Virus-Induced Activation of Self-Specific TCRαβ CD8αα Intraepithelial Lymphocytes Does Not Abolish Their Self-Tolerance in the Intestine

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

The enemy within: keeping self-reactive T cells at bay in the periphery

2002 • 586 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

The Interrelated Roles of TGF-β and IL-10 in the Regulation of Experimental Colitis

2002 • 267 citations

T Cell Responses Modulated Through Interaction Between CD8αα and the Nonclassical MHC Class I Molecule, TL

2001 • 257 citations

A Unique Subset of Self-specific Intraintestinal T Cells Maintains Gut Integrity

2002 • 227 citations

TGF-beta promotes immune deviation by altering accessory signals of antigen-presenting cells.

1998 • 217 citations

Intrathymic and extrathymic clonal deletion of T cells

1995 • 201 citations

Precursors of Functional MHC Class I- or Class II-Restricted CD8αα+ T Cells Are Positively Selected in the Thymus by Agonist Self-Peptides

2002 • 201 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

Extrathymic T Cell Lymphopoiesis

2003 • 180 citations

Infection breaks T-cell tolerance

1992 • 174 citations

Regional specialization of the mucosal immune system. Intraepithelial lymphocytes of the large intestine have a different phenotype and function than those of the small intestine.

1993 • 164 citations

Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut.

1992 • 163 citations

Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology

1998 • 161 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

TGF-β Promotes Immune Deviation by Altering Accessory Signals of Antigen-Presenting Cells

1998 • 155 citations

Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine.

1996 • 151 citations

Extrathymic intestinal T-cell development: virtual reality?

1995 • 149 citations

Expression of Intestine-Specific Antigen Reveals Novel Pathways of CD8 T Cell Tolerance Induction

2000 • 138 citations

Toxoplasma gondii oral infection induces specific cytotoxic CD8 alpha/beta+ Thy-1+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes.

1994 • 123 citations

Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation.

1994 • 120 citations

Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection

1989 • 114 citations

Activation and migration of CD8 T cells in the intestinal mucosa.

1997 • 102 citations

Intestinal Intraepithelial Lymphocytes Exert Potent Protective Cytotoxic Activity During an Acute Virus Infection

2000 • 98 citations

Selection and Expansion of CD8α/α1 T Cell Receptor α/β1 Intestinal Intraepithelial Lymphocytes in the Absence of Both Classical Major Histocompatibility Complex Class I and Nonclassical Cd1 Molecules

1999 • 97 citations

Adoptive transfer of gut intraepithelial lymphocytes protects against murine infection with Toxoplasma gondii.

1997 • 85 citations

Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor alpha/beta in the intestinal epithelium.

1993 • 80 citations

Gut intraepithelial lymphocyte development

2002 • 79 citations

Cutting Edge: Inflammatory Signals Drive Organ-Specific Autoimmunity to Normally Cross-Tolerizing Endogenous Antigen

2002 • 75 citations

Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules.

1999 • 70 citations

An Opposite Pattern of Selection of a Single T Cell Antigen Receptor in the Thymus and among Intraepithelial Lymphocytes

1998 • 67 citations

Cutting Edge: TCRαβ+ CD8αα+ T Cells Are Found in Intestinal Intraepithelial Lymphocytes of Mice That Lack Classical MHC Class I Molecules

1999 • 65 citations

Regulation of cell death and survival in intestinal intraepithelial lymphocytes

2001 • 54 citations

High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8αα and CD8αβ T lymphocytes

1999 • 48 citations

Generation of Intestinal Mucosal Lymphocytes in SCID Mice Reconstituted with Mature, Thymus-Derived T Cells

1998 • 44 citations

Intestinal Intraepithelial Lymphocytes Respond to Systemic Lymphocytic Choriomeningitis Virus Infection

1996 • 39 citations

Differential Contribution of Fas- and Perforin-Mediated Mechanisms to the Cell-Mediated Cytotoxic Activity of Naive and In Vivo-Primed Intestinal Intraepithelial Lymphocytes

2000 • 38 citations

Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts.

1996 • 35 citations

Contribution of double-negative thymic precursors to CD8α α+ intraepithelial lymphocytes of the gut in mice bearing TCR transgenes

2001 • 30 citations

Increased Threshold for TCR-Mediated Signaling Controls Self Reactivity of Intraepithelial Lymphocytes

1998 • 16 citations

MHC Class I Allele Dosage Alters CD8 Expression by Intestinal Intraepithelial Lymphocytes

2001 • 9 citations