Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage

1980 • 1,668 citations

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2000 • 1,665 citations

Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

2002 • 1,037 citations

Recognition of a lipid antigen by CD1-restricted αβ+ T cells

1994 • 976 citations

Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, Is an Endocytic Receptor that Induces the Formation of Birbeck Granules

2000 • 934 citations

CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens

1995 • 751 citations

Immunologic Functions of Ia-Bearing Epidermal Langerhans Cells

1978 • 732 citations

DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells

2002 • 620 citations

Ia antigen expression on human epidermal Langerhans cells

1977 • 603 citations

CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen

1992 • 577 citations

Reactivity of Langerhans cells with hybridoma antibody.

1981 • 560 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Recognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyte

1989 • 521 citations

Epidermal Langerhans cells express Ia antigens

1977 • 493 citations

CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

2000 • 440 citations

Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells

1997 • 437 citations

Nonpeptide ligands for human gamma delta T cells.

1994 • 373 citations

Glycolipid Antigen Processing for Presentation by CD1d Molecules

2001 • 289 citations

The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface

1999 • 282 citations

Predominant structural features of the cell wall arabinogalactan of Mycobacterium tuberculosis as revealed through characterization of oligoglycosyl alditol fragments by gas chromatography/mass spectrometry and by 1H and 13C NMR analyses.

1990 • 267 citations

The Cell Surface Receptor DC-SIGN Discriminates betweenMycobacterium Species through Selective Recognition of the Mannose Caps on Lipoarabinomannan

2003 • 264 citations

T Cell Activation by Lipopeptide Antigens

2004 • 262 citations

Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 Å

2003 • 228 citations

CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family.

1996 • 212 citations

Separate Pathways for Antigen Presentation by CD1 Molecules

1999 • 200 citations

Intracellular pathways of CD1 antigen presentation

2003 • 192 citations

CD1-Restricted Microbial Lipid Antigen-Specific Recognition Found in the CD8+ αβ T Cell Pool

1999 • 187 citations

CD1 molecule expression on human monocytes induced by granulocyte-macrophage colony-stimulating factor.

1993 • 183 citations

Birbeck Granules Are Subdomains of Endosomal Recycling Compartment in Human Epidermal Langerhans Cells, Which Form Where Langerin Accumulates

2002 • 177 citations

Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells

2003 • 175 citations

Failure of Trafficking and Antigen Presentation by CD1 in AP-3-Deficient Cells

2002 • 174 citations

T-cell release of granulysin contributes to host defense in leprosy

2001 • 173 citations

The Tyrosine-Containing Cytoplasmic Tail of CD1b Is Essential for Its Efficient Presentation of Bacterial Lipid Antigens

1998 • 144 citations

CD1 Expression in Human Atherosclerosis

1999 • 137 citations

A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein.

1992 • 133 citations

Human epidermal Langerhans cells cointernalize by receptor-mediated endocytosis "nonclassical" major histocompatibility complex class I molecules (T6 antigens) and class II molecules (HLA-DR antigens).

1987 • 92 citations

A pathway of costimulation that prevents anergy in CD28- T cells: B7-independent costimulation of CD1-restricted T cells.

1995 • 88 citations

Epidermal Langerhans Cells Efficiently Mediate CD1a-Dependent Presentation of Microbial Lipid Antigens to T Cells

2003 • 63 citations

HIV-infected human Langerhans cells transmit infection to human lymphoid tissue ex vivo

2000 • 51 citations

The pathogenesis of the early skin lesion in leprosy

1973 • 35 citations

CD1 Presents Antigens from a Gram-Negative Bacterium,Haemophilus influenzaeType b

1998 • 33 citations

Cultured Human Langerhans Cells Process and Present Intact Protein Antigens

1992 • 29 citations

Analysis of binding of mannosides in relation to Langerin (CD207) in Langerhans cells of normal and transformed epithelia.

2002 • 15 citations