Stress–inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

Protein folding in the cell

1992 • 4,138 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

NF-κB: Ten Years After

1996 • 3,008 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

Heat Shock Transcription Factors: Structure and Regulation

1995 • 1,179 citations

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

1993 • 879 citations

Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.

1995 • 859 citations

Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries

1997 • 797 citations

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

1993 • 650 citations

Molecularchaperones as HSF1-specific transcriptional repressors

1998 • 623 citations

DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage.

1993 • 593 citations

Is hsp70 the cellular thermometer?

1991 • 586 citations

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.

1995 • 558 citations

The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression.

1992 • 525 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

Protein traffic on the heat shock promoter: Parking, stalling, and trucking along

1993 • 507 citations

Molecular cloning and expression of a human heat shock factor, HSF1.

1991 • 472 citations

Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle

1995 • 436 citations

Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.

1995 • 428 citations

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.

1996 • 424 citations

Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.

1992 • 417 citations

Effect of Sodium Salicylate on the Human Heat Shock Response

1992 • 411 citations

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

1988 • 407 citations

Stress-induced oligomerization and chromosomal relocalization of heat-shock factor

1991 • 391 citations

Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis

1987 • 382 citations

Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability.

1991 • 381 citations

Peroxynitrite Inhibits Glutamate Transporter Subtypes

1996 • 375 citations

Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23

1996 • 371 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

HSF4, a New Member of the Human Heat Shock Factor Family Which Lacks Properties of a Transcriptional Activator

1997 • 350 citations

Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans.

1991 • 347 citations

Stress-Inducible Cellular Responses

1995 • 337 citations

Three tomato genes code for heat stress transcription factors with a region of remarkable homology to the DNA-binding domain of the yeast HSF.

1990 • 321 citations

Repression of the Heat Shock Factor 1 Transcriptional Activation Domain Is Modulated by Constitutive Phosphorylation

1997 • 316 citations

Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor σ32

1992 • 314 citations

Activation of Heat Shock Factor 1 DNA Binding Precedes Stress-induced Serine Phosphorylation

1996 • 294 citations

Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury.

1994 • 285 citations

Activation of Heat Shock Factor 2 during Hemin-Induced Differentiation of Human Erythroleukemia Cells

1992 • 281 citations

Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects

1997 • 280 citations

18 Heat Shock Proteins and Stress Tolerance

1994 • 280 citations

Activation in vitro of sequence-specific DNA binding by a human regulatory factor

1988 • 278 citations

Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway.

1993 • 264 citations

Transcription of the human hsp70 gene is induced by serum stimulation.

1985 • 235 citations

Heat-Inducible Human Factor That Binds to a Human hsp70 Promoter

1987 • 232 citations

Activation of Drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition.

1993 • 223 citations

Negative regulation of the heat shock transcriptional response by HSBP1

1998 • 222 citations

Heat Shock Response and Protein Degradation: Regulation of HSF2 by the Ubiquitin-Proteasome Pathway

1998 • 206 citations

Inhibition of nuclear factor κB by prostaglandin A₁: An effect associated with heat shock transcription factor activation

1997 • 194 citations

Antiproliferative prostaglandins activate heat shock transcription factor.

1992 • 183 citations

Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage.

1995 • 179 citations

Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells.

1989 • 173 citations

Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.

1992 • 168 citations

HSF1 granules: a novel stress-induced nuclear compartment of human cells

1997 • 162 citations

Biochemical and clinical response of fulminant viral hepatitis to administration of prostaglandin E. A preliminary report.

1989 • 162 citations

E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex.

1989 • 147 citations

9 Properties of the Heat Shock Proteins of Escherichia coli and the Autoregulation of the Heat Shock Response

1994 • 137 citations

Function and regulation of heat shock factor 2 during mouse embryogenesis

1997 • 136 citations

HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites

1997 • 120 citations

Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance

1998 • 117 citations

The DNA-Binding Properties of Two Heat Shock Factors, HSF1 and HSF3, Are Induced in the Avian Erythroblast Cell Line HD6

1995 • 109 citations

Mouse Heat Shock Transcription Factors 1 and 2 Prefer a Trimeric Binding Site but Interact Differently with the HSP70 Heat Shock Element

1993 • 109 citations

Antiviral activity of cyclopentenone prostanoids

1997 • 109 citations

Chaperone functions of the heat shock proteins associated with steroid receptors

1994 • 108 citations

2-Cyclopenten-1-one, a New Inducer of Heat Shock Protein 70 with Antiviral Activity

1996 • 101 citations

Specific induction of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes. A new pharmacological route to stress protein expression?

1996 • 98 citations

Activation of the Heat Shock Factor 1 by Serine Protease Inhibitors

1998 • 77 citations

Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block.

1996 • 74 citations

Activation of Heat Shock Transcription Factor 3 by c-Myb in the Absence of Cellular Stress

1997 • 74 citations

Antibody-Mediated Activation of Drosophila Heat Shock Factor in Vitro

1990 • 70 citations

Biochemical and Clinical Response of Fulminant Viral Hepatitis to Administration of Prostaglandin E

1989 • 62 citations

Aspirin enhances thermotolerance in human erythroleukemic cells: an effect associated with the modulation of the heat shock response.

1995 • 60 citations

Stress-Inducible Cellular Responses

1997 • 58 citations

Molecular chaperoning of steroid hormone receptors

1996 • 58 citations

2 Cytosolic hsp70s of Saccharomyces cerevisiae : Roles in Protein Synthesis, Protein Translocation, Proteolysis, and Regulation

1994 • 54 citations

Therapeutic applications of prostaglandins

1994 • 53 citations

Heat shock proteins as immunological carriers and vaccines

1996 • 38 citations

Therapeutic applications of prostaglandins

1993 • 34 citations

7 Stress-70 Proteins and Their Interaction with Nucleotides

1994 • 32 citations

3 Chaperoning Mitochondrial Biogenesis

1994 • 29 citations

Viral infection

1996 • 13 citations