11β-Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

2001 • 1,743 citations

Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity

1987 • 1,218 citations

LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

1988 • 1,047 citations

The Basophil Adenomas of the Pituitary Body and Their Clinical Manifestations (Pituitary Basophilism)

1964 • 853 citations

11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

1997 • 851 citations

Does central obesity reflect “Cushing's disease of the omentum”?

1997 • 755 citations

Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme

1994 • 707 citations

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity

2001 • 634 citations

Human hypertension caused by mutations in the kidney isozyme of 11β–hydroxysteroid dehydrogenase

1995 • 621 citations

The neuronal mineralocorticoid eeceptor as a mediator of glucocorticoid response

1988 • 576 citations

Glucose‐6‐phosphate dehydrogenase: a “housekeeping” enzyme subject to tissue‐specific regulation by hormones, nutrients, and oxidant stress

1994 • 534 citations

11β-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess*

1997 • 515 citations

Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.

1983 • 515 citations

A Syndrome of Apparent Mineralocorticoid Excess Associated with Defects in the Peripheral Metabolism of Cortisol*

1979 • 490 citations

Cloning and Expression of Rat cDNA Encoding Corticosteroid 11β-Dehydrogenase

1989 • 452 citations

Characteristics of short‐chain alcohol dehydrogenases and related enzymes

1991 • 452 citations

Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis.

1996 • 448 citations

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

1991 • 434 citations

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.

1988 • 420 citations

Cortisol Metabolism in Human Obesity: Impaired Cortisone→Cortisol Conversion in Subjects with Central Adiposity¹

1999 • 406 citations

Mechanisms of Glucocorticoid Action in Bone

2002 • 389 citations

Glucocorticoids and Insulin Promote the Differentiation of Human Adipocyte Precursor Cells into Fat Cells

1987 • 311 citations

Purification and Characterization of the Corticosteroid 1lβ-Dehydrogenase Component of the Rat Liver 1lβ-Hydroxysteroid Dehydrogenase Complex*

1988 • 308 citations

11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations.

1995 • 301 citations

Hypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2

1999 • 282 citations

Urinary free cortisone and the assessment of 11β‐hydroxysteroid dehydrogenase activity in man

1996 • 269 citations

Glucocorticoid Receptor-Mediated Cell Cycle Arrest Is Achieved through Distinct Cell-Specific Transcriptional Regulatory Mechanisms

1997 • 266 citations

11Beta-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction

1998 • 264 citations

Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice

2002 • 263 citations

Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform.

1993 • 263 citations

Adipose tissue distribution and plasma lipoprotein levels in obese women. Importance of intra-abdominal fat.

1989 • 259 citations

Differentiation of Adipose Stromal Cells: The Roles of Glucocorticoids and 11β-Hydroxysteroid Dehydrogenase*

1999 • 251 citations

NAD(+)-dependent isoform of 11 beta-hydroxysteroid dehydrogenase. Cloning and characterization of cDNA from sheep kidney

1994 • 246 citations

Expression of the mRNA Coding for 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue from Obese Patients: Anin SituHybridization Study

2002 • 245 citations

Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta.

1995 • 243 citations

Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene

1996 • 235 citations

Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Activity and Messenger Ribonucleic Acid Levels Are Associated with Adiposity and Insulinemia in Pima Indians and Caucasians

2003 • 226 citations

Modulation of 11β-Hydroxysteroid Dehydrogenase Isozymes by Proinflammatory Cytokines in Osteoblasts: An Autocrine Switch from Glucocorticoid Inactivation to Activation

2001 • 224 citations

Arylsulfonamidothiazoles as a New Class of Potential Antidiabetic Drugs. Discovery of Potent and Selective Inhibitors of the 11β-Hydroxysteroid Dehydrogenase Type 1

2002 • 214 citations

Peroxisome Proliferator-activated Receptor-γ Ligands Inhibit Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity

2001 • 212 citations

11 -Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess

1997 • 206 citations

A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess.

