ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

A catalogue of splice junction sequences

1982 • 3,861 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Why genes in pieces?

1978 • 2,256 citations

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

1982 • 2,114 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

Are snRNPs involved in splicing?

1980 • 1,206 citations

Splicing of Messenger RNA Precursors

1987 • 919 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Splicing of Messenger RNA Precursors

1984 • 874 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs

1988 • 747 citations

ALTERNATIVE SPLICING: A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES

1987 • 712 citations

A trans-spliced leader sequence on actin mRNA in C. elegans

1987 • 639 citations

Speculations on RNA splicing

1981 • 639 citations

Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes

1983 • 627 citations

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

1987 • 594 citations

The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro

1983 • 593 citations

Structure of the adenovirus 2 early mRNAs

1978 • 591 citations

Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing

1986 • 568 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

1988 • 535 citations

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

1987 • 530 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing.

1986 • 517 citations

Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA

1987 • 508 citations

Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila

1988 • 495 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

1986 • 490 citations

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

1986 • 477 citations

The generality of self-splicing RNA: Relationship to nuclear mRNA splicing

1986 • 464 citations

A self-splicing RNA excises an intron lariat

1986 • 449 citations

Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å

1979 • 444 citations

Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion.

1986 • 442 citations

Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription

1988 • 425 citations

The 5′ terminus of the RNA moiety of U1 small nuclear ribonucleoprotein particles is required for the splicing of messenger RNA precursors

1984 • 404 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA

1986 • 389 citations

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.

1988 • 364 citations

Identification of a novel Y branch structure as an intermediate in trypanosome mRNA processing: Evidence for Trans splicing

1986 • 354 citations

Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.

1984 • 342 citations

Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein

1983 • 333 citations

Implications of RNA⋅RNA Splicing in Evolution of Eukaryotic Cells

1978 • 333 citations

A minimal intron length but no specific internal sequence is required for splicing the large rabbit β-globin intron

1984 • 328 citations

Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity

1988 • 324 citations

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene

1985 • 314 citations

Multiple sites of alternative splicing of the rat fibronectin gene transcript.

1987 • 299 citations

The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster

1988 • 284 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?

1988 • 280 citations

A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein

1986 • 274 citations

Alternative splicing caused by RNA secondary structure

1985 • 274 citations

An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly.

1987 • 272 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

1988 • 266 citations

Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing.

1984 • 265 citations

Messenger RNA splicing in vitro: An excised intervening sequence and a potential intermediate

1984 • 262 citations

Signals for the selection of a splice site in pre-mRNA

1987 • 247 citations

Alternative splicing generates a secreted form of N-CAM in muscle and brain

1988 • 245 citations

The structure of cat muscle pyruvate kinase.

1986 • 245 citations

Human CSF-1: gene structure and alternative splicing of mRNA precursors.

1987 • 238 citations

Base substitution in an intervening sequence of a beta+-thalassemic human globin gene.

1981 • 236 citations

Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants

1985 • 236 citations

Characterization of the branch site in lariat RNAs produced by splicing of mRNA precursors

1985 • 232 citations

The role of the mammalian branchpoint sequence in pre-mRNA splicing.

1988 • 215 citations

Trans splicing of mRNA precursors

1985 • 205 citations

U1, U2, and U4/U6 small nuclear ribonucleoproteins are required for in vitro splicing but not polyadenylation

1986 • 192 citations

The bithorax complex: control of segmental identity

1987 • 188 citations

On/off regulation of gene expression at the level of splicing

1988 • 186 citations

Role of the 3′ splice site consensus sequence in mammalian pre-mRNA splicing

1985 • 184 citations

Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing

1985 • 180 citations

Trans splicing of mrna precursors in vitro

1985 • 180 citations

Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro

1985 • 172 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

Complete nucleotide sequence of the fast skeletal troponin T gene

1986 • 146 citations

A role for exon sequences in alternative splicing of the human fibronection gene

1987 • 145 citations

T cell receptor β gene sequences in the circular DNA of thymocyte nuclei: Direct evidence for intramolecular DNA deletion in V-D-J joining

1987 • 144 citations

Early commitment of yeast pre-mRNA to the spliceosome pathway.

