Nutritional approaches to combat oxidative stress in Alzheimer’s disease

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

1997 • 2,394 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

1997 • 2,355 citations

The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate

1993 • 2,350 citations

Pharmacology ofCurcuma longa

1991 • 1,684 citations

Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine

1993 • 1,665 citations

Flavonoids are scavengers of superoxide anions

1988 • 1,596 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Structural aspects of antioxidant activity of flavonoids

1996 • 1,317 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

1999 • 1,233 citations

Nitric Oxide Scavenging by Curcuminoids

1997 • 1,127 citations

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

2001 • 1,091 citations

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

2001 • 1,085 citations

Antioxidant potential of ferulic acid

1992 • 1,069 citations

Dietary Intake of Antioxidants and Risk of Alzheimer Disease

2002 • 1,068 citations

Berry Phenolics and Their Antioxidant Activity

2001 • 1,020 citations

Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

1999 • 983 citations

A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia

1997 • 973 citations

Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress 1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 961 citations

The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma

1987 • 889 citations

Antioxidant activity of curcumin and related compounds

1976 • 855 citations

Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress

2000 • 834 citations

Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms

2001 • 831 citations

Hydroxyl radical scavenging activity of flavonoids

1987 • 814 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

Oxidative Alterations in Alzheimer's Disease

1999 • 772 citations

Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes

1996 • 765 citations

Effect of Plant Flavonoids on Immune and Inflammatory Cell Function

1998 • 727 citations

Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity

2000 • 714 citations

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1

2002 • 700 citations

Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study

2002 • 680 citations

Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

1998 • 677 citations

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

1979 • 638 citations

Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid

1997 • 629 citations

Stress–inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

1998 • 622 citations

A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group

1997 • 612 citations

Intake of flavonoids and risk of dementia.

2000 • 611 citations

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1997 • 611 citations

Polyphenols as cancer chemopreventive agents

1995 • 603 citations

The Efficacy of Ginkgo biloba on Cognitive Function in Alzheimer Disease

1998 • 579 citations

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

2001 • 568 citations

In vivo antioxidant effect of green and black tea in man.

1996 • 562 citations

Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?

1996 • 528 citations

Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area.

1997 • 521 citations

Antimutagenic and anticarcinogenic activity of tea polyphenols

1999 • 520 citations

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl- <scp>l</scp> -carnitine and/or R -α-lipoic acid

2002 • 510 citations

Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology

2001 • 508 citations

The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective

1994 • 487 citations

Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies

2002 • 481 citations

The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

2001 • 458 citations

Inflammation and Alzheimer's disease pathogenesis

1996 • 444 citations

CURCUMIN INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION BY HUMAN PERIPHERAL BLOOD MONOCYTES AND ALVEOLAR MACROPHAGES

1999 • 443 citations

Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures

2001 • 438 citations

Actions of Carotenoids in Biological Systems

1993 • 438 citations

A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects

2001 • 438 citations

Walnut Polyphenolics Inhibit In Vitro Human Plasma and LDL Oxidation

2001 • 436 citations

Chemical and molecular regulation of enzymes that detoxify carcinogens.

1993 • 426 citations

Multiple NF-κB Enhancer Elements Regulate Cytokine Induction of the Human Inducible Nitric Oxide Synthase Gene

1998 • 408 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

Chapter 7 Protein Oxidation Processes in Aging Brain

1997 • 389 citations

Advances in Alzheimer's disease

1991 • 358 citations

β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease

1997 • 350 citations

Mechanisms of the Antioxidant Activity of a High Molecular Weight Fraction of Whey

2000 • 344 citations

Different Mechanisms of Oxidative Stress and Neurotoxicity for Alzheimer‘s Aβ(1−42) and Aβ(25−35)

2001 • 335 citations

The green tea polyphenol (−)-epigallocatechin gallate attenuates β-amyloid-induced neurotoxicity in cultured hippocampal neurons

2001 • 335 citations

Reduction of Dehydroascorbate to Ascorbate by the Selenoenzyme Thioredoxin Reductase

1997 • 331 citations

Discussion

1999 • 331 citations

Recycling of vitamin E in human low density lipoproteins.

1992 • 329 citations

Carbon Monoxide Controls the Proliferation of Hypoxic Vascular Smooth Muscle Cells

1997 • 328 citations

The “French paradox” and beyond: neuroprotective effects of polyphenols1,2 1Guest editor: Arthur Cederbaum 2This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury.” The full list of papers may be found on the homepage of the journal.

