Aneuploidy, the somatic mutation that makes cancer a species of its own

The Hallmarks of Cancer

2000 • 27,569 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Molecular Biology of the Cell

2017 • 5,885 citations

Molecular Cell Biology

1986 • 5,808 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

1973 • 2,275 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Molecular Biology of the Gene

1970 • 2,116 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

The chromosomes in human cancer and leukemia

1990 • 1,780 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis

1954 • 1,475 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

The age distribution of cancer and a multi-stage theory of carcinogenesis

2004 • 1,306 citations

Modes of Speciation.

1978 • 1,300 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

Understanding the control of metabolism

1997 • 1,265 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Gene Expression Profiles in Normal and Cancer Cells

1997 • 1,157 citations

Molecular Cell Biology

2002 • 1,145 citations

THE MOLECULAR BASIS OF DOMINANCE

1981 • 1,033 citations

Artificial transmutation of the gene

1996 • 966 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 796 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1992 • 784 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

1997 • 718 citations

Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

1964 • 687 citations

Clonal origin of human tumors

1976 • 662 citations

Polyploidy in angiosperms

1997 • 624 citations

SEGMENTAL ANEUPLOIDY AND THE GENETIC GROSS STRUCTURE OF THE DROSOPHILA GENOME

1972 • 609 citations

Transmission of chromosomal instability after plutonium α-particle irradiation

1992 • 603 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

Centrosome defects and genetic instability in malignant tumors.

1998 • 583 citations

DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis

1992 • 554 citations

Molecular cell biology 3.0

1996 • 528 citations

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

1998 • 515 citations

On the nature of hereditable variation in cultured somatic cells

1976 • 497 citations

Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals

1995 • 481 citations

Radiation carcinogenesis

2000 • 466 citations

The Presence of Typical and Atypical BCR-ABL Fusion Genes in Leukocytes of Normal Individuals: Biologic Significance and Implications for the Assessment of Minimal Residual Disease

1998 • 457 citations

Rous Sarcoma Virus: a Function required for the Maintenance of the Transformed State

1970 • 444 citations

Chromosomes and Cancer.

1975 • 437 citations

Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells

1999 • 436 citations

Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms.

1997 • 434 citations

Chemical and physical carcinogenesis: advances and perspectives for the 1990s.

1991 • 433 citations

Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung

1890 • 398 citations

The Promise of Comparative Genomics in Mammals

2001 • 387 citations

Human Genetics

1986 • 381 citations

Genetic instability of cancer cells is proportional to their degree of aneuploidy

1998 • 378 citations

Molecular biology of the gene

1988 • 332 citations

Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity?

1984 • 322 citations

The Consequences of Chromosome Imbalance

1986 • 314 citations

Enemies within: the genesis of retrovirus oncogenes

1981 • 303 citations

The Molecular Biology of Cancer

1974 • 298 citations

Mutagenesis by chemical agents in V79 Chinese hamster cells: A review and analysis of the literature

1981 • 297 citations

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.

1994 • 295 citations

Crafting science: a sociohistory of the quest for the genetics of cancer

1997 • 283 citations

Down syndrome—a disruption of homeostasis

1983 • 280 citations

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

2000 • 274 citations

Das Krebsproblem

1963 • 266 citations

HUMAN TUMOR SUPPRESSOR GENES

1990 • 266 citations

Unexpected Sensitivity to the Induction of Mutations by Very Low Doses of Alpha-Particle Radiation: Evidence for a Bystander Effect

1999 • 265 citations

Crafting Science

1996 • 263 citations

Differences between the Ribonucleic Acids of Transforming and Nontransforming Avian Tumor Viruses

1970 • 262 citations

Chemically induced aneuploidy in mammalian cells: Mechanisms and biological significance in cancer

1986 • 260 citations

Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy

2000 • 253 citations

Oncogene-induced liver neoplasia in transgenic mice.

1989 • 249 citations

Chronic Myelogenous Leukemia — New Concepts

1981 • 245 citations

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice

1995 • 224 citations

ROLE OF CHROMOSOMES IN CANCEROGENESIS, AS STUDIED IN SERIAL TISSUE CULTURE OF MAMMALIAN CELLS

1958 • 220 citations

The genetics of Drosophila

1988 • 218 citations

Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target.

1996 • 217 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

Rate of Somatic Mutation in Immunoglobulin Production by Mouse Myeloma Cells

1971 • 213 citations

An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.