1995 • 200 citations

Immunohistochemical Localization of Type 1 11β-Hydroxysteroid Dehydrogenase in Human Tissues1

1998 • 198 citations

Osteoblastic 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Increases With Age and Glucocorticoid Exposure

2002 • 193 citations

Hyperandrogenism in Polycystic Ovary Syndrome -- Evidence of Dysregulation of 11β-Hydroxysteroid Dehydrogenase

1994 • 193 citations

Cloning and production of antisera to human placental 11 β-hydroxysteroid dehydrogenase type 2

1996 • 191 citations

The N-terminal Anchor Sequences of 11β-Hydroxysteroid Dehydrogenases Determine Their Orientation in the Endoplasmic Reticulum Membrane

1999 • 190 citations

11β-Hydroxysteroid Dehydrogenase

1993 • 189 citations

Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue Is Not Increased in Human Obesity

2002 • 189 citations

5 α-reductase activity in polycystic ovary syndrome

1990 • 188 citations

Examination of Genotype and Phenotype Relationships in 14 Patients with Apparent Mineralocorticoid Excess¹

1998 • 177 citations

Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform.

1994 • 176 citations

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats

1995 • 174 citations

Deficient inactivation of cortisol by 11β‐hydroxysteroid dehydrogenase in essential hypertension

1993 • 173 citations

11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity

1996 • 172 citations

Glucocorticoid Receptors and Inhibition of Bone Cell Growth in Primary Culture¹²

1977 • 167 citations

Differential Expression of 11β-Hydroxysteroid Dehydrogenase Types 1 and 2 in Human Placenta and Fetal Membranes¹

1997 • 164 citations

Evidence of Coexisting Changes in 11β-Hydroxysteroid Dehydrogenase and 5β-Reductase Activity in Subjects With Untreated Essential Hypertension

1995 • 161 citations

Expression of 11β-Hydroxysteroid Dehydrogenase Using Recombinant Vaccinia Virus

1990 • 158 citations

Expression and functional consequences of 11β-hydroxysteroid dehydrogenase activity in human bone

2000 • 157 citations

11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Lean and Obese Males with Type 2 Diabetes Mellitus

2004 • 155 citations

Cortisol metabolism and the role of 11β-hydroxysteroid dehydrogenase

2001 • 150 citations

11 beta-Hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells.

1994 • 149 citations

The Syndrome of Apparent Mineralocorticoid Excess: Its Association with 1 lβ –Dehydrogenase and 5β –Reductase Deficiency and Some Consequences for Corticosteroid Metabolism*

1986 • 143 citations

Several homozygous mutations in the gene for 11 beta-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess.

1995 • 138 citations

A genetic defect resulting in mild low-renin hypertension

1998 • 135 citations

CA-Repeat Polymorphism in Intron 1 of HSD11B2

2000 • 133 citations

In Vivo 11β-HSD-2 Activity

2001 • 132 citations

Examination of Genotype and Phenotype Relationships in 14 Patients with Apparent Mineralocorticoid Excess

1998 • 129 citations

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity

2001 • 122 citations

Lumenal Orientation and Post-translational Modifications of the Liver Microsomal 11 -Hydroxysteroid Dehydrogenase

1995 • 117 citations

Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11 beta-hydroxysteroid dehydrogenase.

1995 • 114 citations

The Production Rate of Cortisol in Man

1958 • 112 citations

Down-Regulation of Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 by High-Fat Feeding in Mice: A Potential Adaptive Mechanism Counteracting Metabolic Disease

2004 • 112 citations

Steroid 11β-ol Dehydrogenase in Human Placenta

1960 • 109 citations

Type 2 11β-hydroxysteroid dehydrogenase in foetal and adult life

1995 • 108 citations

THE KIDNEY IS THE MAJOR SITE OF CORTISONE PRODUCTION IN MAN

1989 • 108 citations

Detection of human 11β-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts

1995 • 106 citations

Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver

1968 • 105 citations

CONGENITAL 11β‐HYDROXYSTEROID DEHYDROGENASE DEFICIENCY ASSOCIATED WITH JUVENILE HYPERTENSION: CORTICOSTEROID METABOLITE PROFILES OF FOUR PATIENTS AND THEIR FAMILIES

1985 • 102 citations

Apparent Cortisone Reductase Deficiency: A Functional Defect in 11β-Hydroxysteroid Dehydrogenase Type 1*

1999 • 102 citations

Molecular Basis for Hypertension in the “Type II Variant” of Apparent Mineralocorticoid Excess

1998 • 101 citations

Defects in the HSD11 gene encoding 11 beta-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid excess or 11-oxoreductase deficiency.

1993 • 99 citations

11β-hydroxysteroid dehydrogenase activity (E.C. 1.1.1.146) in human placenta and decidua

1980 • 97 citations

Colocalization of Glucocorticoid and Mineralocorticoid Receptors in Human Bone

2001 • 96 citations

PPARα Agonists Reduce 11β-Hydroxysteroid Dehydrogenase Type 1 in the Liver

2000 • 94 citations

Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.

