Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

New Giemsa method for the differential staining of sister chromatids

1974 • 3,198 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Cytological detection of mutagen–carcinogen exposure by sister chromatid exchange

1975 • 1,333 citations

A cancer family syndrome in twenty-four kindreds.

1988 • 1,274 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Chromosome Aberrations and Cancer

1991 • 598 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

1993 • 471 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

Rhabdomyosarcoma in Children: Epidemiologic Study and Identification of a Familial Caneer Syndrome

1969 • 398 citations

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

1994 • 366 citations

Sister chromatid exchanges induced in chinese hamster cells by UV irradiation of different stages of the cell cycle: The necessity for cells to pass through S

1974 • 312 citations

Evidence for a second cell cycle block at G2/M by p53.

1995 • 306 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 305 citations

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.

1994 • 295 citations

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

1990 • 256 citations

Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells

1991 • 248 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

Sister chromatid exchanges—A sensitive assay of agents damaging human chromosomes

1975 • 204 citations

Factors Affecting and Significance of G₂Chromatin Radiosensitivity in Predisposition to Cancer

1989 • 125 citations

Cytogenetic Response to G 2 -Phase X Irradiation in Relation to DNA Repair and Radiosensitivity in a Cancer-Prone Family with Li-Fraumeni Syndrome

1993 • 51 citations

The relationship between the cell time available for repair and the effectiveness of a damaging treatment in provoking the formation of sister-chromatid exchanges

1980 • 43 citations

Cytogenetic methods for the mouse: Preparation of chromosomes, karyotyping, and in situ hybridization

1990 • 40 citations

Detection of Cancer-Prone Individuals Using Cytogenetic Response to X-Rays

1990 • 23 citations

An automated system for karyotyping mouse chromosomes

1989 • 19 citations