Peroxisome Proliferator-activated Receptor-γ Ligands Inhibit Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1999 • 1,963 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

1999 • 1,339 citations

Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

1998 • 1,138 citations

Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages

1998 • 914 citations

11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

1997 • 851 citations

Does central obesity reflect “Cushing's disease of the omentum”?

1997 • 755 citations

11β-Hydroxysteroid Dehydrogenase

1997 • 725 citations

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.

1995 • 648 citations

Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium.

1989 • 623 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

Peroxisome proliterator-activated receptors, orphans with ligands and functions

1997 • 494 citations

Differential activation of adipogenesis by multiple PPAR isoforms.

1996 • 470 citations

Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

1999 • 412 citations

A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

1998 • 407 citations

Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

2000 • 401 citations

Molecular Cloning, Expression and Characterization of Human Peroxisome Proliferator Activated Receptors γ1 and γ2

1996 • 387 citations

An Essential Regulator of Adipogenesis and Modulator of Fat Cell Function: PPARγ

1999 • 384 citations

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice.

1996 • 378 citations

Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes.

1996 • 342 citations

Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha.

1996 • 313 citations

A ROLE FOR INSULIN IN THE AETIOLOGY AND COURSE OF HYPERTENSION?

1987 • 300 citations

Visceral fat accumulation: the missing link between psychosocial factors and cardiovascular disease?

1991 • 284 citations

Effect of troglitazone on body fat distribution in type 2 diabetic patients.

1999 • 282 citations

Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation.

1995 • 268 citations

Glucocorticoids and insulin resistance: old hormones, new targets

1999 • 265 citations

Muscle and Adipose Tissue Morphology and Metabolism in Cushing’s Syndrome*

1988 • 259 citations

Functional Antagonism between CCAAT/Enhancer Binding Protein-α and Peroxisome Proliferator-activated Receptor-γ on the Leptin Promoter

1997 • 250 citations

EFFECT OF CHOLESTEROL, CHOLESTEROL ESTERS, AND NEUTRAL FATS ON FIBRINOLYSIS

1959 • 219 citations

Hypercortisolism and Obesity

1995 • 179 citations

Body fat distribution measured with CT: correlations in healthy subjects, patients with anorexia nervosa, and patients with Cushing syndrome.

1989 • 166 citations

Inhibition of Adipocyte Differentiation by HIV Protease Inhibitors

1999 • 161 citations

Glucocorticoid regulation of adipocyte differentiation: hormonal triggering of the developmental program and induction of a differentiation-dependent gene.

1985 • 139 citations

11β-hydroxysteroid dehydrogenase 1 in adipocytes: Expression is differentiation-dependent and hormonally regulated

1998 • 119 citations

Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes

1999 • 97 citations

PPARα Agonists Reduce 11β-Hydroxysteroid Dehydrogenase Type 1 in the Liver

2000 • 94 citations

Peroxisome proliferator-activated receptors A link between endocrinology and nutrition?

1993 • 80 citations

Rat PPARδ Contains a CGG Triplet Repeat and Is Prominently Expressed in the Thalamic Nuclei

1995 • 79 citations

Chromosomal Localisation, Inducibility, Tissue‐Specific Expression and Strain Differences in Three Murine Peroxisome‐Proliferator‐Activated‐Receptor Genes

1995 • 78 citations

Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y

1997 • 55 citations

Hormonal Control of Adipogenesis^a

1986 • 11 citations

Insulin Resistance in the Metabolic Syndrome

2010 • 8 citations