1993 • 92 citations

Localization of 11beta-hydroxysteroid dehydrogenase type 2 in rat tissues: in situ studies.

1996 • 86 citations

Weight Loss Increases 11β-Hydroxysteroid Dehydrogenase Type 1 Expression in Human Adipose Tissue

2004 • 86 citations

Apparent Mineralocorticoid Excess

1996 • 86 citations

Prereceptor regulation of glucocorticoid action by 11β‐hydroxysteroid dehydrogenase: a novel determinant of cell proliferation

2002 • 85 citations

THE SEPARATION AND IDENTIFICATION OF MIXTURES OF C21 AND C19 STEROIDS BY PAPER CHROMATOGRAPHY

1953 • 85 citations

Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development.

1992 • 85 citations

Epithelial cell localization of type 2 11 beta-hydroxysteroid dehydrogenase in rat and human colon.

1994 • 84 citations

11β‐Hydroxysteroid dehydrogenase: implications for clinical medicine

1996 • 83 citations

Apparent cortisone reductase deficiency: a unique form of hypercortisolism.

1996 • 83 citations

Glucocorticoids reversibly arrest rat hepatoma cell growth by inducing an early G1 block in cell cycle progression.

1993 • 83 citations

11β-Hydroxysteroid Dehydrogenase Type 1 from Human Liver: Dimerization and Enzyme Cooperativity Support Its Postulated Role as Glucocorticoid Reductase

2002 • 82 citations

Phenotypic analysis of mice bearing targeted deletions of 11β-hydroxysteroid dehydrogenases 1 and 2 genes

2001 • 80 citations

A new defect in the peripheral conversion of cortisone to cortisol

1985 • 79 citations

Evidence for kinetically distinct forms of corticosteroid 11β-dehydrogenase in rat liver microsomes

1989 • 78 citations

Human skin as target for aldosterone: coexpression of mineralocorticoid receptors and 11 beta-hydroxysteroid dehydrogenase.

1994 • 78 citations

A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess

1995 • 78 citations

Characterization of 11beta-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines

1999 • 78 citations

Apparent mineralocorticoid excess in a Brazilian kindred

1997 • 75 citations

Expression of 11β-Hydroxysteroid Dehydrogenase Isoenzymes in the Human Pituitary: Induction of the Type 2 Enzyme in Corticotropinomas and Other Pituitary Tumors

2001 • 75 citations

PHYSIOLOGICAL EFFECTS OF CORTISONE AND PITUITARY ADRENOCORTICOTROPIC HORMONE (ACTH) IN MAN

1950 • 74 citations

Renal Capture and Oxidation of Cortisol in Man¹

1971 • 74 citations

CONVERSION OF CORTISONE TO COMPOUND F

1953 • 72 citations

THE METABOLISM OF CORTISOL BY HUMAN EXTRA-HEPATIC TISSUES

1966 • 71 citations

Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues.

2000 • 68 citations

11β-Hydroxysteroid dehydrogenase in the rat placenta: developmental changes and the effects of altered glucocorticoid exposure

1994 • 67 citations

Functional Expression, Characterization, and Purification of the Catalytic Domain of Human 11-β-Hydroxysteroid Dehydrogenase Type 1

2001 • 65 citations

Mutants of 11β-Hydroxysteroid Dehydrogenase (11-HSD2) With Partial Activity

1999 • 63 citations

Cloning, sequencing and tissue-distribution of mouse 11β-hydroxysteroid dehydrogenase-1 cDNA

1995 • 62 citations

Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.

2001 • 60 citations

Expression cloning of the aldosterone target cell-specific 11 beta-hydroxysteroid dehydrogenase from rabbit collecting duct cells.

1995 • 60 citations

Bidirectional activity of 11β-hydroxysteroid dehydrogenase in vascular smooth muscle cells

1995 • 58 citations

Structural analysis and evaluation of the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) gene in human essential hypertension

1998 • 58 citations

Point mutations abolish 11β-hydroxysteroid dehydrogenase type II activity in three families with the congenital syndrome of apparent mineralocorticoid excess

1996 • 57 citations

11beta-hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells

1998 • 56 citations

Failure of Cortisone Acetate Treatment in Congenital Adrenal Hyperplasia because of Defective 11β-Hydroxysteroid Dehydrogenase Reductase Activity*

1999 • 53 citations

Ontogeny and sexual dimorphic expression of mouse type 2 11β-hydroxysteroid dehydrogenase

