Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Activity and Messenger Ribonucleic Acid Levels Are Associated with Adiposity and Insulinemia in Pima Indians and Caucasians

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1985 • 29,733 citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

2001 • 1,743 citations

Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity and Endocrine, Metabolic and Hemodynamic Abnormalities¹

1998 • 887 citations

11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

1997 • 851 citations

The role of TNFα and TNF receptors in obesity and insulin resistance

1999 • 771 citations

Does central obesity reflect “Cushing's disease of the omentum”?

1997 • 755 citations

Minireview: 11β-Hydroxysteroid Dehydrogenase Type 1— A Tissue-Specific Amplifier of Glucocorticoid Action¹

2001 • 712 citations

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity

2001 • 634 citations

Elevated Plasma Cortisol Concentrations: A Link between Low Birth Weight and the Insulin Resistance Syndrome?1

1998 • 602 citations

Diabetes mellitus in the pima indians: Incidence, risk factors and pathogenesis

1990 • 590 citations

Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity and Endocrine, Metabolic and Hemodynamic Abnormalities

1998 • 554 citations

Evaluation of Simple Indices of Insulin Sensitivity and Insulin Secretion for Use in Epidemioiogic Studies

2000 • 471 citations

Cloning and Expression of Rat cDNA Encoding Corticosteroid 11β-Dehydrogenase

1989 • 452 citations

Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice

2001 • 435 citations

Cortisol Metabolism in Human Obesity: Impaired Cortisone→Cortisol Conversion in Subjects with Central Adiposity¹

1999 • 406 citations

Tissue-Specific Changes in Peripheral Cortisol Metabolism in Obese Women: Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Activity

2002 • 388 citations

Cortisol Effects on Body Mass, Blood Pressure, and Cholesterol in the General Population

1999 • 366 citations

Understanding the Role of Glucocorticoids in Obesity: Tissue-Specific Alterations of Corticosterone Metabolism in Obese Zucker Rats1

2000 • 340 citations

Obesity and Gender Influence Cortisol Secretion and Metabolism in Man

1998 • 331 citations

Elevated Plasma Cortisol Concentrations: A Link between Low Birth Weight and the Insulin Resistance Syndrome?

1998 • 325 citations

11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations.

1995 • 301 citations

Obesity in the Pima Indians: its magnitude and relationship with diabetes

1991 • 290 citations

Use of dual-energy X-ray absorptiometry in obese individuals

1995 • 258 citations

Expression of the mRNA Coding for 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue from Obese Patients: Anin SituHybridization Study

2002 • 245 citations

Regulation of Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue: Tissue-Specific Induction by Cytokines*

2001 • 223 citations

Peroxisome Proliferator-activated Receptor-γ Ligands Inhibit Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity

2001 • 212 citations

Abnormal Cortisol Metabolism and Tissue Sensitivity to Cortisol in Patients with Glucose Intolerance

2002 • 196 citations

Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue Is Not Increased in Human Obesity

2002 • 189 citations

Independent effects of obesity and cortisol in predicting cardiovascular risk factors in men and women

2000 • 153 citations

Regulation of 1lβ-Hydroxysteroid Dehydrogenase Activity in Human Skin Fibroblasts: Enzymatic Modulation of Glucocorticoid Action*

1991 • 124 citations

11β-hydroxysteroid dehydrogenase 1 in adipocytes: Expression is differentiation-dependent and hormonally regulated

1998 • 119 citations

THE KIDNEY IS THE MAJOR SITE OF CORTISONE PRODUCTION IN MAN

1989 • 108 citations

Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats

2000 • 88 citations

11β-Hydroxysteroid Dehydrogenase Activity in Hypothalamic Obesity

2003 • 77 citations

Modulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Mature Human Subcutaneous Adipocytes by Hypothalamic Messengers

2003 • 73 citations

Glucocorticoid Receptor Messenger Ribonucleic Acid in Different Regions of Human Adipose Tissue*

1990 • 73 citations

An in vivo study of the cortisol–cortisone shuttle in subcutaneous abdominal adipose tissue

1999 • 66 citations

Visceral adipose tissue is not increased in Pima Indians compared with equally obese Caucasians and is not related to insulin action or secretion

1999 • 52 citations

Comparison of body composition, adipocyte size, and glucose and insulin concentrations in Pima Indian and Caucasian children

1987 • 46 citations

Insulin attenuates the stimulatory effects of tumor necrosis factor α on 11β-hydroxysteroid dehydrogenase 1 in human adipose stromal cells

2000 • 44 citations

Hypothalamic-pituitary-adrenal axis and sympathetic nervous system activities in Pima Indians and Caucasians

1999 • 25 citations