Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

1998 • 951 citations

Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

1998 • 759 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

1998 • 500 citations

X-Linked Lymphoproliferative Disease

2000 • 470 citations

Cooperative Inhibition of T-Cell Antigen Receptor Signaling by a Complex between a Kinase and a Phosphatase

1999 • 427 citations

Structures of Src-family tyrosine kinases

1997 • 377 citations

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.

1992 • 335 citations

Cutting Edge: Human 2B4, an Activating NK Cell Receptor, Recruits the Protein Tyrosine Phosphatase SHP-2 and the Adaptor Signaling Protein SAP

1999 • 308 citations

Gntb-A, a Novel Sh2d1a-Associated Surface Molecule Contributing to the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected B Cells in X-Linked Lymphoproliferative Disease

2001 • 306 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease geneSH2D1A/DSHP/SAP

2001 • 270 citations

Cutting Edge: Functional Requirement for SAP in 2B4-Mediated Activation of Human Natural Killer Cells as Revealed by the X-Linked Lymphoproliferative Syndrome

2000 • 263 citations

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

2001 • 258 citations

Crystal Structures of the XLP Protein SAP Reveal a Class of SH2 Domains with Extended, Phosphotyrosine-Independent Sequence Recognition

1999 • 244 citations

SAP controls T cell responses to virus and terminal differentiation of TH2 cells

2001 • 242 citations

X-Linked Lymphoproliferative Disease: A Progressive Immunodeficiency

2001 • 226 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo

2002 • 115 citations

Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

1999 • 109 citations

EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene.

1996 • 109 citations

CDw150 Associates with Src-Homology 2-Containing Inositol Phosphatase and Modulates CD95-Mediated Apoptosis

1999 • 102 citations

A ‘three-pronged’ binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

2002 • 86 citations

Regulation of T-Cell Antigen Receptor Signalling by Syk Tyrosine Protein Kinase

1997 • 76 citations

Regulation of SOCS-1 Expression by Translational Repression

2000 • 70 citations

A Potential SH3 Domain-binding Site in the Crk SH2 Domain

1996 • 48 citations

Synergistic Regulation of Immunoreceptor Signaling by SLP-76-Related Adaptor Clnk and Serine/Threonine Protein Kinase HPK-1

2001 • 48 citations

The SAP Family: A New Class of Adaptor-Like Molecules That Regulates Immune Cell Functions

2002 • 21 citations