Polyphenols as cancer chemopreventive agents

Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea

1989 • 2,019 citations

Pharmacology ofCurcuma longa

1991 • 1,684 citations

Oxygen radical scavenging activity of curcumin

1990 • 1,162 citations

Tea and Cancer

1993 • 1,012 citations

Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.

1988 • 735 citations

A Study on the Fate of Curcumin in the Rat

1978 • 610 citations

Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.

1991 • 571 citations

Turmeric — chemistry, technology, and quality

1980 • 571 citations

Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.

1994 • 550 citations

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1996 • 549 citations

Absorption and tissue distribution of curcumin in rats

1980 • 439 citations

Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives.

1992 • 418 citations

Cancer chemoprevention: principles and prospects

1993 • 416 citations

Tea in chemoprevention of cancer

1996 • 388 citations

Phenolic Compounds in Food and Their Effects on Health II

1992 • 360 citations

Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants

1993 • 356 citations

Cancer‐Protective Factors in Fruits and Vegetables: Biochemical and Biological Background.

1993 • 336 citations

Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate

1995 • 330 citations

Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.

1992 • 326 citations

Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice

1992 • 299 citations

Extraction, stability, and quantitation of ellagic acid in various fruits and nuts

1989 • 284 citations

Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice.

1994 • 283 citations

Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines

1996 • 279 citations

Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene

1992 • 266 citations

Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice.

1992 • 257 citations

Metabolism of curcumn-studies with [3H]curcumin

1981 • 245 citations

Antimutagenic activity of green tea polyphenols

1989 • 238 citations

Inhibition of N-nitrosodiethylamine- and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea.

1992 • 228 citations

Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols

1991 • 224 citations

Photocarcinogenesis: Mechanisms, Models and Human Health Implications: Introduction

1996 • 222 citations

Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol.

1995 • 220 citations

Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon

1993 • 218 citations

Effect of (−)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines

1992 • 216 citations

Chemopreventive drug development: perspectives and progress.

1994 • 213 citations

Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin

1992 • 212 citations

Curcumin as an Inhibitor of Cancer

1992 • 195 citations

Inhibition of apoptosis as a mechanism of tumor promotion

1994 • 192 citations

The hamster cheek pouch carcinogenesis model

1993 • 182 citations

Protection against polycyclic aromatic hydrocarbon-induced skin tumor initiation in mice by green tea polyphenols

1989 • 180 citations

Inhibitory effect of green tea on the growth of established skin papillomas in mice.

1992 • 178 citations

Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice

1983 • 171 citations

Inhibitory Effect of (—)‐Epigallocatechin Gallate on Carcinogenesis with N‐Ethyl‐N′‐nitro‐N‐nitrosoguanidine in Mouse Duodenum

1989 • 168 citations

Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats by ellagic acid

1990 • 161 citations

Green Tea and Skin—Anticarcinogenic Effects

1994 • 158 citations

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea.

1992 • 154 citations

Detection and determination of ellagitannins

1972 • 153 citations

Anti-inflammatory activity of curcumin analogues.

1982 • 153 citations

Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach.

1995 • 149 citations

Extremely facile reaction between the ultimate carcinogen benzo[a]pyrene-7,8-diol 9,10-epoxide and ellagic acid

1982 • 148 citations

Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat

1994 • 143 citations

Inhibition of Azoxymethane‐induced Colon Carcinogenesis in Rat by Green Tea Polyphenol Fraction

1991 • 143 citations

Inhibition of the skin tumorigenicity of (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene by tannic acid, green tea polyphenols and quercetin in Sencar mice

1988 • 129 citations

Protection against N-nitrosodiethylamine and benzo[a]pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea

1993 • 127 citations

Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice.

1994 • 123 citations

Interaction of epicatechins derived from green tea with rat hepatic cytochrome P-450.

1988 • 122 citations

Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[a]anthracene

1994 • 113 citations

Inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by green and black tea

1995 • 110 citations

Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (±)-7β, 8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse

1985 • 107 citations

Hydrolyzable tannins: Potent inhibitors of hydroperoxide production and tumor promotion in mouse skin treated with 12‐O‐tetradecanoylphorbol‐13‐acetate in vivo

1992 • 107 citations

Chemopreventive Effects of Green and Black Tea on Pulmonary and Hepatic Carcinogenesis

1996 • 105 citations

Inhibitory effects of green tea infusion on in vitro invasion and in vivo metastasis of mouse lung carcinoma cells

1995 • 104 citations

A Very Low Dose of Green Tea Polyphenols in Drinking Water Prevents N‐Methyl‐N‐nitrosourea‐induced Colon Carcinogenesis in F344 Rats

1993 • 103 citations

Characterization of effective chemopreventive agents in mammary gland in vitro using an initiation-promotion protocol.

1991 • 100 citations

Two principles in endocrine therapy of cancers: hormone deprival and hormone interference.

1965 • 97 citations

Protection against 3-methylcholanthrene-induced skin tumorigenesis in Balb/C mice by ellagic acid

1984 • 92 citations

Ellagic acid binding to DNA as a possible mechanism for its antimutagenic and anticarcinogenic action

1986 • 91 citations

Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid.

