Opportunities in targeted drug delivery to Kupffer cells: delivery of immunomodulators to Kupffer cells-activation of tumoricidal properties

Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives

1974 • 1,038 citations

Cells of the hepatic sinusoid

1989 • 589 citations

Cells of the hepatic sinusoid

1998 • 557 citations

Adjuvant Therapy of Colorectal Cancer

1988 • 376 citations

Liposomes as carriers of antigens and adjuvants

1991 • 350 citations

Specific endotoxic lipopolysaccharide-binding proteins on murine splenocytes. I. Detection of lipopolysaccharide-binding sites on splenocytes and splenocyte subpopulations.

1988 • 173 citations

Phase II study of liposomal muramyl tripeptide in osteosarcoma: the cytokine cascade and monocyte activation following administration.

1992 • 151 citations

Biological Response Modifiers

1989 • 125 citations

Specific endotoxic lipopolysaccharide-binding proteins on murine splenocytes. II. Membrane localization and binding characteristics.

1988 • 111 citations

Macrophages and cancer

1990 • 109 citations

Phase I trial of liposomal muramyl tripeptide phosphatidylethanolamine in cancer patients.

1989 • 108 citations

Enhanced tumour growth in the rat liver after selective elimination of Kupffer cells

1993 • 97 citations

Importance of Local Proliferation in the Expanding Kupffer Cell Population of Rat Liver After Zymosan Stimulation and Partial Hepatectomy

1984 • 94 citations

In vitro activation of rat liver macrophages to tumoricidal activity by free or liposome-encapsulated muramyl dipeptide.

1986 • 82 citations

Modulation of the biological activity of bacterial endotoxin by incorporation into liposomes.

1987 • 79 citations

Activation of tumoricidal properties in monocytes from cancer patients following intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine.

1989 • 72 citations

Adjuvant therapy of colorectal cancer. Why we still don't know

1988 • 68 citations

Identification of lipopolysaccharide-binding proteins in 70Z/3 cells by photoaffinity cross-linking.

1990 • 68 citations

Natural cytotoxicity of rat hepatic natural killer cells and macrophages against a syngeneic colon adenocarcinoma

1988 • 62 citations

Influence of chemotherapy administration on monocyte activation by liposomal muramyl tripeptide phosphatidylethanolamine in children with osteosarcoma.

1991 • 61 citations

Kupffer cells and liver metastasis

1989 • 58 citations

The activation of tumoricidal properties in human blood monocytes by muramyl dipeptide requires specific intracellular interaction.

1986 • 48 citations

Natural cytotoxicity of isolated rat liver cells.

1982 • 47 citations

Biological activity of liposome-encapsulated murine interferon gamma is mediated by a cell membrane receptor.

1985 • 45 citations

Liposomes and biotherapeutics

1991 • 43 citations

The role of Kupffer cells in the differentiation process of hepatic natural killer cells

1995 • 42 citations

Liver macrophages (Kupffer cells) as cytotoxic effector cells in extracellular and intracellular cytotoxicity

1985 • 41 citations

Phase I and immunomodulatory study of a muramyl peptide, muramyl tripeptide phosphatidylethanolamine.

1990 • 40 citations

Inhibition of experimental liver tumor growth in mice by liposomes containing a lipophilic muramyl dipeptide derivative.

1989 • 39 citations

Activation of murine kupffer cell tumoricidal activity by liposomes containing lipophilic muramyl dipeptide

1988 • 37 citations

Biological Response Modifiers

1985 • 37 citations

Incorporation of LPS in Liposomes Diminishes Its Ability to Induce Tumoricidal Activity and Tumor Necrosis Factor Secretion in Murine Macrophages

1988 • 37 citations

Human Kupffer cells are cytotoxic against human colon adenocarcinoma

1990 • 34 citations

Murine Kupffer cells and hepatic natural killer cells regulate tumor growth in a quantitative model of colorectal liver metastases

1992 • 34 citations

Liposomes containing lipid A as a potent non-toxic adjuvant

1992 • 34 citations

Stimulation of macrophage protease secretion via liposomal delivery of muramyl dipeptide derivatives to intracellular sites.

1984 • 32 citations

Inhibition of murine hepatic tumor growth by liposomes containing a lipophilic muramyl dipeptide

1989 • 31 citations

The activation of tumoricidal properties in macrophages of endotoxin responder and nonresponder mice by liposome-encapsulated immunomodulators.

1983 • 31 citations

Systemic macrophage activation with liposome-entrapped immunomodulators for therapy of cancer metastasis

1992 • 30 citations

Efficient activation of human blood monocytes to a tumoricidal state by liposomes containing human recombinant gamma interferon

1985 • 30 citations

Therapy of Murine Liver Metastases by Administration of MDP Encapsulated in Liposomes

1990 • 26 citations

Phase I Trial of ImmTher, a New Liposome-Incorporated Lipophilic Disaccharide Tripeptide

1991 • 26 citations

Heterogeneity in secretory responses of rat liver macrophages of different size

1995 • 25 citations

Induction of tumoricidal activity in isolated rat liver macrophages by liposomes containing recombinant rat gamma-interferon supplemented with lipopolysaccharide or muramyldipeptide.

1987 • 22 citations

Endocytic and Tumoricidal Heterogeneity of Rat Liver Macrophage Populations

1989 • 21 citations

Differential effects of liposome-incorporation on liver macrophage activating potencies of rough lipopolysaccharide, lipid A, and muramyl dipeptide. Differences in susceptibility to lysosomal enzymes.

1989 • 18 citations

Mouse Interferon-γ in Liposomes: Pharmacokinetics, Organ-Distribution, and Activation of Spleen and Liver MacrophagesIn Vivo

1989 • 17 citations

Functional Characteristics of the Rat Liver Macrophage Population After a Single Intravenous Injection of Liposome-Encapsulated Muramyl Peptides

1993 • 17 citations

Muramyl Peptides as Immunopharmacological Response Modifiers

1985 • 17 citations

Maintenance of Tumoricidal Activity and Susceptibility to Reactivation of Subpopulations of Rat Liver Macrophages

1991 • 16 citations

Liposomal muramyl dipeptide therapy of experimental M5076 liver metastases in mice

1991 • 15 citations

Anti-metastatic activity in vivo of MDP-l-alanyl-cholesterol (MTP-Chol) entrapped in nanocapsules

1991 • 14 citations

Secretion Pattern of the Rat Liver Macrophage Population Following Activation with Liposomal Muramyl Dipeptide In Vivo and In Vitro

1994 • 12 citations

Stimulation of Kupffer cell tumoricidal activity by liposomal muramyl dipeptides

1992 • 12 citations

The effect of liver macrophages on in vitro cytolytic activity of 5FU and FUDR on colon carcinoma cells: Evidence of macrophage activation

1992 • 11 citations

Chemoimmunotherapy of Murine Liver Metastases with 5-Fluorouracil in Combination with Liposome-Encapsulated Muramyl Dipeptide

1993 • 8 citations

Intracellular activation of tumoricidal properties in mouse macrophages and human monocytes by recombinant mouse or human gamma interferon encapsulated in liposomes

1986 • 8 citations

Activation of rat Kupffer cells to tumoricidal cells by the immunomodulator muramyl tripeptide-phosphatidylethanolamine incorporated into the novel drug carrier lactosylated low density lipoprotein.

1994 • 4 citations

Repeated Intravenous Administration of Liposome-Encapsulated Muramyl Tripeptide-Phosphatidyl-Ethanolamine Diminishes Cytotoxic Potential of Subpopulations of Rat Liver Macrophages

1995 • 3 citations

Deleted Work

1955 • 0 citations