1984 • 210 citations

Aneuploidy: Etiology and mechanisms

1987 • 204 citations

Chromosome abnormalities in human reproductive wastage

1986 • 202 citations

Aneuploidy and ageing: chromosome studies on a random sample of the population using G-banding

1978 • 197 citations

Molecular Biology of RNA Tumor Viruses

1980 • 194 citations

ANEUPLOIDY IN THE DEGENERATIVE PHASE OF SERIAL CULTIVATION OF HUMAN CELL STRAINS

1963 • 193 citations

Dominant effects of tubulin overexpression in Saccharomyces cerevisiae.

1989 • 191 citations

Clonal Origin of Human Tumors

1979 • 185 citations

Foundations of experimental embryology

1964 • 183 citations

Fundamentals of oncology

1981 • 180 citations

Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells

1997 • 178 citations

An Experimental Study of the Initiating Stage of Carcinogenesis, and a Re-examination of the Somatic Cell Mutation Theory of Cancer

1949 • 176 citations

The chromosomes in ontogeny and oncogeny.

1961 • 175 citations

Primary vs. secondary neoplasia-associated chromosomal abnormalities—balanced rearrangements vs. genomic imbalances?

1996 • 175 citations

Retroviruses as carcinogens and pathogens: expectations and reality.

1987 • 173 citations

Cancer: Science and Society.

1979 • 173 citations

The Cellular Basis of Tumor Progression

1997 • 163 citations

Cancer a Comprehensive Treatise 2

1975 • 160 citations

High levels of chromosome instability in polyploids of Saccharomyces cerevisiae

1990 • 160 citations

Supernumerary centrosomes and cancer: Boveri's hypothesis resurrected

1998 • 156 citations

The origin of point mutations in human tumor cells.

1992 • 154 citations

Rapid structural and epigenetic changes in polyploid and aneuploid genomes

1999 • 151 citations

Aneuploidy: a report of an ECETOC task force

1998 • 150 citations

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

1994 • 141 citations

Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate

2000 • 139 citations

How aneuploidy may cause cancer and genetic instability.

2000 • 137 citations

How aneuploidy affects metabolic control and causes cancer

1999 • 137 citations

Genetic Heterogeneity of the c-K-ras Locus in Colorectal Adenomas but not in Adenocarcinomas

1993 • 136 citations

Tumor initiation and promotion.

1978 • 135 citations

The significance of mutation in relation to the origin of tumors: a review.

1955 • 129 citations

Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality

1998 • 128 citations

Zytologische Untersuchungen �ber die Natur maligner Tumoren

1930 • 126 citations

A bcr-v-abl oncogene induces lymphomas in transgenic mice.

1989 • 125 citations

Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice.

1995 • 125 citations

Aneuploidy Precedes and Segregates with Chemical Carcinogenesis

2000 • 123 citations

Chromosome error propagation and cancer

1989 • 114 citations

Spontaneous neoplastic evolution of Chinese hamster cells in culture: multistep progression of karyotype.

1983 • 111 citations

Cancer: the rise of the genetic paradigm

1995 • 109 citations

Isolation and characterization of thymidine transport mutants of Chinese hamster cells

1969 • 108 citations

Speculations on the roles of RB1 in tissue‐specific differentiation, tumor initiation, and tumor progression

1993 • 107 citations

A model of DNA aneuploidization and evolution in colorectal cancer.

1994 • 105 citations

Intratumor cellular heterogeneity and alterations in ras oncogene and p53 tumor suppressor gene in human prostate carcinoma.

1995 • 105 citations

Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells a correlation with different ethylation products in DNA

1984 • 105 citations

Karyotypic progression in human tumors

1983 • 104 citations

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.

1993 • 104 citations

Mutationstheorie der Geschwulst-Entstehung

1928 • 102 citations

Avian Tumor Virus RNA: A Comparison of Three Sarcoma Viruses and Their Transformation-Defective Derivatives by Oligonucleotide Fingerprinting and DNA-RNA Hybridization

1973 • 101 citations

American Type Culture Collection catalogue of cell lines and hybridomas

1988 • 101 citations

Expression of cloned sequences in biopsies of human colonic tissue and in colonic carcinoma cells induced to differentiate in vitro.

