Developments in liposomal drug delivery systems

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Diffusion of univalent ions across the lamellae of swollen phospholipids

1965 • 4,347 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Long-circulating and target-specific nanoparticles: theory to practice.

2001 • 3,291 citations

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

1998 • 2,040 citations

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

1990 • 1,962 citations

Lipid polymorphism and the functional roles of lipids in biological membranes

1979 • 1,817 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

1991 • 1,591 citations

Biochemistry of Lipids, Lipoproteins and Membranes

2021 • 1,420 citations

Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid

1995 • 1,406 citations

Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo

1991 • 1,370 citations

Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.

1994 • 1,355 citations

An Inverted Hexagonal Phase of Cationic Liposome-DNA Complexes Related to DNA Release and Delivery

1998 • 1,272 citations

Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors.

1999 • 1,231 citations

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

1988 • 1,103 citations

Mechanism of DNA Release from Cationic Liposome/DNA Complexes Used in Cell Transfection^,

1996 • 1,103 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

The conformation of membranes

1991 • 950 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases

1993 • 883 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Physical properties of the fluid lipid-bilayer component of cell membranes: a perspective

1991 • 849 citations

A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.

2000 • 740 citations

Improved DNA: liposome complexes for increased systemic delivery and gene expression

1997 • 738 citations

Large unilamellar liposomes with low uptake into the reticuloendothelial system

1987 • 718 citations

Liposomes for the sustained drug release in vivo

1990 • 685 citations

Liposomes as immunological adjuvants

1974 • 659 citations

Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.

2000 • 622 citations

Engineering liposomes for drug delivery: progress and problems

1995 • 612 citations

Lipid composition and permeability of liposomes

1968 • 605 citations

Fate and behavior of liposomes in vivo: a review of controlling factors.

1987 • 594 citations

Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro

1980 • 585 citations

Virus treatment questioned after gene therapy death

1999 • 578 citations

Pharmacokinetics of stealth versus conventional liposomes: effect of dose

1991 • 566 citations

On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

2001 • 539 citations

Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: Studies with poly(ethylene glycol)-coated vesicles

1991 • 505 citations

Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.

2000 • 497 citations

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

1997 • 485 citations

Current status of pH-sensitive liposomes in drug delivery

2000 • 467 citations

Targeting Folate Receptor with Folate Linked to Extremities of Poly(ethylene glycol)-Grafted Liposomes: In Vitro Studies

1999 • 461 citations

The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake.

1995 • 448 citations

Medical Applications of Liposomes

1998 • 417 citations

The polymorphic phase behaviour of phosphatidylethanolamines of natural and synthetic origin. A 31P NMR study

1978 • 416 citations

Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery

1997 • 403 citations

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures

2001 • 402 citations

Endocytosis of liposomes and intracellular fate of encapsulated molecules: Encounter with a low pH compartment after internalization in coated vesicles

1983 • 394 citations

Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo

1998 • 372 citations

Doxorubicin Encapsulated in Liposomes Containing Surface‐Bound Polyethylene Glycol: Pharmacokinetics, Tumor Localization, and Safety in Patients with AIDS‐Related Kaposi's Sarcoma

1996 • 370 citations

Phosphatodylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications

1992 • 365 citations

Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes

1996 • 352 citations

Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection

1999 • 349 citations

Role of cholesterol in membranes effects on phospholipid-protein interactions, membrane permeability and enzymatic activity

1973 • 337 citations

Gene therapy: the first decade

2000 • 332 citations

Fighting Cancer by Attacking its Blood Supply

1996 • 331 citations

Liposomes for Gene Delivery

2004 • 326 citations

Attachment of antibodies to sterically stabilized liposomes: evaluation, comparison and optimization of coupling procedures

1995 • 312 citations

Structure and Function of Lipid-DNA Complexes for Gene Delivery

2000 • 311 citations

Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice.

1992 • 303 citations

Serum opsonins and liposomes: their interaction and opsonophagocytosis.