1986 • 91 citations

Inhibition of tumor promoter-induced ornithine decarboxylase activity by tannic acid and other polyphenols in mouse epidermis in vivo.

1991 • 89 citations

Protection against benzo[α]pyrene- and N-nitrosodiethylamineinduced lung and forestomach tumorigenesis in A/J mice by water extracts of green tea and licorice

1992 • 86 citations

Probing the molecular program of apoptosis by cancer chemopreventive agents

1995 • 84 citations

Effects of dietary phenethyl isothiocyanate, ellagic acid, sulindac and calcium on the induction and progression of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats

1995 • 82 citations

Experimental studies of the inhibitory effects of green tea catechin on mice large intestinal cancers induced by 1,2-dimethylhydrazine

1994 • 80 citations

Effect of ellagic acid on hepatic and pulmonary xenobiotic metabolism in mice: studies on the mechanism of its anticarcinogenic action

1985 • 77 citations

Effect of turmeric and curcumin on BP-DNA adducts

1993 • 77 citations

Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice

1991 • 75 citations

STUDIES ON THE PATHOGENESIS OF THROMBOSIS: AN EXPERIMENTAL "HYPERCOAGULABLE" STATE INDUCED BY THE INTRAVENOUS INJECTION OF ELLAGIC ACID.

1964 • 73 citations

The effects of Chinese tea on the occurrence of esophageal tumors induced by N-nitrosomethylbenzylamine in rats

1992 • 69 citations

Protective effects of green tea polyphenols administered by oral intubation against chemical carcinogen-induced forestomach and pulmonary neoplasia in A/J mice

1993 • 66 citations

Inhibition of aflatoxin B₁ mutagenesis in Salmonella typhimurium and DNA damage in cultured rat and human tracheobronchial tissues by ellagic acid

1987 • 66 citations

Inhibitory Effect of Ellagic Acid on N‐2‐Fluorenylacetamide‐induced Liver Carcinogenesis in Male ACI/N Rats

1988 • 64 citations

Ellagic acid: a potent naturally occurring inhibitor of benzo[a]pyrene metabolism and its subsequent glucuronidation, sulfation and covalent binding to DNA in cultured BALB/C mouse keratinocytes

1984 • 64 citations

Protection against malignant conversion of chemically induced benign skin papillomas to squamous cell carcinomas in SENCAR mice by a polyphenolic fraction isolated from green tea.

1993 • 64 citations

Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage

1988 • 61 citations

Biodistribution of ellagic acid and dose‐related inhibition of lung tumorigenesis in A/J mice

1992 • 59 citations

The effects of ellagic acid and 13-cis-retinoic acid on N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats

1991 • 57 citations

Inhibitory Effects of Tea Catechins, Black Tea Extract and Oolong Tea Extract on Hepatocarcinogenesis in Rat

1996 • 57 citations

Antitumor-Promoting Activities of Tannic Acid, Ellagic Acid, and Several Gallic Acid Derivatives in Mouse Skin

1992 • 56 citations

Inhibition of N-nitrosobenzylmethylamine metabolism and DNAbinding in cultured rat esophagus by ellagic acid

1988 • 56 citations

Inhibition of oncogene expression by green tea and (‐)‐epigallocatechin gallate in mice

1995 • 55 citations

Strategies for identification and clinical evaluation of promising chemopreventive agents.

1996 • 55 citations

Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products

1994 • 50 citations

Inhibition of benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol metabolism and DNA binding in mouse lung explants by ellagic acid.

1985 • 49 citations

Protection against 12-O-tetradecanoylphorbol-13-acetate-caused inflammation in SENCAR mouse ear skin by polyphenolic fraction isolated from green tea

1993 • 44 citations

Selective inhibition of methylbenzylnitrosamine-induced formation of esophageal O6-methylguanine by dietary ellagic acid in rats.

1988 • 41 citations

Promoting apoptosis

1995 • 40 citations

The effect of ellagic acid on the uptake, persistence, metabolism and DNA-binding of benzo[a]pyrene in cultured explants of strain A/J mouse lung

1985 • 37 citations

Chemoprevention of Cancer

1991 • 30 citations

The effect of Chinese tea on the occurrence of esophageal tumors induced by N-nitrosomethylbenzylamine formed in vivo.

1990 • 28 citations

Distribution and metabolism of ellagic acid in the mouse following intraperitoneal administration

1987 • 24 citations

Effect of ellagic acid and 3-O-decylellagic acid on the formation of benzo[a]pyrene-derived DNA adducts in vivo and on the tumorigenicity of 3-methylcholanthrene in mice

1986 • 24 citations

Ellagic acid effects on the carcinogenicity, DNA-binding and metabolism of 7,12-dimethylbenz(a)anthracene (DMBA).

1989 • 20 citations

Inhibitory Effects of Curcumin on Carcinogenesis in Mouse Epidermis

1992 • 20 citations

Re-evaluation of the effect of ellagic acid on dimethylnitrosamine mutagenicity

1989 • 17 citations