Structural analysis and evaluation of the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) gene in human essential hypertension

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Fetal origins of coronary heart disease

1995 • 3,440 citations

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

Molecular basis of human hypertension: Role of angiotensinogen

1992 • 1,861 citations

Fetal and placental size and risk of hypertension in adult life.

1990 • 1,737 citations

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

1988 • 1,607 citations

The investigation of linkage between a quantitative trait and a marker locus

1972 • 1,398 citations

Glucocorticoid exposure in utero: new model for adult hypertension

1993 • 873 citations

Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

1994 • 731 citations

Two stage genome–wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12

1996 • 713 citations

Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme

1994 • 707 citations

The Sensitivity of Single-Strand Conformation Polymorphism Analysis for the Detection of Single Base Substitutions

1993 • 692 citations

Initiation of hypertension in utero and its amplification throughout life.

1993 • 658 citations

Human hypertension caused by mutations in the kidney isozyme of 11β–hydroxysteroid dehydrogenase

1995 • 621 citations

Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?

1993 • 554 citations

Prenatal Exposure to Prednisone in Humans and Animals Retards Intrauterine Growth

1978 • 540 citations

A Syndrome of Apparent Mineralocorticoid Excess Associated with Defects in the Peripheral Metabolism of Cortisol*

1979 • 490 citations

Inhibition of 11β-Hydroxysteroid Dehydrogenase in Pregnant Rats and the Programming of Blood Pressure in the Offspring

1996 • 311 citations

Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform.

1993 • 263 citations

Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene

1996 • 235 citations

11β-Hydroxysteroid Dehydrogenase

1993 • 189 citations

Genetic Susceptibility for Human Familial Essential Hypertension in a Region of Homology with Blood Pressure Linkage on Rat Chromosome 10

1997 • 178 citations

Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform.

1994 • 176 citations

Gene polymorphisms of the renin-angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke

1998 • 128 citations

Gene Structure and Chromosomal Localization of the Human HSD11K Gene Encoding the Kidney (Type 2) Isozyme of 11β-Hydroxysteroid Dehydrogenase

1995 • 111 citations

Evaluation of the Angiotensinogen Locus in Human Essential Hypertension

1998 • 93 citations

Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform

1993 • 84 citations

Genetic Association of 11β-Hydroxysteroid Dehydrogenase Type 2 (HSD11B2) Flanking Microsatellites With Essential Hypertension in Blacks

1996 • 80 citations

Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform

1994 • 61 citations

Expression cloning of the aldosterone target cell-specific 11 beta-hydroxysteroid dehydrogenase from rabbit collecting duct cells.

1995 • 60 citations

A New Polymorphic Restriction Site in the Human 11β-Hydroxysteroid Dehydrogenase Type 2 Gene

1998 • 50 citations

Genetic analysis workshop II: Sib pair screening tests for linkage

1984 • 39 citations

Expression cloning of the aldosterone target cell-specific 11 beta- hydroxysteroid dehydrogenase from rabbit collecting duct cells

1995 • 23 citations

A New Polymorphic Restriction Site in the Human 11 -Hydroxysteroid Dehydrogenase Type 2 Gene

1998 • 17 citations