p53-dependent cell death/apoptosis is required for a productive adenovirus infection

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

Mutations and altered expression of p16INK4 in human cancer.

1994 • 547 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

1987 • 394 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

1992 • 344 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor

1996 • 315 citations

The Adenovirus E1B-55K Transforming Polypeptide Modulates Transport or Cytoplasmic Stabilization of Viral and Host Cell mRNAs

1986 • 301 citations

Comprehensive Virology

1975 • 254 citations

Virology : a practical approach

1985 • 253 citations

Alterations in p53 and p16^INK4 Expression and Telomere Length during Spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts

1995 • 248 citations

Mutation and altered expression of p16^ in human cancer

1994 • 234 citations

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1994 • 231 citations

Virology: A Practical Approach

1986 • 194 citations

The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs.

1986 • 143 citations

Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line.

1989 • 94 citations

Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.

1993 • 91 citations

Enhanced Expression of p53 in Human Cella Infected with Mutant Adenoviruses

1994 • 91 citations

Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis

1996 • 88 citations

Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells.

1995 • 75 citations

Tumor-suppressive activity of the growth arrest-specific gene GAS1 in human tumor cell lines

1998 • 51 citations

Evidence that wild‐type TP53, and not genes on either chromosome 1 or 11, controls the tumorigenic phenotype of the human fibrosarcoma HT1080

1994 • 35 citations

Functional interaction of wild-type and mutant p53 transfected into human tumor cell lines carrying activated ras genes.

1993 • 33 citations

p53/E1b58kDa Complex Regulates Adenovirus Replication

1997 • 32 citations

Adenovirus E1b-58 kD antigen binds to p53 during infection of rodent cells: evidence for an N-terminal binding site on p53.

1991 • 27 citations

Tumour-suppressive activity of the growth arrest-specific gene, GAS1 / by Andreas Avdokiou.

1997 • 1 citations