1987 • 101 citations

The detection and assessment of the aneugenic potential environmental chemicals: the European Community Aneuploidy Project

1993 • 100 citations

Advances in Human Genetics 9

1979 • 100 citations

Toxic Effects of Excess Cloned Centromeres

1986 • 96 citations

Nonrandom chromosomal changes in untreated retinoblastomas

1983 • 93 citations

Activation of cellular genes by avian RNA tumor viruses.

1980 • 91 citations

The Impact of Aneuploidy Upon Public Health: Mortality and Morbidity Associated with Human Chromosome Abnormalities

1985 • 91 citations

The promise of cancer genetics

1998 • 90 citations

Aneuploidy, an early event in mouse skin tumor development

1986 • 85 citations

Chemical carcinogenesis: mechanisms and approaches to its control.

1971 • 82 citations

The detection and evaluation of aneugenic chemicals

1996 • 81 citations

Patterns of genomic imbalances in human solid tumors (Review).

2000 • 80 citations

Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens

1995 • 80 citations

How aneuploidy affects metabolic control and causes cancer

1999 • 79 citations

Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells.

1996 • 78 citations

Fundamentals of Oncology

1986 • 77 citations

The effects of chemotherapy on the kinetics of leukemic cell behavior.

1965 • 76 citations

Surmise and Fact on the Nature of Cancer

1959 • 76 citations

Relationship between chromosomal instability and intratumoral regional DNA ploidy heterogeneity in primary gastric cancers.

2000 • 75 citations

Characteristics of “Hybrid”-Type Clonal Cell Lines Obtained From Mixed Cultures <italic>In Vitro</italic><xref ref-type="fn" rid="fn1">2</xref>

1962 • 74 citations

Mechanistic aspects on chemical induction of spindle disturbances and abnormal chromosome numbers

1986 • 71 citations

Chemical Probes and Possible Targets for the Induction of Aneuploidy

1985 • 71 citations

Multiple etiologic factors in neoplastic development.

1965 • 70 citations

Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy.

1996 • 69 citations

Chemically induced aneuploidy in mammalian cells in culture

1986 • 66 citations

Toxic effects of excess cloned centromeres.

1986 • 66 citations

The Molecular Biology of RNA Tumor Viruses

1975 • 64 citations

Chronic Myelogenous Leukemia — New Concepts

1981 • 63 citations

The relationship of DNA ploidy to chromosomal instability in primary human colorectal cancers.

1999 • 63 citations

The cells of the body: a history of somatic cell genetics

1996 • 63 citations

R�ntgenausl�sung von Chromosomenmutationen bei Drosophila melanogaster. I

1939 • 63 citations

Catalogue of Chromosome Aberrations in Cancer

1983 • 61 citations

Radiation Oncogenesis in Cell Culture

1982 • 61 citations

Cytogenetically marked clones in human fibroblasts cultured from normal subjects

1976 • 60 citations

The Genetics of Cancer*

1933 • 60 citations

The Chromosomes of the Vertebrates

1951 • 54 citations

p53 gene mutations are not required for early dissemination of cancer cells

1999 • 52 citations

Neoplasia and Cytogenetic Abnormalities

1985 • 51 citations

The Cancer Problem: A Critical Analysis and Modern Synthesis

1969 • 51 citations

Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers

1997 • 51 citations

CANCER BIOLOGY: COMPARATIVE and GENETIC*

1956 • 50 citations

Aneuploidy in mammalian somatic cells in vivo

1986 • 50 citations

The Challenge to Man of the Neoplastic Cell

1967 • 50 citations

A view of the relation between carcinogenesis and mutagenesis

1989 • 45 citations

Genetic mechanisms in carcinogenesis and tumor progression

1989 • 45 citations

Sarcomas routinely produced from putatively nontumorigenic Balb/3T3 and C3H/10T1/2 cells by subcutaneous inoculation attached to plastic platelets

1976 • 44 citations

Cytochemical differences between mammalian cell lines of normal and neoplastic origins

1963 • 44 citations

Die Mutationstheorie der Geschwulstentstehung

1963 • 42 citations

Latent Viruses and Mutated Oncogenes: No Evidence for Pathogenicity

1992 • 41 citations

Are human cancers ever diploid—or often trisomic? Conflicting evidence from direct preparations and cultures

1990 • 39 citations

Chromosomal characteristics of chronic and blastic phases of Ph-positive chronic myeloid leukemia

1985 • 39 citations

Mutagenesis to aminopterin resistance in cultured hamster cells

1971 • 38 citations

Annotation: genetic effects of aneuploidy.

