Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

The Ras signal transduction pathway

1994 • 345 citations

Cooperative interaction of S. pombe proteins required for mating and morphogenesis

1994 • 303 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

Two Distinct Raf Domains Mediate Interaction with Ras

1995 • 243 citations

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

1989 • 240 citations

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • 237 citations

Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cells

1985 • 226 citations

Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

1995 • 217 citations

14-3-3: Modulators of Signaling Proteins?

1994 • 206 citations

[40] Biological assays for Ras transformation

1995 • 199 citations

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.

1994 • 185 citations

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1995 • 163 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

rasH mutants deficient in GTP binding.

1986 • 107 citations

Characterization of an epithelioid cell line derived from rat small intestine: Demonstration of cytokeratin filaments

1984 • 96 citations

Pathways of Ras Function: Connections to the Actin Cytoskeleton

1993 • 64 citations

Definition of the Human raf Amino-Terminal Regulatory Region by Deletion Mutagenesis

1989 • 50 citations

ralGDS Family Members Interact with the Effector Loop of ras p21

1994 • 47 citations

Role of transforming growth factor alpha (TGF-alpha) in the transformation of ras-transfected rat intestinal epithelial cells.

1993 • 41 citations

ras^H Mutants Deficient in GTP Binding

1986 • 18 citations