Introns are essential for growth-regulated expression of the mouse thymidylate synthase gene.

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

1963 • 2,742 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

In vitro polyadenylation is stimulated by the presence of an upstream intron.

1990 • 313 citations

Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA

1990 • 312 citations

Formation of the 3′ end of U1 snRNA requires compatible snRNA promoter elements

1986 • 255 citations

3′ end formation of U1 snRNA precursors is coupled to transcription from snRNA promoters

1986 • 222 citations

Cloning and nucleotide sequencing of the bovine growth hormone gene

1982 • 214 citations

Identification of a cell-specific transcriptional enhancer in the first intron of the mouse alpha 2 (type I) collagen gene.

1987 • 169 citations

Gene expression during the mammalian cell cycle

1986 • 161 citations

Activation of an intron enhancer within the keratin 18 gene by expression of c-fos and c-jun in undifferentiated F9 embryonal carcinoma cells.

1990 • 153 citations

Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters.

1985 • 138 citations

Cell-cycle-directed regulation of thymidylate synthase messenger RNA in human diploid fibroblasts stimulated to proliferate

1986 • 126 citations

Elements required for transcription initiation of the human U2 snRNA gene coincide with elements required for snRNA 3′ end formation.

1988 • 120 citations

Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation.

1987 • 115 citations

Control of Thymidylate Synthase mRNA Content and Gene Transcription in an Overproducing Mouse Cell Line

1985 • 107 citations

Nuclear posttranscriptional processing of thymidine kinase mRNA at the onset of DNA synthesis.

1988 • 94 citations

Complex regulation of the muscle-specific contractile protein (troponin I) gene.

1987 • 88 citations

Importance of introns in the growth regulation of mRNA levels of the proliferating cell nuclear antigen gene.

1990 • 87 citations

The intron requirement for immunoglobulin gene expression is dependent upon the promoter

1988 • 87 citations

Structure of the gene for mouse thymidylate synthase. Locations of introns and multiple transcriptional start sites.

1986 • 74 citations

Introns in histone genes alter the distribution of 3′ ends

1990 • 73 citations

Functional cooperation of lens-specific and nonspecific elements in the delta 1-crystallin enhancer.

1990 • 64 citations

Control of thymidylate synthase mRNA content and gene transcription in an overproducing mouse cell line.

1985 • 63 citations

Sequence of a cDNA for mouse thymidylate synthase reveals striking similarity with the prokaryotic enzyme.

1986 • 58 citations

Thymidylate synthase gene expression is stimulated by some (but not all) introns

1989 • 48 citations

Specificity of RNA Maturation Pathways: RNAs Transcribed by RNA Polymerase III Are Not Substrates for Splicing or Polyadenylation

1987 • 46 citations

A conserved region in intron 1 negatively regulates the expression of the PCNA gene

1992 • 46 citations

G1 events and the regulation of genes for S-phase enzymes

1992 • 46 citations

Enhancement of mRNA nuclear transport by promoter elements

1987 • 44 citations

Polyadenylylation signal of the mouse thymidylate synthase gene was created by insertion of an L1 repetitive element downstream of the open reading frame.

1990 • 37 citations

Complex Regulation of the Muscle-Specific Contractile Protein (Troponin I) Gene

1987 • 36 citations

The 5'-flanking region of the mouse thymidylate synthase gene is necessary but not sufficient for normal regulation in growth-stimulated cells.

1991 • 32 citations

Ordered splicing of thymidine kinase pre-mRNA during the S phase of the cell cycle.

1990 • 31 citations

Construction and expression of mouse thymidylate synthase minigenes.

1988 • 25 citations

The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites.

1989 • 24 citations

Mouse thymidylate synthase messenger RNA lacks a 3' untranslated region.

1986 • 24 citations

Intron 1 and the 5'-flanking region of the human thymidylate synthase gene as a regulatory determinant of growth-dependent expression

1992 • 24 citations

Importance of Introns in the Growth Regulation of mRNA Levels of the Proliferating Cell Nuclear Antigen Gene

1990 • 20 citations

The 5′-Flanking Region of the Mouse Thymidylate Synthase Gene Is Necessary But Not Sufficient for Normal Regulation in Growth-Stimulated Cells

1991 • 14 citations

The Mouse Thymidylate Synthase Promoter: Essential Elements Are in Close Proximity to the Transcriptional Initiation Sites

1989 • 11 citations

Ordered Splicing of Thymidine Kinase Pre-mRNA during the S Phase of the Cell Cycle

1990 • 9 citations

Analysis of the multiple 5? and 3? termini of poly(A) + and poly(A)? deficient thymidylate synthase mRNA in growth-stimulated mouse fibroblasts

1989 • 7 citations