Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

NKT cells: facts, functions and fallacies

2000 • 875 citations

Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells

1999 • 856 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4

1997 • 612 citations

The NOD mouse model of type 1 diabetes: As good as it gets?

1999 • 592 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

α/β–T Cell Receptor (TCR)+CD4−CD8− (NKT) Thymocytes Prevent Insulin-dependent Diabetes Mellitus in Nonobese Diabetic (NOD)/Lt Mice by the Influence of Interleukin (IL)-4 and/or IL-10

1998 • 473 citations

Overexpression of Natural Killer T Cells Protects Vα14-Jα281 Transgenic Nonobese Diabetic Mice against Diabetes

1998 • 390 citations

Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site

1999 • 360 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells

2000 • 330 citations

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice.

1996 • 290 citations

The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms.

1993 • 219 citations

Natural killer cells determine the outcome of B cell–mediated autoimmunity

2000 • 187 citations

Innate immunity and autoimmunity: from self-protection to self-destruction

2001 • 149 citations

Genetic Control of Diabetes Progression

1997 • 148 citations

Chemokines, chemokine receptors and hematopoiesis

2000 • 142 citations

A Defect in Interleukin 12–Induced Activation and Interferon γ Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-Dependent Diabetes Mellitus

1999 • 136 citations

CD1-restricted T-cell responses and microbial infection

2000 • 128 citations

Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes

2000 • 113 citations

Mechanism Underlying Counterregulation of Autoimmune Diabetes by IL-4

1997 • 100 citations

The Temporal Importance of TNFα Expression in the Development of Diabetes

2000 • 99 citations

Pancreas-Infiltrating Th1 Cells and Diabetes Develop in IL-12-Deficient Nonobese Diabetic Mice

1999 • 96 citations

Mapping and identification of autoimmunity genes

2000 • 70 citations

Dissecting the role of CD4⁺ T cells in autoimmune diabetes through the use of TCR transgenic mice

1999 • 37 citations