1992 • 297 citations

Stabilized plasmid-lipid particles: construction and characterization

1999 • 296 citations

Insertion of poly(ethylene glycol) derivatized phospholipid into pre‐formed liposomes results in prolonged in vivo circulation time

1996 • 294 citations

Molecular structure and function

1991 • 291 citations

Homing of liposomes to target cells

1975 • 291 citations

Pharmacokinetics of long-circulating liposomes

1995 • 288 citations

A new strategy for attachment of antibodies to sterically stabilized liposomes resulting in efficient targeting to cancer cells

1995 • 286 citations

Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times

1993 • 284 citations

Complexes between cationic liposomes and DNA visualized by cryo-TEM

1995 • 283 citations

Membrane bending energy concept of vesicle‐ and cell‐shapes and shape‐transitions

1994 • 271 citations

Thermosensitive liposomes: Extravasation and release of contents in tumor microvascular networks

1996 • 268 citations

The role of surface charge and hydrophilic groups on liposome clearance in vivo

1992 • 261 citations

Gelation of liposome interior A novel method for drug encapsulation

1992 • 260 citations

Roles of lipid polymorphism in intracellular delivery

2001 • 254 citations

Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration

1997 • 249 citations

Doxorubicin physical state in solution and inside liposomes loaded via a pH gradient

1998 • 248 citations

Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins

1978 • 248 citations

The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey

1990 • 246 citations

Gene therapy for cancer

1994 • 244 citations

Recognition of liposomes by cells: In vitro binding and endocytosis mediated by specific lipid headgroups and surface charge density

1992 • 239 citations

Sphingomyelin-cholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models

1995 • 236 citations

The Inhibitory Role of CpG Immunostimulatory Motifs in Cationic Lipid Vector-Mediated Transgene Expression in Vivo

1999 • 234 citations

Physicochemical Characterization and Purification of Cationic Lipoplexes

1999 • 227 citations

In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniques with those made by a new post-insertion approach

2001 • 217 citations

Reduced Inflammatory Response to Plasmid DNA Vectors by Elimination and Inhibition of Immunostimulatory CpG Motifs

2000 • 215 citations

Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes

2001 • 215 citations

A Compendium of Vaccine Adjuvants and Excipients

1995 • 214 citations

Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles

1997 • 210 citations

Transmembrane gradient driven phase transitions within vesicles: lessons for drug delivery

1995 • 206 citations

Lipid-DNA Complex Formation: Reorganization and Rupture of Lipid Vesicles in the Presence of DNA As Observed by Cryoelectron Microscopy

1999 • 204 citations

Poly(ethylene glycol)−Lipid Conjugates Regulate the Calcium-Induced Fusion of Liposomes Composed of Phosphatidylethanolamine and Phosphatidylserine

1996 • 204 citations

Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface‐grafted poly(ethylene glycol)

1996 • 203 citations

Immunogenicity and pharmacokinetic attributes of poly(ethylene glycol)-grafted immunoliposomes

1997 • 199 citations

Liposomes and hyperthermia in mice: increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes.

1994 • 182 citations

Immune effects and mechanisms of action of CpG motifs

2000 • 179 citations

ISCOMs: an adjuvant with multiple functions

1998 • 178 citations

Physical properties and functional roles of lipids in membranes

1996 • 169 citations

Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients

1993 • 168 citations

Immunoliposomes bearing polyethyleneglycol‐coupled Fab′ fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo

1997 • 168 citations

Immunoliposomes for the targeted delivery of antitumor drugs

1999 • 162 citations

Tunable pH-Sensitive Liposomes Composed of Mixtures of Cationic and Anionic Lipids

2000 • 162 citations

Targeting tumor vasculature with homing peptides from phage display

2000 • 154 citations

Kinetics of phosphatidylcholine and lysophosphatidylcholine exchange between unilamellar vesicles

1984 • 146 citations

Diplasmenylcholine−Folate Liposomes: An Efficient Vehicle for Intracellular Drug Delivery

1998 • 145 citations

Stabilized plasmid-lipid particles for systemic gene therapy

2000 • 144 citations

Poly(ethylene glycol)-Modification of the Phospholipid Vesicles by Using the Spontaneous Incorporation of Poly(ethylene glycol)-Lipid into the Vesicles

2000 • 141 citations

Initial clinical (phase I) trial of TLC D-99 (doxorubicin encapsulated in liposomes).

1993 • 137 citations

pH-Sensitive Liposomes

1993 • 130 citations

Structure and Interfacial Aspects of Self-Assembled Cationic Lipid−DNA Gene Carrier Complexes

1998 • 130 citations

Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors.

1994 • 125 citations

Anti-HER2 immunoliposomes for targeted therapy of human tumors

1997 • 122 citations

Rapid, High Level Protein Production Using DNA-based Semliki Forest Virus Vectors

1998 • 121 citations

Functions for DNA Methylation in Vertebrates

1993 • 120 citations

Anomalous solubility behavior of the antibiotic ciprofloxacin encapsulated in liposomes: a 1H-NMR study

1998 • 119 citations

Angiogenesis and cancer metastasis.

