Immunohistochemical Localization of Type 1 11β-Hydroxysteroid Dehydrogenase in Human Tissues1

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

1988 • 1,607 citations

LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

1988 • 1,047 citations

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

1995 • 926 citations

Does central obesity reflect “Cushing's disease of the omentum”?

1997 • 755 citations

Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme

1994 • 707 citations

Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.

1982 • 665 citations

Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium.

1989 • 623 citations

Human hypertension caused by mutations in the kidney isozyme of 11β–hydroxysteroid dehydrogenase

1995 • 621 citations

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

1991 • 434 citations

Purification and Characterization of the Corticosteroid 1lβ-Dehydrogenase Component of the Rat Liver 1lβ-Hydroxysteroid Dehydrogenase Complex*

1988 • 308 citations

11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations.

1995 • 301 citations

Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform.

1993 • 263 citations

The liver as a stem cell and lineage system

1992 • 237 citations

Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene

1996 • 235 citations

Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11β-hydroxysteroid dehydrogenase activity in man

1990 • 187 citations

Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform.

1994 • 176 citations

11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity

1996 • 172 citations

Differential Expression of 11β-Hydroxysteroid Dehydrogenase Types 1 and 2 in Human Placenta and Fetal Membranes¹

1997 • 164 citations

Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action.

1993 • 158 citations

11 beta-Hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells.

1994 • 149 citations

Several homozygous mutations in the gene for 11 beta-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess.

1995 • 138 citations

Type 2 11 beta-hydroxysteroid dehydrogenase in human fetal tissues.

1994 • 116 citations

Corticosteroid llβ-Dehydrogenase of Rat Tissues: Immunological Studies

1990 • 108 citations

Detection of human 11β-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts

1995 • 106 citations

Tissue localization of 11β-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid receptor

1992 • 104 citations

Direct inhibition of ovarian steroidogenesis by Cortisol and the modulatory role of 11β‐hydroxysteroid dehydrogenase

1993 • 102 citations

Local Active Suppression by Suppressor Cells in the Decidua: A Review

1984 • 93 citations

Differential expression of messenger ribonucleic acids encoding 11beta-hydroxysteroid dehydrogenase types 1 and 2 in human granulosa cells.

1997 • 90 citations

Immunodetection of 11β-Hydroxysteroid Dehydrogenase Type 2 in Human Mineralocorticoid Target Tissues: Evidence for Nuclear Localization*

1997 • 79 citations

Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes

1998 • 79 citations

Ovarian 11β-hydroxysteroid dehydrogenase: potential predictor of conception by in-vitro fertilisation and embryo transfer

1993 • 57 citations

11β-Hydroxysteroid dehydrogenase in the rat adrenal

1996 • 48 citations

11β-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the oocyte

1992 • 45 citations

Specificity of human 11β-hydroxysteroid dehydrogenase

1981 • 25 citations

11 beta-hydroxyandrostenedione in plasma, follicular fluid, and granulosa cells of women with normal and polycystic ovaries.

1992 • 22 citations

11β-Hydroxyandrostenedione in plasma, follicular fluid, and granulosa cells of women with normal and polycystic ovaries

1992 • 22 citations

Effect of glucocorticosteroid treatment on glucocorticoid receptor expression in human adipocytes.

1995 • 20 citations

Inhibition of aldosterone formation by cortisol in rat adrenal mitochondria

1995 • 4 citations