Revival of CD8+ Treg–mediated suppression

Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis

1999 • 1,212 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

2005 • 532 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Regulation of Antigen-Specific CD8 ⁺ T Cell Homeostasis by Perforin and Interferon-γ

2000 • 452 citations

CD4+ Tregs and immune control

2004 • 417 citations

Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 ^-/- Mice

1992 • 359 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

Role of CD8 ⁺ T Cells in Murine Experimental Allergic Encephalomyelitis

1992 • 351 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Analysis of regulatory CD8 T cells in Qa-1-deficient mice

2004 • 330 citations

Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T–T cell interactions

1988 • 324 citations

CD4+ Tregs and immune control

2004 • 316 citations

Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis

2004 • 305 citations

MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell Vaccination

1993 • 286 citations

Cutting Edge: CD8+CD122+ Regulatory T Cells Produce IL-10 to Suppress IFN-γ Production and Proliferation of CD8+ T Cells

2005 • 268 citations

Regulatory functions of CD8+CD28– T cells in an autoimmune disease model

2003 • 262 citations

T Cell Responses Modulated Through Interaction Between CD8αα and the Nonclassical MHC Class I Molecule, TL

2001 • 257 citations

Alloantigen specific CD8+CD28− FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity

2004 • 257 citations

Emerging Challenges in Regulatory T Cell Function and Biology

2007 • 245 citations

A Unique Subset of Self-specific Intraintestinal T Cells Maintains Gut Integrity

2002 • 227 citations

Therapeutic Induction of Regulatory, Cytotoxic CD8+ T Cells in Multiple Sclerosis

2006 • 202 citations

Precursors of Functional MHC Class I- or Class II-Restricted CD8αα+ T Cells Are Positively Selected in the Thymus by Agonist Self-Peptides

2002 • 201 citations

Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation

2004 • 198 citations

Control of Experimental Autoimmune Encephalomyelitis by T Cells Responding to Activated T Cells

1989 • 197 citations

The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease.

1993 • 197 citations

CD8⁺CD28⁻ T suppressor cells and the induction of antigen‐specific, antigen‐presenting cell‐mediated suppression of Th reactivity

2001 • 185 citations

Defects in CD8+ Regulatory T Cells in the Lamina Propria of Patients with Inflammatory Bowel Disease

2005 • 182 citations

Defective Central Tolerance Induction in NOD Mice: Genomics and Genetics

2005 • 179 citations

Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells

2007 • 178 citations

Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines

2003 • 172 citations

Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.

1978 • 172 citations

FOXP3: Not just for regulatory T cells anymore

2006 • 165 citations

Molecular mimicry mediated by MHC class Ib molecules after infection with Gram-negative pathogens

2000 • 153 citations

Mouse TCRαβ+CD8αα Intraepithelial Lymphocytes Express Genes That Down-Regulate Their Antigen Reactivity and Suppress Immune Responses

2007 • 151 citations

T cell vaccination induces T cell receptor Vβ-specific Qa-1-restricted regulatory CD8⁺T cells

1998 • 140 citations

The B7/CD28 costimulatory family in autoimmunity

2005 • 133 citations

CD8⁺T cells control the TH phenotype of MBP-reactive CD4⁺T cells in EAE mice

2001 • 124 citations

Requirement for CD8⁺Cells in T Cell Receptor Peptide-Induced Clonal Unresponsiveness

1993 • 122 citations

Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.

1995 • 116 citations

Cutting Edge: In Vitro-Generated Tolerogenic APC Induce CD8+ T Regulatory Cells That Can Suppress Ongoing Experimental Autoimmune Encephalomyelitis

2004 • 109 citations

Peripheral CD8+CD25+ T Lymphocytes from MHC Class II-Deficient Mice Exhibit Regulatory Activity

2005 • 98 citations

Selection and Expansion of CD8α/α1 T Cell Receptor α/β1 Intestinal Intraepithelial Lymphocytes in the Absence of Both Classical Major Histocompatibility Complex Class I and Nonclassical Cd1 Molecules

1999 • 97 citations

Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis

2008 • 94 citations

Homeostatic control of immunity by TCR peptide–specific Tregs

2004 • 94 citations

Regulation of Immunity by a Novel Population of Qa-1-Restricted CD8αα+TCRαβ+ T Cells

2006 • 92 citations

Apoptotic Cells Induce Tolerance by Generating Helpless CD8+ T Cells That Produce TRAIL

2007 • 87 citations

Regulatory T Cells Control Autoimmunity In Vivo by Inducing Apoptotic Depletion of Activated Pathogenic Lymphocytes

2003 • 86 citations

Induction or Protection from Experimental Autoimmune Encephalomyelitis Depends on the Cytokine Secretion Profile of TCR Peptide-Specific Regulatory CD4 T Cells

1998 • 81 citations

Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes

2004 • 76 citations

Anti-idiotypic cytotoxic T cells in rats with graft-versus-host disease

1984 • 74 citations

Thymic differentiation of TCRαβ⁺ CD8αα⁺ IELs

2007 • 73 citations

The immunoregulatory effects of Qa‐1

2006 • 72 citations

Specific control of immunity by regulatory CD8 T cells.

2005 • 72 citations

Positive Selection of a Qa-1-Restricted T Cell Receptor with Specificity for Insulin

2002 • 71 citations

Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules.

1999 • 70 citations

Development of Cd8α/α and Cd8α/β T Cells in Major Histocompatibility Complex Class I–Deficient Mice

1999 • 68 citations

Cutting Edge: TCRαβ+ CD8αα+ T Cells Are Found in Intestinal Intraepithelial Lymphocytes of Mice That Lack Classical MHC Class I Molecules

1999 • 65 citations

Specific unresponsiveness to transplantation antigens induced by auto-immunisation with syngeneic, antigen-specific T lymphoblasts

1976 • 63 citations

A Peptide from Heat Shock Protein 60 Is the Dominant Peptide Bound To Qa-1 in the Absence of the MHC Class Ia Leader Sequence Peptide Qdm

2003 • 61 citations

Non-antigen specific CD8+ T suppressor lymphocytes

2004 • 58 citations

Recombinant T cell receptor molecules can prevent and reverse experimental autoimmune encephalomyelitis: dose effects and involvement of both CD4 and CD8 T cells.

1997 • 51 citations

Cutting Edge: HLA-E Binds a Peptide Derived from the ATP-Binding Cassette Transporter Multidrug Resistance-Associated Protein 7 aSnd Inhibits NK Cell-Mediated Lysis

2005 • 48 citations

The Nonclassical MHC Class I Molecule Qa-1 Forms Unstable Peptide Complexes

2004 • 48 citations

A Novel Alloantigen-Specific CD8+PD1+ Regulatory T Cell Induced by ICOS-B7h Blockade In Vivo

2007 • 42 citations

Anti-TCR Antibody Treatment Activates a Novel Population of Nonintestinal CD8αα+TCRαβ+ Regulatory T Cells and Prevents Experimental Autoimmune Encephalomyelitis

2007 • 40 citations

Regulatory T cells: potential in organ transplantation.1

2004 • 37 citations

Induction of a type 1 regulatory CD4 T cell response following Vβ8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis

2001 • 35 citations

Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the Vβ8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4 or -10

2003 • 23 citations

Vaccination with T cell receptor peptides primes anti‐receptor cytotoxic T lymphocytes (CTL) and anergizes T cells specifically recognized by these CTL

1994 • 21 citations

The same genomic region conditions clonal deletion and clonal deviation to the CD8αα and regulatory T cell lineages in NOD versus C57BL/6 mice

2007 • 18 citations