The therapeutic potential of modulating the ceramide/sphingomyelin pathway

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

2001 • 1,245 citations

How Cells Handle Cholesterol

2000 • 1,230 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Signal transduction of stress via ceramide

1998 • 687 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

2000 • 650 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

1998 • 593 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

1995 • 469 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

1997 • 440 citations

Compartmentalization of ceramide signaling: physical foundations and biological effects

2000 • 421 citations

Molecular Ordering of the Initial Signaling Events of CD95

2002 • 387 citations

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

1999 • 361 citations

Compartmentalized Production of Ceramide at the Cell Surface

1995 • 352 citations

Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death

1998 • 345 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

Ceramide Induces Bcl2 Dephosphorylation via a Mechanism Involving Mitochondrial PP2A

1999 • 340 citations

De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells

2002 • 331 citations

Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH

1998 • 313 citations

Sphingomyelin and derivatives as cellular signals

1991 • 275 citations

The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

2001 • 274 citations

A Comprehensive Study of the Radiobiological Response of the Murine (BDF1) Small Intestine

1990 • 268 citations

Ceramide-Rich Membrane Rafts Mediate CD40 Clustering

2002 • 256 citations

The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene

1998 • 240 citations

Molecular Cloning and Characterization of a Human Mitochondrial Ceramidase

2000 • 237 citations

KSR: a MAPK scaffold of the Ras pathway?

2001 • 234 citations

Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism

2000 • 219 citations

An essential role for membrane rafts in the initiation of Fas/CD95‐triggered cell death in mouse thymocytes

2002 • 219 citations

1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells.

1987 • 211 citations

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

1998 • 209 citations

Inhibition of PKB/Akt1 by C2-Ceramide Involves Activation of Ceramide-Activated Protein Phosphatase in PC12 Cells

2000 • 197 citations

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.

1996 • 193 citations

Molecular Mechanisms of Ceramide-Mediated CD95 Clustering

2001 • 191 citations

Changes in the Lipid Turnover, Composition, and Organization, as Sphingolipid-enriched Membrane Domains, in Rat Cerebellar Granule Cells Developing in Vitro

2001 • 174 citations

Association of p75 with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae

1997 • 169 citations

Ceramide binds to the CaLB domain of cytosolic phospholipase A₂and facilitates its membrane docking and arachidonic acid release

2000 • 128 citations

Ataxia Telangiectasia-mutated Gene Product Inhibits DNA Damage-induced Apoptosis via Ceramide Synthase

1999 • 120 citations

1,2-Diacylglycerols, but not phorbol esters, activate a potential inhibitory pathway for protein kinase C in GH3 pituitary cells. Evidence for involvement of a sphingomyelinase.

1988 • 120 citations

Insertional Mutagenesis of the Mouse Acid Ceramidase Gene Leads to Early Embryonic Lethality in Homozygotes and Progressive Lipid Storage Disease in Heterozygotes

2002 • 114 citations

FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression

2001 • 90 citations

Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of ras (KSR)

2002 • 89 citations

Importance of C1B Domain for Lipid Messenger-induced Targeting of Protein Kinase C

2002 • 85 citations

Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells

1989 • 81 citations

Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line

2000 • 72 citations

Inhibitory actions of ceramide upon PKC-ε/ERK interactions

2001 • 65 citations

Ceramide-Coated Balloon Catheters Limit Neointimal Hyperplasia After Stretch Injury in Carotid Arteries

2000 • 61 citations

THE 1999 MOYER AWARD Burn Injury Induces Skeletal Muscle Apoptosis and the Activation of Caspase Pathways in Rats

1999 • 51 citations