1997 • 50 citations

Expression of the 11β-Hydroxysteroid Dehydrogenase Types 1 and 2 Proteins in Human and Baboon Placental Syncytiotrophoblast

1999 • 50 citations

Nephrocalcinosis and renal cysts associated with apparent mineralocorticoid excess syndrome

2000 • 50 citations

A New Polymorphic Restriction Site in the Human 11β-Hydroxysteroid Dehydrogenase Type 2 Gene

1998 • 50 citations

Plasma Cortisone Concentration as Measured by Radioimmunoassay

1973 • 49 citations

Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11 beta-hydroxysteroid dehydrogenase

1995 • 49 citations

Increased 5α-Reductase and Normal 11β-Hydroxysteroid Dehydrogenase Metabolism of C19 and C21 Steroids in a Young Population with Polycystic Ovarian Syndrome

2000 • 47 citations

Polycystic ovary syndrome: an endocrine and metabolic disease

2000 • 47 citations

Human Hexose-6-phosphate Dehydrogenase (Glucose 1-Dehydrogenase) Encoded at 1p36: Coding Sequence and Expression

1999 • 47 citations

A Mutation in the Cofactor-Binding Domain of 11β-Hydroxysteroid Dehydrogenase Type 2 Associated with Mineralocorticoid Hypertension¹

2001 • 46 citations

Correlation of surfactant phosphatidylcholine synthesis and 11 beta-hydroxysteroid dehydrogenase in the fetal lung.

1995 • 46 citations

Purification, characterization and NNK carbonyl reductase activities of 11β-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen

2003 • 44 citations

Corticosteroid metabolism in vitro by humanplacenta, fetal membranes and decidua in early and late gestation

1981 • 43 citations

Differential Expression of 11 -Hydroxysteroid Dehydrogenase Types 1 and 2 in Human Placenta and Fetal Membranes

1997 • 43 citations

Apparent Cortisone Reductase Deficiency: A Rare Cause of Hyperandrogenemia and Hypercortisolism

2000 • 42 citations

Immunohistochemical distribution of 11β-hydroxysteroid dehydrogenase in human eye

2001 • 42 citations

Mutations in putative glycosylation sites of rat 11β-hydroxysteroid dehydrogenase affect enzymatic activity

1995 • 41 citations

Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development

1992 • 40 citations

Defects in the HSD11 gene encoding 11 beta-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid excess or 11- oxoreductase deficiency

1993 • 39 citations

A New Compound Heterozygous Mutation in the 11β-Hydroxysteroid Dehydrogenase Type 2 Gene in a Case of Apparent Mineralocorticoid Excess

1997 • 39 citations

Characterization of 11β-hydroxysteroid dehydrogenase of human placenta: Evidence for the existence of two species of 11β-hydroxysteroid dehydrogenase

1993 • 39 citations

Mineralocorticoid hypertension and congenital deficiency of 11β‐hydroxysteroid dehydrogenase in a family with the syndrome of‘apparent’mineralocorticoid excess

1995 • 39 citations

Low-Dose Growth Hormone Inhibits 11β-Hydroxysteroid Dehydrogenase Type 1 but Has No Effect upon Fat Mass in Patients with Simple Obesity

2003 • 38 citations

Apparent cortisone reductase deficiency: a unique form of hypercortisolism

1996 • 38 citations

THE CONVERSION OF CORTISONE ACETATE TO OTHER ALPHA-KETOLIC STEROIDS*†

1953 • 37 citations

Interconversion of Cortisol and Cortisone in Baboon Trophoblast and Decidua Cells in Culture*

1990 • 37 citations

Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance

1993 • 37 citations

Expression of 11?-hydroxysteroid dehydrogenase in rat osteoblastic cells: Pre-receptor regulation of glucocorticoid responses in bone

2001 • 36 citations

Expression of 11beta-hydroxysteroid dehydrogenases in bovine follicle and corpus luteum

2003 • 34 citations

Molecular basis for the Apparent Mineralocorticoid Excess Syndrome in the Oman population

2003 • 33 citations

Human 11β-Hydroxysteroid Dehydrogenase Type 1 Is Enzymatically Active in Its Nonglycosylated Form

2000 • 31 citations

Localization of 11beta-hydroxysteroid dehydrogenase type 2 in rat tissues: in situ studies

1996 • 31 citations

Human 11β-hydroxysteroid dehydrogenase 1/carbonyl reductase: recombinant expression in the yeast Pichia pastoris and Escherichia coli

2000 • 30 citations

Genetic, Biochemical, and Clinical Studies of Patients With A328V or R213C Mutations in 11βHSD2 Causing Apparent Mineralocorticoid Excess

1999 • 30 citations

Human skin as target for aldosterone: coexpression of mineralocorticoid receptors and 11 beta-hydroxysteroid dehydrogenase

1994 • 29 citations

Glucose Dehydrogenase (Hexose 6-Phosphate Dehydrogenase) and the Microsomal Electron Transport System

1979 • 28 citations

Renal 11 beta-hydroxysteroid dehydrogenase activity is enhanced by ramipril and captopril.

