Designing therapeutically optimized liposomal anticancer delivery systems: Lessons from conventional liposomes

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

1996 • 1,206 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis.

1994 • 682 citations

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

1988 • 680 citations

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.

1990 • 567 citations

Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes

1994 • 532 citations

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

1992 • 501 citations

Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity

1994 • 463 citations

Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

1992 • 454 citations

Long-circulating (sterically stabilized) liposomes for targeted drug delivery

1994 • 449 citations

Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes.

1992 • 422 citations

Combination versus single agent chemotherapy: A review of the basis for selection of drug treatment of cancer

1975 • 398 citations

Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue.

1993 • 368 citations

Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice.

1989 • 351 citations

Liposomes: From Biophysics to Therapeutics

1989 • 342 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor: An Important Mediator of Angiogenesis in Malignancy and Inflammation

1995 • 337 citations

Doxorubicin in sterically stabilized liposomes

1996 • 306 citations

Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma.

1992 • 275 citations

Adriamycin (NSC 123127) cardiomyopathy. An overview with determination of risk factors

1975 • 274 citations

Phase I and preliminary phase II evaluation of adriamycin (NSC 123127).

1970 • 273 citations

Influence of Cholesterol on the Association of Plasma Proteins with Liposomes

1996 • 263 citations

Liposomes as in vivo carriers of adriamycin: reduced cardiac uptake and preserved antitumor activity in mice.

1982 • 260 citations

Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection

1985 • 252 citations

Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins

1978 • 248 citations

Consequences of angiogenesis for tumor progression, metastasis and cancer therapy

1995 • 243 citations

Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes

1992 • 241 citations

Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice.

1993 • 239 citations

Sphingomyelin-cholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models

1995 • 236 citations

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.

1996 • 235 citations

Liposome disposition in vivo

1981 • 227 citations

Poly(ethylene glycol)−Lipid Conjugates Regulate the Calcium-Induced Fusion of Liposomes Composed of Phosphatidylethanolamine and Phosphatidylserine

1996 • 204 citations

Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface‐grafted poly(ethylene glycol)

1996 • 203 citations

Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.

1992 • 191 citations

Adriamycin Cardiotoxicity in Man

1974 • 188 citations

Interactions of liposomes with serum proteins

1986 • 183 citations

Liposomes and hyperthermia in mice: increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes.

1994 • 182 citations

Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.

1995 • 182 citations

Characterization, toxicity and therapeutic efficacy of adrïamycin encapsulated in liposomes

1982 • 176 citations

Drug Resistance in Oncology

1994 • 173 citations

β2-Glycoprotein I Is a Major Protein Associated with Very Rapidly Cleared Liposomes in Vivo, Suggesting a Significant Role in the Immune Clearance of “Non-self” Particles

1995 • 169 citations

New Synthetic Amphiphilic Polymers for Steric Protection of Liposomes in Vivo

1995 • 165 citations

Liposomal doxorubicin‐induced toxicity: Depletion and impairment of phagocytic activity of liver macrophages

1995 • 150 citations

pH-sensitive immunoliposomes as an efficient and target-specific carrier for antitumor drugs.

1986 • 145 citations

Clinical applications of hematopoietic growth factors.

1995 • 143 citations

Initial clinical (phase I) trial of TLC D-99 (doxorubicin encapsulated in liposomes).

1993 • 137 citations

Factors influencing the retention and chemical stability of poly(ethylene glycol)-lipid conjugates incorporated into large unilamellar vesicles

1994 • 131 citations

Extravasation and transcytosis of liposomes in Kaposi's sarcoma-like dermal lesions of transgenic mice bearing the HIV tat gene.

1993 • 127 citations

The effects of cancer chemotherapeutic agents on normal hematopoietic precursor cells: a review.

1976 • 126 citations

Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: the lack of beneficial effects by coating liposomes with poly(ethylene glycol).

1997 • 124 citations

Cholesterol content of small unilamellar liposomes controls phospholipid loss to high density lipoproteins in the presence of serum

1980 • 123 citations

Liposomes with entrapped doxorubicin exhibit extended blood residence times

1990 • 120 citations

Reduced cardiotoxicity and nephrotoxicity with preservation of antitumor activity of doxorubicin entrapped in stable liposomes in the LOU/M Wsl rat.

1984 • 117 citations

Enhanced delivery and antitumor activity of doxorubicin using long-circulating thermosensitive liposomes containing amphipathic polyethylene glycol in combination with local hyperthermia.

