Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

The Primary Immunodeficiencies

1984 • 1,111 citations

Redistribution and Pinocytosis of Lymphocyte Surface Immunoglobulin Molecules Induced by Anti-Immunoglobulin Antibody

1971 • 1,093 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

1996 • 1,062 citations

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

1994 • 1,053 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Wiskott-Aldrich syndrome

1968 • 422 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

1997 • 376 citations

The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets

1980 • 327 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

The Primary Immunodeficiencies

1995 • 311 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

Bee1, a Yeast Protein with Homology to Wiscott-Aldrich Syndrome Protein, Is Critical for the Assembly of Cortical Actin Cytoskeleton

1997 • 252 citations

Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia: WASP Gene Mutations, Protein Expression, and Phenotype

1997 • 252 citations

Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent Mechanism

1998 • 247 citations

Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.

1996 • 229 citations

The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene

1995 • 211 citations

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

1996 • 209 citations

Defective Actin Reorganization and Polymerization of Wiskott-Aldrich T Cells in Response to CD3-Mediated Stimulation

1997 • 206 citations

T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses.

1993 • 197 citations

THE WISKOTT-ALDRICH SYNDROME A DISORDER WITH A POSSIBLE DEFECT IN ANTIGEN PROCESSING OR RECOGNITION

1968 • 197 citations

Identification of Itk/Tsk Src Homology 3 Domain Ligands

1996 • 193 citations

Inhibition and reversal of capping by cytochalasin B, yinblastine and colchicine

1974 • 188 citations

Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticus.

1996 • 184 citations

Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora

1997 • 169 citations

Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases

1996 • 154 citations

WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia

1995 • 151 citations

Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome

1986 • 143 citations

T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome.

1992 • 141 citations

Tyrosine Phosphorylation Regulates the SH3-mediated Binding of the Wiskott-Aldrich Syndrome Protein to PSTPIP, a Cytoskeletal-associated Protein

1998 • 137 citations

Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes.

1992 • 131 citations

Defects in Wiskott-Aldrich syndrome blood cells

1996 • 122 citations

GENETIC STUDIES BY RECORD LINKAGE

1965 • 114 citations

Actin polymerization and pseudopod reorganization accompany anti-CD3-induced growth arrest in Jurkat T cells.

1993 • 112 citations

The Wiskott-Aldrich syndrome

1998 • 110 citations

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.

1996 • 109 citations

Identification of mutations in the Wiskott-Aldrich syndrome gene and characterization of a polymorphic dinucleotide repeat at DXS6940, adjacent to the disease gene.

1995 • 104 citations

Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome.

1992 • 91 citations

WASPbase: a database of WAS- and XLT-causing mutations

1996 • 89 citations

Identification of Regions of the Wiskott-Aldrich Syndrome Protein Responsible for Association with Selected Src Homology 3 Domains

1996 • 71 citations

Role of cytokines in the early stages of chronic colitis in TCR alpha-mutant mice.

1997 • 61 citations

Localization of the gene for the Wiskott-Aldrich syndrome between two flanking markers, TIMP and DXS255, on Xp11.22–Xp11.3

1991 • 60 citations

Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients.

1997 • 52 citations

Capping of human T cell specific determinants: kinetics of capping and receptor re-expression and regulation by the cytoskeleton

1983 • 51 citations

Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes.

1991 • 48 citations

Scanning of the Wiskott-Aldrich syndrome (WAS) gene: identification of 18 novel alterations including a possible mutation hotspot at Arg86 resulting in thrombocytopenia, a mild WAS phenotype

1995 • 47 citations

The Mouse Homolog of the Wiskott–Aldrich Syndrome Protein (WASP) Gene Is Highly Conserved and Maps near the Scurfy (sf) Mutation on the X Chromosome

1995 • 46 citations

Capping of human T cell specific determinants: kinetics of capping and receptor re-expression and regulation by the cytoskeleton.

1983 • 43 citations

Wiskott-Aldrich syndrome and inflammatory bowel disease.

1988 • 28 citations

cAMP accumulation in T-cells inhibits anti-CD3 monoclonal antibody-induced actin polymerization

1995 • 27 citations

WASPbase: a database of WAS- and XLT-causing mutations

1996 • 24 citations

Antigen receptor-mediated transmembrane signaling in Wiskott-Aldrich syndrome.

1994 • 22 citations

Engagement of the T‐cell antigen receptor by anti‐CD3 monoclonal antibody causes a rapid increase in lymphocyte F‐actin

1994 • 22 citations

Probing the gastrointestinal immune function using transgenic and knockout technology

1996 • 18 citations