2002 • 325 citations

Apolipoprotein E Polymorphism and Alzheimer Disease

2000 • 325 citations

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention

2001 • 323 citations

Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers

2002 • 322 citations

Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals

1989 • 318 citations

Feeding acetyl- <scp>l</scp> -carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

2002 • 315 citations

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis

2001 • 309 citations

[Apolipoprotein E polymorphism and Alzheimer disease].

1996 • 302 citations

Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide‐related toxicity in cultured hippocampal neurons

2000 • 302 citations

Antioxidant potential of intermediates in phenylpropanoid metabolism in higher plants

1995 • 301 citations

Neural roles for heme oxygenase: Contrasts to nitric oxide synthase

2001 • 298 citations

Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl- <scp>l</scp> - carnitine and/or R -α-lipoic acid

2002 • 274 citations

The Lipid Peroxidation Product, 4‐Hydroxy‐2‐trans‐Nonenal, Alters the Conformation of Cortical Synaptosomal Membrane Proteins

1997 • 270 citations

Bioavailability of Ferulic Acid

1998 • 269 citations

Vitamin E and Alzheimer disease: the basis for additional clinical trials

2000 • 263 citations

Efficiency and Mechanism of the Antioxidant Action of trans-Resveratrol and Its Analogues in the Radical Liposome Oxidation

2001 • 263 citations

Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity.

2001 • 263 citations

How Curcumin Works Preferentially with Water Soluble Antioxidants

2001 • 259 citations

Inhibition of lipid peroxidation by the iron-binding protein lactoferrin

1981 • 258 citations

Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from βA(1–42) insult

2001 • 254 citations

Lipid Peroxidation and Free Radical Scavengers in Alzheimer’s Disease

1989 • 250 citations

Protective effects of the green tea polyphenol (−)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils

2000 • 247 citations

Phenolic antioxidants from herbs and spices

2000 • 247 citations

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

1999 • 245 citations

Chemical Studies on Antioxidant Mechanism of Curcuminoid: Analysis of Radical Reaction Products from Curcumin

1998 • 244 citations

Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde

2001 • 242 citations

Curcumin attenuation of acute adriamycin myocardial toxicity in rats

1998 • 239 citations

Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease

1999 • 235 citations

Free radical oxidation of brain proteins in accelerated senescence and its modulation by N -tert-butyl-α-phenylnitrone

1997 • 234 citations

Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats

2000 • 233 citations

Vitamin E Prevents Alzheimer's Amyloid ß-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production

2000 • 231 citations

Chemical Studies on Antioxidant Mechanism of Curcumin: Analysis of Oxidative Coupling Products from Curcumin and Linoleate

2001 • 229 citations

Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells

1997 • 216 citations

Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes

2001 • 213 citations

Inhibition of Peroxynitrite Dependent Tyrosine Nitration by Hydroxycinnamates

1998 • 212 citations

α-Lipoic Acid: A Metabolic Antioxidant Which Regulates NF-κB Signal Transduction and Protects Against Oxidative Injury

1998 • 205 citations

Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients

2001 • 204 citations

Plasma Concentrations of Vitamins A and E and Carotenoids in Alzheimer's Disease

1992 • 201 citations

Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester.

1993 • 201 citations

Increased lipoprotein oxidation in alzheimer’s disease

2000 • 196 citations

Inhibition of nuclear factor κB by prostaglandin A₁: An effect associated with heat shock transcription factor activation

1997 • 194 citations

Fatty Acid and Lipoic Acid Biosynthesis in Higher Plant Mitochondria

2000 • 194 citations

Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide

1996 • 189 citations

Reduction of the Ascorbyl Free Radical to Ascorbate by Thioredoxin Reductase

1998 • 186 citations

The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells

2001 • 185 citations

Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease

2001 • 184 citations

Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer's Disease

2000 • 182 citations

Polyphenolics enhance red blood cell resistance to oxidative stress: in vitro and in vivo1Mention of trade name, proprietary product, or specific equipment does not constitute a guarantee by the US Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.1

2000 • 181 citations

Plasma and Lipoprotein Levels of Tea Catechins Following Repeated Tea Consumption

1999 • 181 citations

The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands

2001 • 181 citations

The Neuroprotective Effects of Phytoestrogens on Amyloid β Protein-induced Toxicity Are Mediated by Abrogating the Activation of Caspase Cascade in Rat Cortical Neurons

2001 • 181 citations

Alpha-lipoic acid as a new treatment option for Azheimer type dementia

2001 • 179 citations

Consumption of Green Tea Causes Rapid Increase in Plasma Antioxidant Power in Humans

1999 • 178 citations

Antioxidants in Nutrition

2000 • 178 citations

Vitamin E and Neurodegenerative Disorders Associated with Oxidative Stress

2002 • 176 citations

Methionine residue 35 is important in amyloid β-peptide-associated free radical oxidative stress

1999 • 171 citations

Iron‐Catalyzed Oxidation of Menhaden Oil as Affected by Emulsifiers

1998 • 168 citations

In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain

2000 • 164 citations

Low plasma vitamin C in Alzheimer patients despite an adequate diet

1998 • 160 citations

Coronary heart disease in seven countries

1997 • 154 citations

Stress response decreases NF-kappaB nuclear translocation and increases I-kappaBalpha expression in A549 cells.

