The effects of MHC gene dosage and allelic variation on T cell receptor selection

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Natural history of the major histo-compatibility complex

1987 • 1,274 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice.

1983 • 810 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Specificity pockets for the side chains of peptide antigens in HLA-Aw68

1989 • 664 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

The T Cell Receptor

1987 • 554 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

The operator-binding domain of λ repressor: structure and DNA recognition

1982 • 528 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

On the conformation of the hen egg-white lysozyme molecule

1967 • 429 citations

A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product

1987 • 408 citations

T Cell Selection in the Thymus

1988 • 405 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

THYMUS CELL MIGRATION

1967 • 356 citations

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

1989 • 310 citations

Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells.

1985 • 305 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

The murine Eα immune response gene

1983 • 180 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

T-lymphocyte response to cytochrome c. I. Demonstration of a T-cell heteroclitic proliferative response and identification of a topographic antigenic determinant on pigeon cytochrome c whose immune recognition requires two complementing major histocompatibility complex-linked immune response genes.

1979 • 172 citations

Correcting an immune-response deficiency by creating Eα gene transgenic mice

1985 • 171 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Intrathymic maturation of murine T lymphocytes from CD8+ precursors.

1989 • 134 citations

The nucleotide sequence of the murine I-E beta b immune response gene: evidence for gene conversion events in class II genes of the major histocompatibility complex.

1984 • 131 citations

Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in A(e):E(a), complex expression causes a corresponding defect in antigen-presenting cell function

1982 • 115 citations

Thymic cortical epithelial cells can present self-antigens in vivo

1989 • 108 citations

Functionally distinct subsites on a class II major histocompatibility complex molecule

1987 • 95 citations

DNA Sequence of the Gene Encoding the E_αIa Polypeptide of the BALB/c Mouse

1982 • 85 citations

Thymic cortical epithelial cells lack full capacity for antigen presentation

1989 • 85 citations

Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain.

1983 • 81 citations

Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C.

1983 • 80 citations

CD4+ murine T cells develop from CD8+ precursors in vivo

1987 • 71 citations

Expression of T-cell receptor alpha-chain genes in transgenic mice.

1988 • 60 citations

Predictable acquisition of a new MHC recognition specificity following expression of a transfected T-cell receptor β-chain gene

1987 • 58 citations

The use of hydrophobic, alpha-helix-defined peptides in delineating the T cell determinant for pigeon cytochrome c.

1987 • 52 citations

The T lymphocyte response to cytochrome c—II.

1980 • 43 citations

Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.

1985 • 37 citations

The T‐Cell Receptor for Antigen in T‐Cell Development and Repertoire Selection

1988 • 37 citations

Two distinct mechanisms account for the immune response (Ir) gene control of the T cell response to pigeon cytochrome c.

1988 • 36 citations

The T lymphocyte response to cytochrome C. III. Relationship of the fine specificity of antigen recognition to major histocompatibility complex genotype.

1982 • 30 citations

Restricted assembly of MHC class II molecules in transgenic mice.

1989 • 30 citations

I-A alpha polymorphic residues that determine alloreactive T cell recognition.

1989 • 30 citations