The role of thymic epithelium in the acquisition of tolerance

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Graft Versus Host Reactions. Their Natural History, and Applicability as Tools of Research

2015 • 550 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

T Cell Selection in the Thymus

1988 • 405 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

The effect of thymus environment on T cell development and tolerance

1988 • 330 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Identity of cells that imprint H–2-restricted T-cell specificity in the thymus

1986 • 267 citations

Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage

1988 • 265 citations

Development of thymus, parathyroids, and ultimo‐branchial bodies in NMRI and nude mice

1980 • 264 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

Antigen presenting function of class II MHC expressing pancreatic beta cells

1988 • 255 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

Deletion of self-reactive T cells before entry into the thymus medulla

1988 • 171 citations

Tolerance Induced by Thymic Epithelial Grafts in Birds

1987 • 167 citations

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

1984 • 158 citations

T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells

1980 • 153 citations

Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.

1990 • 146 citations

Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens

1984 • 138 citations

Immunologic Tolerance: Collaboration Between Antigen and Lymphokines

1989 • 135 citations

Transgenic Mice with I-A on Islet Cells Are Normoglycemic But Immunologically Intolerant

1989 • 135 citations

Thymic Requirement for Clonal Deletion During T Cell Development

1989 • 95 citations

Cells expressing Ia antigens in the avian thymus.

1984 • 93 citations

Immune responses of thymusf/ymphocyte embryonic chimeras: studies on tolerance and major histocompatibility complex restriction in Xenopus

1985 • 90 citations

Thymic cortical epithelial cells lack full capacity for antigen presentation

1989 • 85 citations

Failure of T Cell Receptor V _β Negative Selection in an Athymic Environment

1989 • 76 citations

Thymic epithelium and the induction of transplantation tolerance in nude mice

1985 • 64 citations

Tolerize one, tolerize them all: tolerance is self-assertion

1989 • 44 citations

Peripheral tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses

1989 • 44 citations

Implants of quail thymic epithelium generate permanent tolerance in embryonically constructed quail/chick chimeras

1988 • 42 citations

Split tolerance induced by chick embryo thymic epithelium allografted to embryonic recipients.

1986 • 37 citations

Thymic epithelium tolerizes chickens to embryonic grafts of quail bursa of Fabricius

1989 • 33 citations

IMPAIRED REJECTION OF MINOR-HISTOCOMPATIBILITYANTIGEN–DISPARATE SKIN GRAFTS AND ACQUISITION OF TOLERANCE TO THYMUS DONOR ANTIGENS IN ALLOTHYMUS-IMPLANTED, THYMECTOMIZED XENOPUS

1986 • 18 citations

Induction of T cell differentiation in early-thymectomized Xenopus by grafting adult thymuses from either MHC-matched or from partially or totally MHC-mismatched donors.

1984 • 13 citations

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