2000 • 118 citations

Surface Charge Markedly Attenuates the Nonlamellar Phase-Forming Propensities of Lipid Bilayer Membranes: Calorimetric and 31P-Nuclear Magnetic Resonance Studies of Mixtures of Cationic, Anionic, and Zwitterionic Lipids

2000 • 117 citations

Immune responses to ISCOM® formulations in animal and primate models

2001 • 115 citations

The design and development of DaunoXome® for solid tumor targeting in vivo

1997 • 114 citations

Ultrastructural characterization of cationic liposome-DNA complexes showing enhanced stability in serum and high transfection activity in vivo

1998 • 113 citations

Chemotherapy targeted to tumor vasculature

1998 • 108 citations

In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity

2000 • 107 citations

The use of phage display for the development of tumour targeting agents

2000 • 107 citations

Liposomal gene delivery: A complex package

1997 • 105 citations

ENERGETICS OF MEMBRANE DEFORMATION AND ADHESION IN CELL AND VESICLE AGGREGATIONa

1983 • 105 citations

Interbilayer transfer of phospholipid-anchored macromolecules via monomer diffusion

1993 • 105 citations

Lipid polymorphism and membrane properties

1997 • 104 citations

Stabilization of bilayer structure for unsaturated phosphatidylethanolamines by detergents

1982 • 102 citations

Recombinant viruses as a tool for therapeutic vaccination against human cancers

2000 • 99 citations

Delivery of lipids and liposomal proteins to the cytoplasm and Golgi of antigen-presenting cells

2000 • 98 citations

Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties

1999 • 96 citations

Factors influencing uptake and retention of amino-containing drugs in large unilamellar vesicles exhibiting transmembrane pH gradients

1999 • 95 citations

Cytoplasmic expression of a reporter gene by co-delivery of T7 RNA polymerase and T7 promoter sequence with cationic liposomes

1993 • 94 citations

Loading of doxorubicin into liposomes by forming Mn2+-drug complexes

1998 • 93 citations

Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice.

2000 • 92 citations

Lipid-based systems for the intracellular delivery of genetic drugs

1999 • 90 citations

Monoclonal antibody drug conjugates in the treatment of cancer

1999 • 88 citations

Spontaneous interbilayer transfer of phospholipids: Dependence of acyl chain composition

1993 • 87 citations

Poly(ethylene glycol)−Lipid Conjugates Promote Bilayer Formation in Mixtures of Non-Bilayer-Forming Lipids

1996 • 85 citations

Photoinitiated destabilization of sterically stabilized liposomes

2001 • 84 citations

Poly(ethylene glycol)-Grafted Liposomes with Oligopeptide or Oligosaccharide Ligands Appended to the Termini of the Polymer Chains

1997 • 83 citations

Mechanisms and therapeutic applications of immune stimulatory CpG DNA

1999 • 82 citations

Cancer vaccines

2001 • 81 citations

Chloroaluminum phthalocyanine tetrasulfonate delivered via acid-labile diplasmenylcholine-folate liposomes: Intracellular localization and synergistic phototoxicity

2001 • 75 citations

Ionophore-mediated uptake of ciprofloxacin and vincristine into large unilamellar vesicles exhibiting transmembrane ion gradients

1998 • 75 citations

Technetium-labelled liposome imaging for deep-seated infection

1985 • 73 citations

Targeting efficiency of PEG-immunoliposome-conjugated antibodies at PEG terminals

1997 • 72 citations

Liposomal Vaccines: Clinical Status and Immunological Presentation for Humoral and Cellular Immunity

1995 • 68 citations

Peptide attachment to extremities of liposomal surface grafted PEG chains: preparation of the long-circulating form of laminin pentapeptide, YIGSR

1995 • 67 citations

Adjuvant properties of non-phospholipid liposomes (Novasomes®) in experimental animals for human vaccine antigens

1996 • 65 citations

Morphological responses to calcium-induced interaction of phosphatidylserine-containing vesicles

1986 • 64 citations

Dynamic morphology of calcium-induced interactions between phosphatidylserine vesicles

1985 • 63 citations

Adjuvant activity of immunopotentiating reconstituted influenza virosomes (IRIVs)

1999 • 62 citations

Uptake and processing of liposomal phospholipids by Kupffer cells in vitro

1985 • 62 citations

Liposome targeting to tumors using vitamin and growth factor receptors

2000 • 61 citations

Intratumor distribution of doxorubicin following i.v. administration of drug encapsulated in egg phosphatidylcholine/cholesterol liposomes

1997 • 58 citations

Liposomes in Biomedical Applications

1995 • 56 citations

Angiogenic zip code

1999 • 54 citations

DNA vaccines--challenges in delivery.