1988 • 143 citations

Functional Changes Associated with Structural Alterations Induced by Mobilization of a P Element Inserted in the Sex-lethal Gene of Drosophila

1987 • 143 citations

Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.

1985 • 140 citations

Evidence for in vivo trans splicing of pre-mRNAs in tobacco chloroplasts

1987 • 138 citations

Regulation of Rous sarcoma virus RNA splicing and stability.

1988 • 137 citations

Alternative RNA products from the Ultrabithorax domain of the bithorax complex.

1988 • 135 citations

Molecular cloning of a cDNA encoding the human Sm-D autoantigen.

1988 • 133 citations

Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain

1987 • 130 citations

A point mutation in the conserved hexanucleotide at a yeast 5′ splice junction uncouples recognition, cleavage, and ligation

1985 • 129 citations

Amount of RNA secondary structure required to induce an alternative splice.

1987 • 128 citations

The gene for the U6 small nuclear RNA in fission yeast has an intron

1989 • 126 citations

Cleavage of 5′ splice site and lariat formation are independent of 3′ splice site in yeast mRNA splicing

1985 • 122 citations

Evidence against a scanning model of RNA splicing.

1983 • 122 citations

Polypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing

1988 • 117 citations

Alternative splicing of tropomyosin pre-mRNAs in vitro and in vivo.

1988 • 115 citations

Regulation of messenger RNA turnover in eukaryotes

1987 • 111 citations

The thin filament of vertebrate skeletal muscle co-operatively activates as a unit

1984 • 111 citations

Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development.

1987 • 110 citations

Compilation of small RNA sequences

1994 • 109 citations

The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing.

1988 • 105 citations

Exon mutations that affect the choice of splice sites used in processing the SV40 late transcripts

1985 • 103 citations

cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains

1987 • 99 citations

Alternative processing of bovine growth hormone mRNA is influenced by downstream exon sequences.

1989 • 97 citations

Ribonucleoprotein Complex Formation During Pre-mRNA Splicing in Vitro

1986 • 93 citations

Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites

1987 • 93 citations

Role of an RNA cleavage/poly(A) addition site in the production of membrane-bound and secreted IgM mRNA.

1985 • 93 citations

RNA Splice Site Selection: Evidence for a 5′ → 3′ Scanning Model

1983 • 92 citations

Poly(A) site choice rather than splice site choice governs the regulated production of IgM heavy-chain RNAs.

1988 • 87 citations

The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA.

1987 • 84 citations

Alternative splicing of SV40 early pre-mRNA is determined by branch site selection.

1988 • 77 citations

Unusual branch point selection in processing of human growth hormone pre-mRNA.

1988 • 72 citations

A Xenopus laevis gene encodes both homeobox-containing and homeobox-less transcripts.

1987 • 63 citations

Inhibition of splicing but not cleavage at the 5' splice site by truncating human beta-globin pre-mRNA.

1986 • 58 citations

In vitro splicing of influenza viral NS1 mRNA and NS1-beta-globin chimeras: possible mechanisms for the control of viral mRNA splicing.

1986 • 56 citations

In vitro splicing of adenovirus E1A transcripts: characterization of novel reactions and of multiple branch points abnormally far from the 3′ splice site

1988 • 50 citations

A pseudo-exon in the functional humanαA-crystallin gene

1989 • 45 citations

Alternative splicing in individual aplysia neurons generates neuropeptide diversity

1987 • 45 citations

A role for ID repetitive sequences in growth- and transformation-dependent regulation of gene expression in rat fibroblasts

1987 • 44 citations

Short donor site sequences inserted within the intron of beta-globin pre-mRNA serve for splicing in vitro.

1988 • 36 citations

Role of the branch site/3'-splice site region in adenovirus-2 E1A pre-mRNA alternative splicing: evidence for 5'- and 3'-splice site co-operation

1989 • 34 citations

Cisrequirements for alternative splicing of the cardiac troponin T pre–mRNA

1988 • 25 citations

Developmental and tissue-specific expression of U4 small nuclear RNA genes.

1988 • 23 citations

Accurate 5' splice-site selection in mouse kappa immunoglobulin light chain premessenger RNAs is not cell-type-specific.

1987 • 22 citations

A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.

1986 • 13 citations