α-Lipoic Acid: A Metabolic Antioxidant Which Regulates NF-κB Signal Transduction and Protects Against Oxidative Injury

Arzneimittelforschung

2005 • 8,820 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Strategies of antioxidant defense

1993 • 1,963 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro

1981 • 1,071 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Pharmacology of Cerebral Ischemia

1989 • 675 citations

Multienzyme complexes

1974 • 655 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca²⁺ and Na⁺: Implications for Neurodegeneration

1994 • 492 citations

Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase

1992 • 363 citations

Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling

1990 • 358 citations

Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients

1989 • 349 citations

Glutathione monoethyl ester: Preparation, uptake by tissues, and conversion to glutathione

1985 • 349 citations

Crystalline α-Lipoic Acid: A Catalytic Agent Associated with Pyruvate Dehydrogenase

1951 • 335 citations

Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization

1997 • 332 citations

Recycling of vitamin E in human low density lipoproteins.

1992 • 329 citations

Involvement of Free Radicals in Excitotoxicity In Vivo

1995 • 325 citations

Lipoic and Dihydrolipoic Acids as Antioxidants. a Critical Evaluation

1994 • 301 citations

Alternative Mechanisms for Activation of Human Immunodeficiency Virus Enhancer in T Cells

1988 • 265 citations

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

1993 • 260 citations

The Standard Redox Potential of Cysteine-Cystine from the Thiol-Disulphide Exchange Reaction with Glutathione and Lipoic Acid

1967 • 254 citations

HIV-induced cysteine deficiency and T-cell dysfunction — a rationale for treatment with N-acetylcysteine

1992 • 254 citations

Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?

1995 • 243 citations

Inhibition of NF-κB Activation by Vitamin E Derivatives

1993 • 243 citations

Thioctic Acid and Dihydrolipoic Acid are Novel Antioxidants Which Interact With Reactive Oxygen Species

1991 • 239 citations

Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes.

1993 • 238 citations

Glutamate Receptor Agonists Stimulate Nitric Oxide Synthase in Primary Cultures of Cerebellar Granule Cells

1992 • 234 citations

α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells

1992 • 232 citations

Exercise-induced oxidative stress: glutathione supplementation and deficiency

1994 • 226 citations

Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation

1988 • 215 citations

Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes

1994 • 211 citations

Vitamin E recycling in human erythrocyte membranes

1993 • 204 citations

Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization.

1992 • 204 citations

Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo.

1992 • 185 citations

Purification and Properties of Glutathione Reductase of Human Erythrocytes

1963 • 181 citations

α-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats

1996 • 179 citations

The relationship between excitotoxicity and oxidative stress in the central nervous system

1993 • 167 citations

Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol

1989 • 166 citations

Induction of cystine transport activity in mouse peritoneal macrophages.

1987 • 163 citations

α-Lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium

1994 • 146 citations

NITRIC OXIDE: ROLE IN NEUROTOXICITY

1995 • 137 citations

Near-Total Glutathione Depletion and Age-Specific Cataracts Induced by Buthionine Sulfoximine in Mice

1986 • 115 citations

Scavenging of hypochlorous acid by lipoic acid

1991 • 112 citations

α-Lipoic Acid Supplementation Prevents Symptoms of Vitamin E Deficiency

1994 • 106 citations

α-Lipoic Acid Increases Intracellular Glutathione in a Human T-Lymphocyte Jurkat Cell Line

1995 • 105 citations

Involvement of intracellular Ca²⁺ in oxidant‐induced NF‐κB activation

1996 • 105 citations

Growth factors for bacteria

1937 • 100 citations

The Free Radical Scavenger, α-Lipoic Acid, Protects Against Cerebral Ischemia-Reperfusion Injury in Gerbils

1995 • 96 citations

α-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats

1995 • 93 citations

Glutathione Reductase and Lipoamide Dehydrogenase Have Opposite Stereospecificities for α-Lipoic Acid Enantiomers

1995 • 93 citations

A mouse model of focal cerebral ischemia for screening neuroprotective drug effects

1992 • 91 citations

S-nitrosothiols and nitric oxide, but not sodium nitroprusside, protect nigrostriatal dopamine neurons against iron-induced oxidative stress in vivo

1996 • 91 citations

Abnormal Amino-Acid Concentrations in the Blood of Patients with Acquired Immunodeficiency Syndrome (AIDS) May Contribute to the Immunological Defect

