Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25− CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Regulatory T Cells

2000 • 1,827 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

The Immunology of Mucosal Models of Inflammation

2002 • 1,323 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin

1994 • 1,131 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

2001 • 556 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Expression of the integrin α_Eβ₇identifies unique subsets of CD25⁺as well as CD25⁻regulatory T cells

2002 • 476 citations

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

1999 • 456 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

A Disquisition on Suppressor T Cells

1975 • 255 citations

CD4+ regulatory T cells in autoimmunity and allergy

2002 • 236 citations

Mouse NK1.1+ T cells: a new family of T cells

1996 • 236 citations

Macrophage-derived IL-18–mediated intestinal inflammation in the murine model of Crohn's disease

2001 • 196 citations

Role of GITR in activation response of T lymphocytes

2002 • 169 citations

NKT Cells Inhibit the Onset of Diabetes by Impairing the Development of Pathogenic T Cells Specific for Pancreatic β Cells

2002 • 163 citations

CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti–Myelin Basic Protein T Cell Receptor Transgenic Mice

1998 • 159 citations

Prevention of Experimental Colitis in SCID Mice Reconstituted with CD45RBhigh CD4+ T Cells by Blocking the CD40-CD154 Interactions

2000 • 125 citations

Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration

2000 • 99 citations

T-cell function and specificity in athymic mice

1983 • 90 citations

Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation.

1995 • 85 citations

Cutaneous Inflammatory Disorder in Integrin αE (CD103)-Deficient Mice

2000 • 76 citations

Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis

2003 • 69 citations

Control of Experimental Inflammatory Bowel Disease by Regulatory T cells

2000 • 63 citations

Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: implications for autoimmunity and tumor immunity

2001 • 57 citations

The puzzling world of murine T regulatory cells

2002 • 30 citations

Phenotypic and Functional Characteristics of ‘T-Like’ Cells in Nude Mice

1984 • 28 citations

Immunoregulatory functions of mucosal γδ T cells

1999 • 7 citations