1994 • 112 citations

Influence of dose on liposome clearance: critical role of blood proteins

1996 • 111 citations

Sterically Stabilized Liposomes: Physical and Biological Properties

1994 • 110 citations

Arrest of human lung tumor xenograft growth in severe combined immunodeficient mice using doxorubicin encapsulated in sterically stabilized liposomes.

1993 • 104 citations

Pharmacological, toxicological, and therapeutic evaluation in mice of doxorubicin entrapped in cardiolipin liposomes.

1985 • 99 citations

Formation of asymmetric phospholipid membranes via spontaneous transfer of fluorescent lipid analogs between vesicle populations

1981 • 96 citations

Cytotoxic thresholds of vincristine in a murine and a human leukemia cell line in vitro.

1979 • 90 citations

Poly(ethylene glycol)−Lipid Conjugates Promote Bilayer Formation in Mixtures of Non-Bilayer-Forming Lipids

1996 • 85 citations

Identification of vesicle properties that enhance the antitumour activity of liposomal vincristine against murine L1210 leukemia

1993 • 84 citations

Influence of drug release characteristics on the therapeutic activity of liposomal mitoxantrone.

1997 • 81 citations

Pharmacokinetics and anti‐tumor activity of vincristine encapsulated in sterically stabilized liposomes

1995 • 79 citations

Dose‐dependent pharmacokinetics: Experimental observations and theoretical considerations

1994 • 73 citations

Release of doxorubicin from peritoneal macrophages exposed in vivo to doxorubicin-containing liposomes

1988 • 71 citations

Studies on the myelosuppressive activity of doxorubicin entrapped in liposomes

1990 • 71 citations

Eosinophilic vasculitis in connective tissue disease

1996 • 65 citations

Application of fusogenic liposomes containing fragment A of diphtheria toxin to cancer therapy

1996 • 61 citations

The role of tumor-associated macrophages in the delivery of liposomal doxorubicin to solid murine fibrosarcoma tumors.

1997 • 56 citations

Acquired immunodeficiency syndrome. Introduction.

1984 • 55 citations

Pharmacology of liposomal vincristine in mice bearing L1210 ascitic and B16/BL6 solid tumours

1995 • 55 citations

Phase I and pharmacokinetic trial of liposome-encapsulated doxorubicin

1993 • 49 citations

The Use of Transmembrane pH Gradient-Driven Drug Encapsulation in the Pharmacodynamic Evaluation of Liposomal Doxorubicin

1994 • 48 citations

Biodistribution of clodronate and liposomes used in the liposome mediated macrophage ‘suicide’ approach

1996 • 45 citations

Plasma clearance, biodistribution and therapeutic properties of mitoxantrone encapsulated in conventional and sterically stabilized liposomes after intravenous administration in BDF1 mice

1997 • 42 citations

Lymphoid tissues targeting of liposome-encapsulated 2/,3/-dideoxyinosine

1995 • 39 citations

Strategies for Optimizing Liposomal Doxorubicin

1990 • 35 citations

The Effect of Dose on the Distribution of Adriamycin Encapsulated in Polyethyleneglycol-Coated Liposomes

1995 • 33 citations

Evaluation of incorporation characteristics of mitoxantrone into unilamellar liposomes and analysis of their pharmacokinetic properties, acute toxicity, and antitumor efficacy

1991 • 31 citations

The presence of GM1 in liposomes with entrapped doxorubicin does not prevent RES blockade

1993 • 26 citations

Dose intensity and high dose therapy. Two different concepts

1994 • 25 citations

Cytotoxicity of anti-c-erbB-2 immunoliposomes containing doxorubicin on human cancer cells

1995 • 24 citations

Influence of plasma on the osmotic sensitivity of large unilamellar vesicles prepared by extrusion.

1994 • 24 citations

Relationship between binding affinity, retention and sensitivity of human rhabdomyosarcoma xenografts to vinca alkaloids

1987 • 17 citations

pH-sensitive liposomes composed of phosphatidylethanolamine and fatty acid.

1990 • 16 citations

Preclinical and Clinical Experience with Liposome-Encapsulated Mitoxantrone

1994 • 13 citations

Photodynamic therapy of human bladder carcinoma cells in vitro with pH-sensitive liposomes as carriers for 9-acetoxy-tetra-n-propylporphycene

1994 • 12 citations

The Challenge Of Liposome Targeting In Vivo

2018 • 8 citations

Circulation lifetimes and tumor accumulation of liposomal drug delivery systems

1995 • 2 citations