1997 • 149 citations

Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer’s amyloid β-peptide 1–42

2002 • 149 citations

Melatonin Reverses the Profibrillogenic Activity of Apolipoprotein E4 on the Alzheimer Amyloid Aβ Peptide

2001 • 145 citations

?-amyloid binds to p75NTRand activates NF?B in human neuroblastoma cells

1998 • 144 citations

Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine

2001 • 144 citations

Altered plasma antioxidant status in subjects with Alzheimer's disease and vascular dementia

1998 • 141 citations

Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence.

2000 • 141 citations

Nutrition and cognitive impairment in the elderly

2001 • 138 citations

Antioxidant Activity of Skim Milk: Effect of Heat and Resultant Sulfhydryl Groups

1980 • 138 citations

Risk factors in clinically diagnosed presenile dementia of the Alzheimer type: a case-control study in northern England.

1995 • 137 citations

Deranged Expression of Molecular Chaperones in Brains of Patients with Alzheimer's Disease

2001 • 135 citations

Neuroprotective role of curcumin fromCurcuma longa on ethanol-induced brain damage

1999 • 135 citations

Apolipoprotein E modulates Alzheimer’s Aβ(1–42)-induced oxidative damage to synaptosomes in an allele-specific manner

2002 • 134 citations

Influence of the Severity of Cognitive Impairment on the Effect of the &lt;i&gt;Ginkgo biloba&lt;/i&gt; Extract EGb 761&lt;sup&gt;®&lt;/sup&gt; in Alzheimer’s Disease

2002 • 132 citations

A preliminary study of dietary aluminium intake and risk of Alzheimer's disease

1999 • 131 citations

Influence of vitamin E and C supplementation on lipoprotein oxidation in patients with Alzheimer’s disease

2001 • 128 citations

Curcumin–glutathione interactions and the role of human glutathione S-transferase P1-1

2000 • 126 citations

Oral supplementation with whey proteins increases plasma glutathione levels of HIV‐infected patients

2001 • 126 citations

Metal-catalyzed oxidation of human serum albumin: conformational and functional changes. Implications in protein aging.

1991 • 125 citations

α-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway

2001 • 122 citations

RETRACTED: Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects

2001 • 121 citations

Diet and Parkinson's disease I

1996 • 116 citations

Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment

1997 • 113 citations

Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3α-hydroxysteroid dehydrogenase

1994 • 113 citations

Alzheimer disease: protective factors

2000 • 111 citations

Nitric oxide synthase induction in astroglial cell cultures: Effect on heat shock protein 70 synthesis and oxidant/antioxidant balance

2000 • 110 citations

Age-related increase of oxidative stress-induced apoptosis in micePrevention by Ginkgo biloba extract (EGb761)

2001 • 104 citations

Vitamin E and Other Antioxidants in Neuroprotection

1999 • 104 citations

Antioxidant Activity of an Ultrafiltration Permeate from Acid Whey

1991 • 101 citations

Vitamin Ε as an Antioxidant/Free Radical Scavenger Against Amyloid β-Peptide-Induced Oxidative Stress in Neocortical Synaptosomal Membranes and Hippocampal Neurons in Culture: Insights into Alzheimer's Disease

1999 • 101 citations

Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity.

1976 • 101 citations

Stress Proteins and SH-Groups in Oxidant-Induced Cellular Injury After Chronic Ethanol Administration in Rat

1998 • 96 citations

Role of spermine in amyloid ?-peptide-associated free radical-induced neurotoxicity

2001 • 85 citations

The influence of dietary whey protein on tissue glutathione and the diseases of aging.