1994 • 27 citations

Comparative Enzymology of 11β-Hydroxysteroid Dehydrogenase Type 1 from Glucocorticoid Resistant (Guinea Pig) Versus Sensitive (Human) Species

2003 • 27 citations

Characteristics of short‐chain alcohol dehydrogenases and related enzymes

1991 • 25 citations

Analysis of the human gene encoding the kidney isozyme of 11β-hydroxysteroid dehydrogenase

1995 • 25 citations

A possible role for microsomal hexose-6-phosphate dehydrogenase in microsomal electron transport and mixed-function oxygenase activity

1979 • 24 citations

11β-Hydroxysteroid Dehydrogenase Type 1 Deficiency (‘Apparent Cortisone Reductase Deficiency’) in a 6-Year-Old Boy

2003 • 24 citations

Expression of 11β-hydroxysteroid dehydrogenase type 2 (11βHSD-2) in the developing human adrenal gland and human adrenal cortical carcinoma and adenoma

1999 • 24 citations

Expression cloning of the aldosterone target cell-specific 11 beta- hydroxysteroid dehydrogenase from rabbit collecting duct cells

1995 • 23 citations

Guinea pig 11β-hydroxysteroid dehydrogenase type 1: primary structure and catalytic properties☆

2000 • 21 citations

Purification of full-length recombinant human and rat type 1 11β-hydroxysteroid dehydrogenases with retained oxidoreductase activities

2002 • 21 citations

Genetic analysis of 11β-hydroxysteroid dehydrogenase

1994 • 20 citations

Prevalence of Mild Apparent Mineralocorticoid Excess in Mennonites

1999 • 19 citations

11β-Hydroxysteroid Dehydrogenase and Glucocorticoid Receptor Messenger RNA Expression in Porcine Placentae: Effects of Stage of Gestation, Breed, and Uterine Environment1

2003 • 19 citations

Serines at the Active Site of 11ß-Hydroxysteroid Dehydrogenase Type I Determine the Rate of Catalysis

1998 • 16 citations

Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy

2002 • 16 citations

In VitroExpression Studies of a Novel Mutation Δ299 in a Patient Affected with Apparent Mineralocorticoid Excess

2004 • 16 citations

A New Compound Heterozygous Mutation in the 11 -Hydroxysteroid Dehydrogenase Type 2 Gene in a Case of Apparent Mineralocorticoid Excess

1997 • 16 citations

The Codon 213 of the 11β-Hydroxysteroid Dehydrogenase Type 2 Gene Is a Hot Spot for Mutations in Apparent Mineralocorticoid Excess¹

1998 • 15 citations

Human hypertension caused by mutations in the 11 beta-hydroxysteroid dehydrogenase gene: a molecular analysis of apparent mineralocorticoid excess.

1996 • 13 citations

Expression of 11β-hydroxysteroid dehydrogenase type 2 in an ACTH-producing small cell lung cancer

1998 • 11 citations

Expression of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor in primary lung carcinomas.

2000 • 11 citations

TRANSCRIPTIONAL INFLUENCE OF TWO POLY PURINE-PYRIMIDINE TRACTS LOCATED IN THE HSD11B2 (11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2) GENE

2001 • 11 citations

Studies on the Glucocorticoid Feedback Control of ACTH Secretion

1968 • 10 citations

Prevalence of Mild Apparent Mineralocorticoid Excess in Mennonites

1999 • 10 citations

Renal 11 beta-hydroxysteroid dehydrogenase activity is enhanced by ramipril and captopril

1994 • 10 citations

Glucocorticoid receptors and inhibition of bone cell growth in primary culture.

1976 • 10 citations

The Production Rate of Cortisol in Man

1958 • 8 citations

Cortisone reductase (11 beta-hydroxysteroid dehydrogenase type 1) deficiency presenting with features of late onset congenital adrenal hyperplasia

2002 • 7 citations

A novel non-steroidal inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 improves features of metabolic syndrome in murine disease models

2004 • 5 citations