The TGF-β family and its composite receptors

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Negative regulation of transforming growth factor-β by the proteoglycan decorin

1990 • 1,490 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Isolation of the bovine and human genes for müllerian inhibiting substance and expression of the human gene in animal cells

1986 • 997 citations

α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice

1992 • 887 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

Activin-Binding Protein from Rat Ovary Is Follistatin

1990 • 886 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Receptors for the TGF-β family

1992 • 638 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β

1993 • 578 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1992 • 538 citations

A structural superfamily of growth factors containing a cystine knot motif

1993 • 529 citations

Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

1992 • 495 citations

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

1992 • 483 citations

decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo

1992 • 480 citations

Crystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the Superfamily

1992 • 446 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Processed Vg1 protein is an axial mesoderm inducer in xenopus

1993 • 417 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

1994 • 379 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

An unusual feature revealed by the crystal structure at 2.2 Å resolution of human transforming growth fact or-β2

1992 • 337 citations

Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member

1993 • 320 citations

GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines.

1993 • 318 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct

1994 • 290 citations

The BMP proteins in bone formation and repair

1992 • 273 citations

Determination of Type I Receptor Specificity by the Type II Receptors for TGF-β or Activin

1993 • 261 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

Cloning of a Second Type of Activin Receptor and Functional Characterization in Xenopus Embryos

1992 • 226 citations

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

1993 • 224 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand.

1993 • 181 citations

Bone morphogenetic protein 4 (BMP-4), a member of the TGF-β family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity

1991 • 167 citations

The DVR gene family in embryonic development

1991 • 159 citations

Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.

1994 • 153 citations

Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region.

1993 • 122 citations