The Generation and Selection of the T Cell Repertoire: Insights from Studies of the Molecular Basis of T Cell Recognition

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Identification of a putative second T-cell receptor

1986 • 980 citations

The somatic generation of immune recognition

1971 • 974 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

The Relation Between Major Histocompatibility Complex (MHC) Restriction and the Capacity of Ia to Bind Immunogenic Peptides

1987 • 696 citations

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

1984 • 652 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level”

2015 • 572 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1982 • 494 citations

A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes.

1978 • 488 citations

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

1987 • 483 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

Why do so many lymphocytes respond to major histocompatibility antigens?

1977 • 462 citations

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.

1984 • 455 citations

T cell antigen receptors and the immunoglobulin supergene family

1985 • 453 citations

A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes

1986 • 430 citations

A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product

1987 • 408 citations

Regulation of the Assembly and Expression of Variable-Region Genes

1986 • 402 citations

A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family

1987 • 397 citations

Structure, organization, and somatic rearrangement of T cell gamma genes

1985 • 395 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

Structural Basis of Antibody Function

1983 • 371 citations

Differential expression of two distinct T-cell receptors during thymocyte development

1987 • 360 citations

Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

1978 • 353 citations

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

1985 • 299 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

Murine Major Histocompatibility Complex Class-I Mutants: Molecular Analysis and Structure-Function Implications

1986 • 286 citations

The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments

1985 • 283 citations

Immunological self/nonself discrimination

1999 • 265 citations

Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

1987 • 247 citations

Characterization of murine thymocytes with CDS-associated T-cell receptor structures

1987 • 245 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

Cell growth cycle block of T cell hybridomas upon activation with antigen.

1987 • 235 citations

Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

1987 • 230 citations

The Antigen-Specific, Major Histocompatibility Complex-Restricted Receptor on T Cells

1986 • 225 citations

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

1987 • 220 citations

Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes

1987 • 220 citations

Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development

1987 • 218 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

Predominant use of a Vα gene segment in mouse T-cell receptors for cytochrome c

1986 • 206 citations

Characterization of T Cell Receptor Gamma Chain Expression in a Subset of Murine Thymocytes

1986 • 199 citations

The T cell receptor: the α and β chains define idiotype, and antigen and MHC specificity

1985 • 198 citations

Two Different V_H Gene Products Make Up the T‐Cell Receptors

1976 • 179 citations

Transfection of the CD8 gene enhances T-cell recognition

1987 • 177 citations

Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer.

1986 • 168 citations

Characterization and expression of the human alpha beta T cell receptor by using a framework monoclonal antibody.

1987 • 162 citations

Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex

1987 • 159 citations

Major Transplantation Antigens, Viruses, and Specificity of Surveillance T Cells

1977 • 135 citations

Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures.

1983 • 133 citations

The T cell repertoire may be biased in favor of MHC recognition

1986 • 121 citations

Rearranged β t cell receptor genes in a helper t cell clone specific for lysozyme: No correlation between Vβ and MHC restriction

1985 • 120 citations

Cell-mediated immunity and the major histocompatibility complex

1978 • 119 citations

Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure-function relationships.

1987 • 107 citations

Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c.

1987 • 104 citations

Analysis of the Expression and Function of Class-II Major Histocompatibility Complex-Encoded Molecules by DNA-Mediated Gene Transfer

1986 • 96 citations

Functionally distinct subsites on a class II major histocompatibility complex molecule

1987 • 95 citations

SPECIFICITY OF RECOMBINATION OF H AND L CHAINS FROM HUMAN γG-MYELOMA PROTEINS

1965 • 91 citations

Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone

1987 • 89 citations

Correlation of T cell receptor V beta gene family with MHC restriction.

1987 • 87 citations

T-cell inhibition of humoral responsiveness

1978 • 86 citations

Identical Vβ T-cell receptor genes used in alloreactive cytotoxic and antigen plus I–A specific helper T cells

1985 • 79 citations

A Dual Recognition Model for Cytotoxic T Cells Based on Thymic Selection of Precursors with Low Affinity for Self H‐2 Antigens

1978 • 77 citations

T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten-specific cytotoxic T cell clones.

1987 • 68 citations

Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor.

1987 • 58 citations

Predictable acquisition of a new MHC recognition specificity following expression of a transfected T-cell receptor β-chain gene

1987 • 58 citations

Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex alpha beta dimer expression.

1987 • 57 citations

The T-cell receptor mediating restrictive recognition of antigen

1983 • 57 citations

I-A-restricted T cell antigen recognition. Analysis of the roles of A alpha and A beta using DNA-mediated gene transfer.

1986 • 56 citations

T-cell antigen receptors with identical variable regions but different diversity and joining region gene segments have distinct specificities but cross-reactive idiotypes.

1987 • 44 citations

Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice.

1987 • 42 citations

The unfolding story of T cell receptor γ

1987 • 41 citations

Variability in the Specific Interactions of H and L Chains of γG-Globulins^*

1967 • 39 citations

Characterization of an Lyt-2+ alloreactive cytotoxic T cell clone specific for H-2Db that cross-reacts with I-Ek.

1986 • 35 citations

Independent association of T cell receptor beta and gamma chains with CD3 in the same cell.

1987 • 35 citations

The peptidic self model: a reassessment of the role of the major histocompatibility complex molecules in the restriction of the T-cell response.

1986 • 32 citations

Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer.

1987 • 21 citations

Cytolytic T cell hybridomas: III. The antigen specificity and the restriction specificity of cytolytic T cells do not phenotypically mix

1985 • 17 citations

T cells recognize antigen alone and not MHC molecules

1987 • 17 citations

A random repertoire of V genes for T-cell receptors? Theoretical implications of recent experimental observations on T-cell specificity and self-restriction

1981 • 11 citations

Recherche préliminaire d'anticorps anti-lavdans des groupes de population exposés au risqueá madagascar

1986 • 10 citations

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