1988 • 90 citations

The potent free radical scavenger α-lipoic acid improves memory in aged mice: Putative relationship to NMDA receptor deficits

1993 • 89 citations

α-Ketoglutaric Dehydrogenase

1960 • 86 citations

Prolonged Pretreatment with α-Lipoic Acid Protects Cultured Neurons against Hypoxic, Glutamate-, or Iron-Induced Injury

1995 • 84 citations

The metabolism of dl-[1, 6-14C]lipoic acid in the rat

1974 • 80 citations

[32] Biosynthesis of lipoic acid via unsaturated fatty acids

1979 • 77 citations

Prevention of singlet oxygen-induced DNA damage by lipoate

1993 • 75 citations

Vitamin E and alpha-lipoate: Role in antioxidant recycling and activation of the NF-κB transcription factor

1993 • 74 citations

Elucidation of Antioxidant Activity of α-Lipoic Acid Toward Hydroxyl Radical

1995 • 73 citations

Dihydrolipoate Reduces Neuronal Injury after Cerebral Ischemia

1992 • 73 citations

Antioxidant Activities of Dihydrolipoic Acid and its Structural Homologues

1993 • 73 citations

Stability and structure of binary and ternary complexes of α-lipoate and lipoate derivatives with Mn2+, Cu2+, and Zn2+ in solution

1978 • 71 citations

Reduction and transport of lipoic acid by human erythrocytes

1995 • 69 citations

Effect of α-lipoic acid on vitamin C and vitamin E deficiencies

1959 • 67 citations

Studies on the efficacy of lipoate and dihydrolipoate in the alteration of cadmium2+ toxicity in isolated hepatocytes

1990 • 65 citations

The endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum

1994 • 64 citations

Stable isotope studies on the biosynthesis of lipoic acid in Escherichia coli

1980 • 63 citations

Inhibition of NF-κB Activation in Human T-Cell Lines by Anetholdithiolthione

1996 • 61 citations

Hepatic lipoate uptake

1989 • 56 citations

Allosteric modulation of the NMDA receptor by dihydrolipoic and lipoic acid in rat cortical neurons in vitro

1993 • 52 citations

Oxidation of .alpha.-lipoic acid

1975 • 51 citations

Dihydrolipoic acid activates oligomycin-sensitive thiol groups and increases ATP synthesis in mitochondria

1991 • 49 citations

Effect of lipoic acid on redox state of coenzyme Q in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and diethyldithiocarbamate

1994 • 48 citations

Mode of Action of Hypoglycemic Agents

1970 • 43 citations

Biological oxidants and antioxidants

1995 • 41 citations

The nutritional role of acetate for lactic acid bacteria; the response to substances related to acetate.

1946 • 40 citations

Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E Free Radical Reductase

1990 • 35 citations

Accessory factor requirement for pyruvate oxidation.

1947 • 32 citations

Change in α‐ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH

1990 • 28 citations

The Potent Free Radical Scavenger α‐Lipoic Acid Improves Cognition in Rodents

1994 • 28 citations

Reevaluation of Superoxide Scavenging Activity of Dihydrolipoic Acid and Its Analogues by Chemiluminescent Method Using 2-Methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo-[1,2-a]pyrazine-3-one (MCLA ) as a Superoxide Probe

1996 • 24 citations

On the probable identity of several unidentified growth factors.

1949 • 24 citations

Biosynthesis of lipoic acid in the rat: Incorporation of 35S- and 14C-labeled precursors

1980 • 23 citations

[45] Determination of structure-antioxidant activity relationships of dihydrolipoic acid

1994 • 23 citations

THE PHOTOPEROXIDATION OF UNSATURATED ORGANIC MOLECULES—IX. LIPOIC ACID INHIBITION OF RUBRENE AUTOPEROXIDATION

1974 • 20 citations

Observations on an unknown growth factor essential for Tetrahymena geleii.

1949 • 19 citations

Elucidation of antioxidant activity of dihydrolipoic acid toward hydroxyl radical using a novel hydroxyl radical generator NP-III.

1995 • 13 citations

Studies on lipoic acid uptake by bacteria

1964 • 13 citations

The evolution of antioxidants in modern medicine. Herausgegeben von K. Schmidt, A. Diplock und H. Ulrich. 80 Seiten, zahlr. Abbildungen und Tabellen. Hippokrates Verlag, Stuttgart 1994. Preis: 58,00 DM

1995 • 1 citations