Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers

p53 Mutations in Human Cancers

1991 • 8,133 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Current protocols in molecular biology

1988 • 4,543 citations

ras GENES

1987 • 3,818 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

1982 • 775 citations

Molecular biology of the cell

1993 • 679 citations

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1982 • 599 citations

Molecular cell biology 3.0

1996 • 528 citations

Molecular determinants of dysplasia in colorectal lesions.

1994 • 506 citations

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

1982 • 494 citations

Genetic and physical linkage of exogenous sequences in transformed cells

1980 • 486 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

Correct integration of retroviral DNA in vitro

1987 • 459 citations

Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity?

1984 • 322 citations

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

1995 • 314 citations

Transforming DNA integrates into the host chromosome

1981 • 311 citations

Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture

1985 • 288 citations

Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells.

1982 • 268 citations

Differences between the Ribonucleic Acids of Transforming and Nontransforming Avian Tumor Viruses

1970 • 262 citations

Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.

1986 • 235 citations

ras gene Amplification and malignant transformation.

1985 • 204 citations

Primary Rat Embryo Cells Transformed by One or Two Oncogenes Show Different Metastatic Potentials

1986 • 196 citations

Retroviruses as carcinogens and pathogens: expectations and reality.

1987 • 173 citations

Mutation Affecting the 12th Amino Acid of the c-Ha- ras Oncogene Product Occurs Infrequently in Human Cancer

1983 • 162 citations

The origin of point mutations in human tumor cells.

1992 • 154 citations

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

1994 • 141 citations

Genetic Heterogeneity of the c-K-ras Locus in Colorectal Adenomas but not in Adenocarcinomas

1993 • 136 citations

Predisposition to Neoplastic Transformation Caused by Gene Replacement of H- ras 1

1993 • 117 citations

Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene.

1985 • 117 citations

Avian Tumor Virus RNA: A Comparison of Three Sarcoma Viruses and Their Transformation-Defective Derivatives by Oligonucleotide Fingerprinting and DNA-RNA Hybridization

1973 • 101 citations

Ribonucleic Acid Components of Murine Sarcoma and Leukemia Viruses

1973 • 100 citations

Cloning and analysis of the promotor region of the human fibronectin gene.

1987 • 97 citations

Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells.

1996 • 78 citations

Transfection of Fibroblasts by Cloned Abelson Murine Leukemia Virus DNA and Recovery of Transmissible Virus by Recombination with Helper Virus

1982 • 78 citations

The Molecular Biology of RNA Tumor Viruses

1975 • 64 citations

Harvey ras genes transform without mutant codons, apparently activated by truncation of a 5' exon (exon -1).

1986 • 60 citations

ras gene Amplification and Malignant Transformation

1985 • 57 citations

The Challenge to Man of the Neoplastic Cell

1967 • 50 citations

Harvey murine sarcoma virus: influences of coding and noncoding sequences on cell transformation in vitro and oncogenicity in vivo

1989 • 45 citations

Latent Viruses and Mutated Oncogenes: No Evidence for Pathogenicity

1992 • 41 citations

Overexpression of the N-ras proto-oncogene, not somatic mutational activation, associated with malignant tumors in transgenic mice.

1992 • 39 citations

Transforming function of proto-ras genes depends on heterologous promoters and is enhanced by specific point mutations.

1991 • 34 citations

The secrets of cancer

1982 • 30 citations

Retroviral transduction of oncogenic sequences involves viral DNA instead of RNA.

1988 • 27 citations

Association of genetic alterations of c-myc, c-fos, and c-Ha-ras proto-oncogenes in colorectal tumors

1992 • 24 citations

Augmented Expression of Normal c-myc Is Sufficient for Cotransformation of Rat Embryo Cells with a Mutant ras Gene

1985 • 24 citations

[Oncogenes and cancer].

1988 • 22 citations

myc protooncogene linked to retroviral promoter, but not to enhancer, transforms embryo cells.

1988 • 18 citations

Recombinant BALB and Harvey sarcoma viruses with normal proto-ras-coding regions transform embryo cells in culture and cause tumors in mice

1989 • 15 citations

A retroviral promoter is sufficient to convert proto-src to a transforming gene that is distinct from the src gene of Rous sarcoma virus.

1990 • 13 citations

Avian proto-myc genes promoted by defective or nondefective retroviruses are single-hit transforming genes in primary cells.

1989 • 9 citations

Host range restrictions of oncogenes: myc genes transform avian but not mammalian cells and mht/raf genes transform mammalian but not avian cells.

1996 • 8 citations

Unmutated proto-src coding region is tumorigenic if expressed from the promoter of Rous sarcoma virus: implications for the gene-mutation hypothesis of cancer.

1992 • 7 citations