Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

New Technique for Distinguishing between Human Chromosomes

1971 • 1,168 citations

Telomere end-replication problem and cell aging

1992 • 1,044 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

Transmission of chromosomal instability after plutonium α-particle irradiation

1992 • 603 citations

The use of proteolytic enzymes for the mapping of structural rearrangements in the chromosomes of man

1972 • 461 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

1976 • 274 citations

Telomeres, telomerase and senescence

1990 • 260 citations

Telomere positional effects and the regulation of cellular senescence

1992 • 246 citations

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification

1980 • 234 citations

Senescence of Nickel-Transformed Cells by an X Chromosome: Possible Epigenetic Control

1991 • 188 citations

Differential staining of human and mouse chromosomes in interspecific cell hybrids

1974 • 174 citations

Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens

1982 • 174 citations

Cellular Senescence revisited: a review

1987 • 171 citations

Mutation induction and inactivation in mammalian cells exposed to ionising radiation

1975 • 104 citations

Immortalization of normal human kidney epithelial cells by nickel(II).

1989 • 92 citations

Covalent binding of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxides to DNA: molecular structures, induced mutations and biological consequences

1994 • 88 citations

Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells.

1989 • 76 citations

Comparison of the localization of chromosome damage induced by calcium chromate and nickel compounds.

1987 • 68 citations

Spontaneous Immortalization Rate of Cultured Chinese Hamster Cells2

1986 • 57 citations

Why Are Human Cells Resistant to Malignant Cell Transformation in vitro?¹

1993 • 52 citations

Immortalization of normal human fibroblasts by treatment with 4‐nitroquinoline 1‐oxide

1993 • 51 citations

Identification of Syrian hamster chromosomes by acetic-saline-Giemsa (ASG) and trypsin techniques

1972 • 47 citations

Epithelial Cells: Growth in Culture of Normal and Neoplastic Forms

1975 • 27 citations

Multistep malignant transformation of mammalian cells by carcinogens: induction of immortality as a key event.

1985 • 26 citations

Genome wide spontaneous mutation in human cells determined by the spectrum of mutations in hprt cDNA genes

1993 • 24 citations

Evidence that the first step leading to carcinogen-induced malignant transformation is a high frequency, common event.

1985 • 24 citations

Cell immortalization as a key, rate-limiting event in malignant transformation: approaches toward a molecular genetic analysis

1993 • 19 citations

Immortalization of carcinogen-treated Syrian hamster embryo cells occurs indirectly via an induced process.

1992 • 15 citations

Cellular and Molecular Changes in Mammary Epithelial Cells Following Irradiation

1991 • 9 citations

Malignant transformation of mammalian cells in culture: delineation of stages and role of cellular oncogene activation.

1985 • 9 citations

Morphological transformation of immortalized hamster dermal fibroblasts following treatment with simple alkylating carcinogens

1988 • 8 citations