Mechanism of activation of a human oncogene

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

1975 • 3,362 citations

Biophysical chemistry

1979 • 1,709 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

1980 • 1,285 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.

1976 • 850 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1981 • 795 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

1982 • 775 citations

T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

1982 • 617 citations

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1982 • 599 citations

Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion

1981 • 533 citations

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

1982 • 494 citations

Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.

1979 • 491 citations

Human-tumor-derived cell lines contain common and different transforming genes

1981 • 455 citations

Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus

1980 • 387 citations

Transforming activity of human tumor DNAs.

1981 • 374 citations

Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state

1981 • 346 citations

Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses.

1982 • 309 citations

Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.

1981 • 302 citations

Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus

1982 • 272 citations

Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus

1979 • 270 citations

Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells.

1982 • 268 citations

Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus

1982 • 256 citations

Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus

1981 • 253 citations

Activation of the Transforming Potential of a Normal Cell Sequence: A Molecular Model for Oncogenesis

1981 • 246 citations

Transforming activity of DNA of chemically transformed and normal cells

1980 • 234 citations

A defined subgenomic fragment of in vitro synthesized Moloney sarcoma virus DNA can induce cell transformation upon transfection

1979 • 187 citations

Short term screening tests for carcinogens

1976 • 177 citations

Harvey Sarcoma Virus: A Second Murine Type C Sarcoma Virus with Rat Genetic Information

1974 • 165 citations

Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus

1982 • 151 citations

Activation of related transforming genes in mouse and human mammary carcinomas.

1981 • 139 citations

Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens

1976 • 120 citations

Comparison of the genomic organization of Kirsten and Harvey sarcoma viruses

1978 • 106 citations

Unique transforming gene in carcinogen-transformed mouse cells

1981 • 101 citations

A rapid enzymatic DNA sequencing technique: determination of sequence alterations in early simian virus 40 temperature sensitive and deletion mutants

1980 • 78 citations

Microbial testers : probing carcinogenesis

1981 • 12 citations