Bone morphogenetic proteins: An unconventional approach to isolation of first mammalian morphogens

Bone: Formation by Autoinduction

1965 • 5,498 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Hox genes in vertebrate development

1994 • 2,057 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

Extracellular matrix biochemistry

1984 • 1,038 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats

1972 • 815 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)

1990 • 616 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinase

1996 • 513 citations

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

1995 • 510 citations

Cell Biology and Biochemistry of Endochondral Bone Development

1981 • 487 citations

Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm

1992 • 486 citations

Inhibition of activin receptor signaling promotes neuralization in Xenopus

1994 • 484 citations

Evidence from normal expression and targeted misexpression that Bone Morphogenetic Protein-4 (Bmp-4) plays a role in mouse embryonic lung morphogenesis

1996 • 480 citations

Conserved left–right asymmetry of nodal expression and alterations in murine situs inversus

1996 • 459 citations

A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3

1996 • 443 citations

Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos

1996 • 436 citations

A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin

1995 • 436 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development

1995 • 424 citations

Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development.

1994 • 415 citations

Purification and Partial Amino Acid Sequence of Osteogenin, a Protein Initiating Bone Differentiation

1989 • 405 citations

The enamel knot as a signaling center in the developing mouse tooth

1996 • 393 citations

Bone and cartilage differentiation

1994 • 389 citations

Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells

1994 • 368 citations

Transforming growth factor β type 1 binds to collagen IV of basement membrane matrix: Implications for development

1991 • 350 citations

Mechanisms of organogenetic tissue interaction.

1967 • 343 citations

Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5

1996 • 336 citations

Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix.

1983 • 318 citations

Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.

1996 • 301 citations

Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb

1996 • 265 citations

Regulatory Role of Transforming Growth Factor-β, Bone Morphogenetic Protein-2, and Protein-4 on Gene Expression of Extracellular Matrix Proteins and Differentiation of Dental Pulp Cells

1994 • 254 citations

Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression.

1992 • 240 citations

Boundaries and fields in early embryos

1992 • 239 citations

Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors

1995 • 238 citations

Bone morphogenetic protein receptors

1996 • 223 citations

The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.

1996 • 216 citations

Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor ?1 and ?2*1

1991 • 205 citations

Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: Regulation by discrete domains of laminin

1990 • 198 citations

Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7).

1996 • 189 citations

Peptide Growth Factors and Their Receptors I

1990 • 187 citations

ON THE HEALING OF ASEPTIC BONE CAVITIES BY IMPLANTATION OF ANTISEPTIC DECALCIFIED BONE

1889 • 185 citations

Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen.

1990 • 176 citations

Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation.

1995 • 176 citations

Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development

1996 • 164 citations

Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen.

1992 • 162 citations

Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4

1996 • 159 citations

Natural bovine osteogenin and recombinant human bone morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant cultures.

1992 • 156 citations

Topological similarities in TGF-β2, PDGF-BB and NGF define a superfamily of polypeptide growth factors

1993 • 155 citations

Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions.

1996 • 141 citations

Follistatins: More than follicle-stimulating hormone suppressing proteins

1993 • 131 citations

Bone Morphogenetic Protein-2 (BMP-2) Inhibits Muscle Development and Promotes Cartilage Formation in Chick Limb Bud Cultures

1996 • 116 citations

Osteogenin (bone morphogenetic protein-3) stimulates cartilage formation by chick limb bud cells in vitro

1991 • 105 citations

Recent Investigations on the Growth of Bone

1945 • 93 citations

Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells.

1995 • 81 citations

Collagenous bone matrix is a local mitogen

1979 • 76 citations

Stimulation of Proteoglycan Synthesis in Explants of Porcine Articular Cartilage by Recombinant Osteogenic Protein-1 (Bone Morphogenetic Protein-7)*

1997 • 71 citations

Refined Crystal Structure of Human Transforming Growth Factor β2 at 1·5 Å Resolution

1993 • 62 citations

Osteogenic Protein-1 Is Required for Mammalian Eye Development

1996 • 49 citations