2000 • 54 citations

Therapy of Cancer Metastasis by Tumoricidal Activation of Tissue Macrophages Using Liposome-Encapsulated Immunomodulators

1998 • 53 citations

A novel T7 RNA polymerase autogene for efficient cytoplasmic expression of target genes

1999 • 53 citations

Immunogenicity of immunoliposomes: reactivity against species-specific IgG and liposomal phospholipids

1995 • 52 citations

Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

2001 • 50 citations

Nonlamellar phases formed by membrane lipids

1992 • 44 citations

Functional Immunoliposomes Harboring a Biosynthetically Lipid-Tagged Single-Chain Antibody

1994 • 44 citations

In Vivo Targeting by Liposomes.

2000 • 44 citations

Liposome-Mediated Cytoplasmic Delivery of Proteins: An Effective Means of Accessing the MHC Class I-Restricted Antigen Presentation Pathway

1994 • 41 citations

Encapsulation of Plasmid DNA in Stabilized Plasmid – Lipid Particles Composed of Different Cationic Lipid Concentration for Optimal Transfection Activity

2000 • 40 citations

Hyperthermia enhances tumor uptake and antitumor efficacy of thermostable liposomal daunorubicin in a rat solid tumor.

1996 • 37 citations

Diversity of lipid-based polyene formulations and their behavior in biological systems

1997 • 32 citations

Cationic poly(ethyleneglycol) lipids incorporated into pre-formed vesicles enhance binding and uptake to BHK cells

2001 • 31 citations

Biosynthetically lipid‐modified human scFv fragments from phage display libraries as targeting molecules for immunoliposomes

1996 • 31 citations

Complexation of Internalized Doxorubicin into Fiber Bundles Affects its Release Rate from Liposomes

2000 • 31 citations

Cytokine-Containing Liposomes as Adjuvants for HIV Subunit Vaccines

1995 • 28 citations

Immunogenicity of immunoliposomes

1991 • 27 citations

Phase I Trial of ImmTher, a New Liposome-Incorporated Lipophilic Disaccharide Tripeptide

1991 • 26 citations

ImmTher, a lipophilic disaccharide derivative of muramyl dipeptide, up-regulates specific monocyte cytokine genes and activates monocyte-mediated tumoricidal activity

1999 • 24 citations

Physical biochemistry of a liposomal amphotericin B mixture used for patient treatment

1989 • 22 citations

Designing therapeutically optimized liposomal anticancer delivery systems: Lessons from conventional liposomes

1998 • 21 citations

The Perplexing Delivery Mechanism of Lipoplexes

1999 • 21 citations

Induction of Nitric Oxide Production and Tumoricidal Properties in Murine Macrophages by a New Synthetic Lipopeptide JBT3002 Encapsulated in Liposomes

1998 • 20 citations

Interaction of polyene antibiotics with membrane lipids: physicochemical studies of the molecular basis of selectivity.

1986 • 18 citations

The interaction of apolipoprotein A-I with small unilamellar vesicles of L-alpha-dipalmitoylphosphatidylcholine.

1985 • 18 citations

Biophysical validation of Epaxal Berna, a hepatitis A vaccine adjuvanted with immunopotentiating reconstituted influenza virosomes (IRIV).

2000 • 15 citations

Chapter 12 Drug Delivery Applications

1997 • 13 citations

Progress in Gene Delivery Research and Development

1999 • 12 citations

Opportunities in targeted drug delivery to Kupffer cells: delivery of immunomodulators to Kupffer cells-activation of tumoricidal properties

1995 • 11 citations

Targeting Tumor Vasculature Using VEGF-Toxin Conjugates

2003 • 11 citations

Self-amplifying vectors for gene delivery

1997 • 10 citations

Technology evaluation: gene therapy (IL-2), Valentis Inc.

2000 • 10 citations

Cytokine-Containing Liposomes as Adjuvants for Subunit Vaccines

1995 • 9 citations

Targeting of drugs : strategies for gene constructs and delivery

2000 • 9 citations

Cationic lipid-mediated gene transfer to the growing murine and human airway

2000 • 8 citations

Deleted Work

1955 • 0 citations