Regulated Expression and RNA Processing of Transcripts from the Srp20 Splicing Factor Gene during the Cell Cycle

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Genetic variants and strains of the laboratory mouse

1990 • 1,519 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

RNA recognition: towards identifying determinants of specificity

1991 • 739 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

THE STRUCTURE AND FUNCTION OF PROTEINS INVOLVED IN MAMMALIAN PRE-mRNA SPLICING

1996 • 687 citations

RNA-binding proteins as developmental regulators.

1989 • 679 citations

Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

1979 • 677 citations

The superfamily of arginine/serine-rich splicing factors.

1995 • 671 citations

SR proteins and splicing control.

1996 • 668 citations

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

1988 • 638 citations

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

1994 • 622 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor Nocodazole

1980 • 389 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

1995 • 282 citations

Effects of Hydroxyurea and 1‐β‐D‐Arabinofuranosyl‐cytosine on Deoxyribonucleotide Pools in Mouse Embryo Cells

1971 • 280 citations

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

1994 • 267 citations

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

1990 • 253 citations

General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.

1992 • 241 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing

1991 • 224 citations

Alternative mRNA Splicing

1992 • 219 citations

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.

1996 • 200 citations

Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF.

1993 • 192 citations

The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2

1994 • 182 citations

Towards high resolution maps of the mouse and human genomes—a facility for ordering markers to 0.1 cM resolution

1994 • 161 citations

Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family.

1994 • 155 citations

A sequence compilation and comparison of exons that are alternatively spliced in neurons

1994 • 105 citations

The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2.

1992 • 90 citations

A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs

1991 • 77 citations

Molecular requirements for the mu-induced light chain gene rearrangement in pre-B cells.

1991 • 65 citations

Wild-type alternatively spliced p53: binding to DNA and interaction with the major p53 protein in vitro and in cells.

1994 • 51 citations

The heat stable antigen (mouse CD24) gene is differentially regulated but has a housekeeping promoter.

1993 • 49 citations

The Gene Encoding Human Splicing Factor 9G8

1995 • 42 citations

Conservation of histone H2A/H2B intergene regions: a role for the H2B specific element in divergent transcription

1988 • 40 citations

Stimulation of gene expression by introns: conversion of an inhibitory intron to a stimulatory intron by alteration of the splice donor sequence

1993 • 39 citations

Introns are essential for growth-regulated expression of the mouse thymidylate synthase gene.

1993 • 37 citations

RNA processing

1992 • 25 citations

A Comparison of Different Promoter, Enhancer, and Cell Type Combinations in Transient Transfections

1994 • 17 citations

T-Cell Selection: Accentuating the positive

1994 • 2 citations