Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies.

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Proposals for the classification of the myelodysplastic syndromes

1982 • 3,616 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

1993 • 1,306 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis

1996 • 294 citations

p53 in hematologic malignancies

1994 • 269 citations

Human p53 gene localized to short arm of chromosome 17

1986 • 222 citations

Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages

1994 • 179 citations

Separation of synthetic phosphorothioate oligodeoxynucleotides from their oxygenated (phosphodiester) defect species by strong-anion-exchange high-performance liquid chromatography

1992 • 73 citations

Expression of the p53 oncogene in acute myeloblastic leukemia.

1986 • 55 citations

Selective Cytotoxicity to Human Leukemic Myeloblasts Produced by Oligodeoxyribonucleotide Phosphorothioates Complementary to p53 Nucleotide Sequences

1994 • 48 citations

A denaturing gradient gel electrophoresis assay for sensitive detection of p53 mutations

1993 • 42 citations

OMA-AML-1: a leukemic myeloid cell line with CD34+ progenitor and CD15+ spontaneously differentiating cell compartments

1992 • 9 citations

Antisense oligonucleotide OL (1) p53 for in vitro purging of autologous bone marrow in acute myelogenous leukemia.

1994 • 6 citations