of hepatocarcinogenesis.

1995 • 59 citations

Hepatitis C virus genotypes and development of hepatocellular carcinoma

1995 • 58 citations

Sex hormonal preparations and the liver

1998 • 54 citations

Treatment of Metastatic Cancer to the Liver

1994 • 52 citations

Bystander effect caused by cytosine deaminase gene and 5-fluorocytosine in vitro is substantially mediated by generated 5-fluorouracil.

1998 • 50 citations

Tissue-Specific Expression of an Anti-ras Ribozyme Inhibits Proliferation of Human Malignant Melanoma Cells

1996 • 50 citations

Preliminary report: the short-term effects of direct p53 DNA injection in primary hepatocellular carcinomas.

1996 • 47 citations

Different mutations of the p53 gene in nodule-in-nodule hepatocellular carcinoma as a evidence for multistage progression

1994 • 47 citations

Pathobiologic effects of hepatitis C.

1995 • 44 citations

Inhalation toxicity of vinyl chloride and Vinylidene chloride

1977 • 43 citations

Ganciclovir-induced ablation non-proliferating thyrocytes expressing herpesvirus thymidine kinase occurs by p53-independent apoptosis.

1996 • 40 citations

Sex steroid metabolism and receptor status in hepatic hyperplasia and cancer in rats

1996 • 37 citations

Combined Transarterial Targeting Locoregional Immunotherapy-Chemotherapy for Patients with Unresectable Hepatocellular Carcinoma: A New Alternative for an Old Problem

1995 • 36 citations

Standard postoperative monitoring of patients after primary resection of colon and rectum cancer

1993 • 34 citations

Telomerase activity in hepatocellular carcinoma and adjacent liver tissues

1998 • 33 citations

p53 as a growth suppressor gene in HBV-related hepatocellular carcinoma cells.

1993 • 32 citations

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins

1993 • 30 citations

Wild-type p53 induces apoptosis in Hep3B through up-regulation of bax expression.

1997 • 30 citations

An intercalation inhibitor altering the target selectivity of DNA damaging agents: Synthesis of site-specific aflatoxin B ₁ adducts in a p53 mutational hotspot

1997 • 29 citations

Nonsurgical management of recurrent colorectal cancer

1993 • 27 citations

Simultaneous chronic lymphocytic leukemia and chronic myelogenous leukemia. Evidence of a separate stem cell origin

1993 • 26 citations

Increased risk of death in thorotrast-exposed patients during the late follow-up period.

1987 • 25 citations

Ha-ras mutations inN-nitrosomorpholine-induced lesions and inhibition of hepatocarcinogenesis by antisense sequences in rat liver

1997 • 22 citations

Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA-in vitro and in vivo studies

1997 • 22 citations

[Echo-guided radiofrequency percutaneous ablation of hepatocellular carcinoma in cirrhosis using a cooled needle].

1998 • 17 citations

Biological interactions of N-nitroso compounds: A review

1977 • 17 citations

New Trends in the Surgical Treatment of Colorectal Cancer Liver Metastases

1998 • 17 citations

Retrovirus-mediated gene therapy for human hepatocellular carcinoma transplanted in athymic mice.

1998 • 15 citations

Oncogenes and proto-oncogenes

1986 • 14 citations

Are There Indications for Intraarterial Hepatic Chemotherapy or Isolated Liver Perfusion? The Case of Liver Metastases from Colorectal Cancer

1998 • 12 citations

Genetic Hemochromatosis: Pathogenesis, Diagnosis, and Therapy

1996 • 10 citations

Bile formation: Transport and cholestasis

1995 • 9 citations

[Hepatocellular carcinoma: npn-surgical treatment].

1998 • 2 citations

[Hepatocellular carcinoma: surgical treatment].

1998 • 1 citations

Deleted Work

1955 • 0 citations