1973 • 38 citations

Neoplastic Transformation in Human Cell Culture

1991 • 37 citations

Chromosomal Variation and the Origin of Drug-Resistant Mutants in Mammalian Cell Lines

1974 • 37 citations

Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79

1997 • 36 citations

R�ntgenausl�sung von Chromosomenmutationen bei Drosophila melanogaster II

1941 • 35 citations

Karyotype evolution and tumor development

1983 • 34 citations

Genetics of mammalian cell cultures

1966 • 32 citations

Therapeutic and prognostic value of initial chromosomal findings at the blastic phase of Ph1-positive chronic myeloid leukemia

1983 • 32 citations

Induction of cytogenetic effects in human fibroblast cultures after exposure to formaldehyde or X-rays

1983 • 30 citations

The secrets of cancer

1982 • 30 citations

Contributions to the genetics of Drosophila melanogaster ...

1919 • 29 citations

Molecular cytogenetics of multiple drug resistance

1993 • 28 citations

Effects of benzo[a]pyrene and (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501A1 or 1A2

1993 • 26 citations

Chromosomes and Neoplasia

1979 • 25 citations

On the Elimination of the X-Chromosome from the Egg of Drosophila melanogaster by X-rays

1921 • 25 citations

Die Veränderungen der Häufigkeit euploider und aneuploider Chromosomenzahlen in der hepatektomierten Rattenleber bei Buttergelb-Verfütterung

1957 • 22 citations

Neoplastic Transformation in Human Cell Culture: Mechanisms of Carcinogenesis

1991 • 22 citations

Somatic Mutations as a Factor in the Production of Cancer: A Critical Review of v. Hansemann's Theory of Anaplasia in the Light of Modern Knowledge of Genetics

1919 • 22 citations

Reflections on the declining ability of the Salmonella assay to detect rodent carcinogens as positive

1988 • 22 citations

Genetic instability and darwinian selection in tumours

1999 • 21 citations

Evidence that retroviral transduction is mediated by DNA not by RNA.

1990 • 21 citations

Spontaneous and induced chromosomal aberrations and gene mutations in human lymphoblasts: mitomycin C, methylnitrosourea, and ethylnitrosourea

1986 • 21 citations

Aneuploidy

1985 • 19 citations

Neoplastic transformation of hamster embryo cells irradiated in utero and assayed in vitro

1977 • 18 citations

DNA recombination is sufficient for retroviral transduction.

1995 • 18 citations

Karyotype analysis of carcinogen-treated Chinese hamster cells in vitro evolving from a normal to a malignant phenotype

1984 • 17 citations

Molecular heterogeneity in prostate cancer: can TP53 mutation unravel tumorigenesis?

1997 • 17 citations

Biochemistry of Chemical Carcinogenesis

1990 • 16 citations

Heterogeneity of p53 Mutational Status in Esophageal Squamous Cell Carcinoma

1998 • 16 citations

Chemical transformation of Chinese hamster cells: II. Appearance of marker chromosomes in transformed cells

1976 • 16 citations

Karyological instability of neoplastic somatic cells

1975 • 15 citations

How Tumour Suppressor Genes Were Discovered

1993 • 14 citations

Aneuploidy and progression in promoted preneoplastic foci during chemical hepatocarcinogenesis in the rat

1991 • 13 citations

Auto-catalysed progression of aneuploidy explains the Hayflick limit of cultured cells, carcinogen-induced tumours in mice, and the age distribution of human cancer

2000 • 13 citations

Detection of Transforming Genes from Radiation Transformed Human Epidermal Keratinocytes by a Tumorigenicity Assay

1991 • 9 citations

Host range restrictions of oncogenes: myc genes transform avian but not mammalian cells and mht/raf genes transform mammalian but not avian cells.

1996 • 8 citations

Primary Culture of Rat Mammary Epithelial Cells. II. Cytotoxic Effect and Metabolism of 7,12-Dimethylbenz[<italic>a</italic>]anthracene and <italic>N</italic>-Nitroso-<italic>N</italic>-methylurea<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1978 • 8 citations

Auto-catalysed progression of aneuploidy explains the Hayflick limit of cultured cells, carcinogen-induced tumours in mice, and the age distribution of human cancer

2000 • 6 citations

Diskussionsbemerkungen zu dem Vortrag von K. M�hlethaler

1957 • 5 citations

Life is Complicated

2000 • 5 citations

Mechanisms of Chemical Carcinogenesis

1989 • 2 citations