Osteoblastic 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Increases With Age and Glucocorticoid Exposure

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis*

2000 • 2,226 citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

2001 • 1,743 citations

Use of Inhaled Corticosteroids and Risk of Fractures

2001 • 1,339 citations

Alendronate for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis

1998 • 1,256 citations

Use of Oral Corticosteroids and Risk of Fractures

2000 • 1,181 citations

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

2000 • 1,175 citations

Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol.

1996 • 911 citations

Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis1

1999 • 779 citations

Does central obesity reflect “Cushing's disease of the omentum”?

1997 • 755 citations

11β-Hydroxysteroid Dehydrogenase

1997 • 725 citations

Human bone cellsin vitro

1985 • 696 citations

Intermittent Etidronate Therapy to Prevent Corticosteroid-Induced Osteoporosis

1997 • 688 citations

Glucocorticoids and insulin resistance: old hormones, new targets

1999 • 663 citations

Use of oral corticosteroids in the United Kingdom

2000 • 511 citations

Effects of Risedronate Treatment on Bone Density and Vertebral Fracture in Patients on Corticosteroid Therapy

2000 • 510 citations

Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis.

1996 • 448 citations

Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol

1996 • 307 citations

Comparison of Trabecular Bone Microarchitecture and Remodeling in Glucocorticoid-Induced and Postmenopausal Osteoporosis

2001 • 305 citations

11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations.

1995 • 301 citations

Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates

2001 • 272 citations

Differentiation of Adipose Stromal Cells: The Roles of Glucocorticoids and 11β-Hydroxysteroid Dehydrogenase*

1999 • 251 citations

Modulation of 11β-Hydroxysteroid Dehydrogenase Isozymes by Proinflammatory Cytokines in Osteoblasts: An Autocrine Switch from Glucocorticoid Inactivation to Activation

2001 • 224 citations

Age- and sex-related changes in iliac cortical bone mass and remodeling

1993 • 204 citations

Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis

1996 • 175 citations

Magnitude and Impact of Osteoporosis and Fractures

2001 • 175 citations

Mineralocorticoid excess and inhibition of 11 β‐hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome

1992 • 169 citations

Expression and functional consequences of 11β-hydroxysteroid dehydrogenase activity in human bone

2000 • 157 citations

Delivery and Transport of Glucocorticoids to Target Cells

1979 • 140 citations

Effects of prednisone and deflazacort on mineral metabolism and parathyroid hormone activity in humans

1984 • 134 citations

Conversion of cortisone to cortisol and prednisone to prednisolone.

1967 • 133 citations

Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: A review

1980 • 126 citations

Regulation of 1lβ-Hydroxysteroid Dehydrogenase Activity in Human Skin Fibroblasts: Enzymatic Modulation of Glucocorticoid Action*

1991 • 124 citations

11β-hydroxysteroid dehydrogenase 1 in adipocytes: Expression is differentiation-dependent and hormonally regulated

1998 • 119 citations

Bone loss after glucocorticoid therapy

1984 • 106 citations

Changes in quantitative bone histomorphometry in aging healthy men.

1996 • 104 citations

Human 11β-hydroxysteroid dehydrogenase: Studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue

1997 • 100 citations

Prereceptor regulation of glucocorticoid action by 11β‐hydroxysteroid dehydrogenase: a novel determinant of cell proliferation

2002 • 85 citations

Characterization of 11beta-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines

1999 • 78 citations

Selective inhibition of human type 1 11β‐hydroxysteroid dehydrogenase by synthetic steroids and xenobiotics

1998 • 61 citations

Effects of DeflazacortVersusPrednisone on Bone Mass, Body Composition, and Lipid Profile: A Randomized, Double Blind Study in Kidney Transplant Patients¹

1998 • 60 citations

Influence of Skeletal Site of Origin and Donor Age on Osteoblastic Cell Growth and Differentiation

1999 • 54 citations

Changes in quantitative bone histomorphometry in aging healthy men

1996 • 54 citations

Tissue- and temporal-specific regulation of 11β-hydroxysteroid dehydrogenase type 1 by glucocorticoids in vivo

1999 • 52 citations

Effect of growth hormone, insulin and dexamethasone on 11 β -hydroxysteroid dehydrogenase activity on a primary culture of rat hepatocytes

1996 • 48 citations

Effects of Deflazacort Versus Prednisone on Bone Mass, Body Composition, and Lipid Profile: A Randomized, Double Blind Study in Kidney Transplant Patients

1998 • 37 citations

Expression of 11?-hydroxysteroid dehydrogenase in rat osteoblastic cells: Pre-receptor regulation of glucocorticoid responses in bone

2001 • 36 citations

Deflazacort - an alternative to prednisolone?

1999 • 9 citations

A Non-Isotopic Method for Estimating 11β Hydroxysteroid Dehydrogenase Activity In Vivo

1997 • 2 citations