1989 • 81 citations

Vitamin E for Alzheimer's disease and mild cognitive impairment

2000 • 80 citations

Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-β estradiol and induces the activity of the transcription factor NF-κB

2000 • 78 citations

Curcumin, a medicinal herbal compound capable of inducing the heat shock response

2001 • 78 citations

Vitamin E protects against Alzheimer's amyloid peptide (25–35)-induced changes in neocortical synaptosomal membrane lipid structure and composition

1998 • 78 citations

Vitamin B₁₂ levels in serum and cerebrospinal fluid of people with Alzheimer's disease

1990 • 78 citations

Preliminary Findings of High-Dose Thiamine in Dementia of Alzheimer's Type

1993 • 77 citations

Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures

1999 • 77 citations

Modifications on Antioxidant Capacity and Lipid Peroxidation in Mice under Fraxetin Treatment

1997 • 75 citations

Physico-Chemical Properties and Antioxidant Activities of Methoxy Phenols

1998 • 74 citations

A Perspective on Inflammation in Alzheimer's Disease

2000 • 73 citations

Serum levels of β‐carotene, α‐carotene and vitamin A in patients with Alzheimer's disease

1999 • 73 citations

Effect of Lactoferrin on Oxidative Stability of Corn Oil Emulsions and Liposomes

1999 • 73 citations

Protective effect of 4′, 5-dihydroxy-3′,6,7-trimethoxyflavone fromArtemisia asiaticaagainst Aβ-induced oxidative stress in PC12 cells

2001 • 73 citations

Thiamine and Alzheimer's Disease

1988 • 71 citations

Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease

1996 • 71 citations

Inhibitory effect of tea polyphenols on histamine and leukotriene B4 release from rat peritoneal exudate cells

1996 • 69 citations

The pharmacological effects of ginkgo biloba, a plant extract, on the brain of dementia patients in comparison with tacrine.

1998 • 69 citations

Purification and Characterization of a Glutathione Dependent Dehydroascorbate Reductase from Human Erythrocytes

1996 • 63 citations

A Trial of Thiamine in Alzheimer's Disease

1991 • 63 citations

Vulnerability of Synaptosomes from ApoE Knock-Out Mice to Structural and Oxidative Modifications Induced by Aβ(1−40): Implications for Alzheimer's Disease

2001 • 63 citations

Thiamine therapy in Alzheimer's disease

1996 • 61 citations

Induction of glutathione synthesis in human keratinocytes by Ginkgo biloba extract (EGb761)

2001 • 61 citations

Mechanisms of apoptosis in rat cerebellar granule cells induced by hydroxyl radicals and the effects of EGb761 and its constituents

2000 • 59 citations

Reduction of Ferrylmyoglobin by β-Lactoglobulin

1996 • 56 citations

Heat-shock protein 70 levels in brain of patients with Down Syndrome and Alzheimer’s disease

1999 • 55 citations

In vivo modulation of rodent glutathione and its role in peroxynitrite-induced neocortical synaptosomal membrane protein damage

1999 • 54 citations

Plasma and Lipoprotein Levels of Tea Catechins Following Repeated Tea Consumption

1999 • 54 citations

The effect of curcumin on glutathione-linked enzymes in K562 human leukemia cells

1999 • 49 citations

The immunoenhancing property of dietary whey protein concentrate.

1988 • 47 citations

Retinoic acid synthesis in normal and alzheimer diseased brain and human neural cells

1997 • 45 citations

The Effect of the Phenolic Antioxidant Ferulic Acid on the Oxidation of Low Density Lipoprotein Depends on the Pro-oxidant Used

1997 • 45 citations

Plasma and Red Blood Cell Thiamine Deficiency in Patients With Dementia of the Alzheimer's Type

1995 • 43 citations

Localization of a glutathione-dependent dehydroascorbate reductase within the central nervous system of the rat

1999 • 41 citations

Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements

2000 • 39 citations

Prevention of Peroxidative Stress in Rats Fed on a Low Vitamin E-containing Diet by Supplementing with a Fermented Bovine Milk Whey Preparation: Effect of Lactic Acid and β-Lactoglobulin on the Antiperoxidative Action

1998 • 38 citations

N-Acetyl-L-Cystein downregulates beta-amyloid precursor protein gene transcription in human neuroblastoma cells.

2001 • 27 citations

Immunodetection of protein composition in cerebral amyloid extracts in Alzheimer's disease: Enrichment of retinol-binding protein

1987 • 24 citations

The Aging Brain

1997 • 24 citations

Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract.

2001 • 23 citations

Vitamin E for Alzheimer's disease?

2014 • 16 citations

α-Lipoic Acid

2000 • 15 citations

LIPID PEROXIDATION AND PROTEIN OXIDATION IN ALZHEIMER'S DISEASE BRAIN: POTENTIAL CAUSES AND CONSEQUENCES INVOLVING AMYLOID -PEPTIDE-ASSOCIATED FREE RADICAL OXIDATIVE STRESS

2002 • 14 citations

Trials to slow progression and prevent disease onset

2000 • 8 citations