Mutagenesis by chemical agents in V79 Chinese hamster cells: A review and analysis of the literature

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States.

1968 • 1,105 citations

Chemical Carcinogenesis

1975 • 741 citations

Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system

1979 • 567 citations

Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules.

1966 • 489 citations

Ouabain-resistant mutants of mouse and hamster cells in culture

1974 • 393 citations

Cancer Mortality Among the Foreign-Born in the United States

1961 • 305 citations

Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

1976 • 274 citations

8-AZAGUANINE RESISTANCE IN MAMMALIAN CELLS I. HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE

1972 • 273 citations

Cell‐mediated mutagenesis of mammalian cells with chemical carcinogens

1974 • 243 citations

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification

1980 • 234 citations

Chapter 7: Isolation of Mutants of Cultured Mammalian Cells

1973 • 232 citations

Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.

1976 • 232 citations

Human Bone Marrow Mesenchymal Stem Cell Behaviors on PCL/Gelatin Nanofibrous Scaffolds Modified with A Collagen IV-Derived RGD-Containing Peptide.

2014 • 215 citations

The Mutagenicity of Chemical Carcinogens: Correlations, Problems, and Interpretations

1971 • 201 citations

A Survey of Chemicals for Mutagenic Action on E. coli

1951 • 191 citations

High mutagenicity and toxicity of a diol epoxide derived from benzo[a]pyrene

1976 • 188 citations

Evaluation of the carcinogenicity of chemicals: a review of the Monograph Program of the International Agency for Research on Cancer (1971 to 1977).

1978 • 186 citations

Maintenance of cytochrome P-450 and metabolism of aflatoxin B1 in primary hepatocyte cultures

1977 • 178 citations

Resistance of cultured human fibroblasts and other cells to purine and pyrimidine analogues in relation to mutagenesis detection

1974 • 174 citations

Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides

1977 • 172 citations

Linear dose —response relationships after prolonged expression times in V-79 Chinese hamster cells

1976 • 172 citations

Mutation rates in cells at different ploidy levels

1971 • 171 citations

Mutagenicity and cytotoxicity of benzo(a)pyrene arene oxides, phenols, quinones, and dihydrodiols in bacterial and mammalian cells.

1976 • 161 citations

A comparison of the 8-azaguanine and ouabain-resistance systems for the selection of induced mutant Chinese hamster cells

1975 • 157 citations

A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): Utilization with a variety of mutagenic agents

1977 • 151 citations

Liver homogenate-mediated mutagenesis in Chinese hamster V79 cells by polycyclic aromatic hydrocarbons and aflatoxins

1977 • 150 citations

The HPRT locus

1979 • 146 citations

The effect of ploidy on chemical mutagenesis in cultured chinese hamster cells

1973 • 139 citations

Do radiation-induced thioguanine-resistant mutants of cultured mammalian cells arise by HGPRT gene mutation or X-chromosome rearrangement?

1978 • 126 citations

The enhancement by caffeine of alkylation-induced cell death, mutations and chromosomal aberrations in Chinese hamster cells, as a result of inhibition of post-replication DNA repair

1974 • 120 citations

Mutagenicity and toxicity of visible fluorescent light to cultured mammalian cells

1977 • 114 citations

Mutagenicity of thymidine to cultured Chinese hamster cells

1978 • 107 citations

Human pulmonary alveolar macrophages metabolise benzo(a)pyrene to proximate and ultimate mutagens

1978 • 103 citations

Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin.

1976 • 102 citations

Microsome-mediated mutagenesis in V79 Chinese hamster cells by various nitrosamines.

1977 • 102 citations

Mammalian cell genetics III. Characterization of x-ray-induced forward mutations in chinese hamster cell cultures

1971 • 101 citations

Differences between products of binding of 7,12-dimethylbenz[a]anthracene to DNA in mouse skin and in a rat liver microsomal system

1978 • 100 citations

Inhibition of repair of UV-damaged DNA by caffeine and mutation induction in Chinese hamster cells

1973 • 98 citations

Effect of phorbol myristate acetate on the recovery of spontaneous and ultraviolet light-induced 6-thioguanine and ouabain-resistant Chinese hamster cells.

1977 • 97 citations

The Host-Mediated Assay, a Practical Procedure for Evaluating Potential Mutagenic Agents in Mammals

1971 • 97 citations

Mutagenicity of industrial compounds: Styrene and its possible metabolite styrene oxide

1976 • 94 citations

Cell specificity in metabolic activation of aflatoxin B1 and benzo(a)pyrene to mutagens for mammalian cells

1978 • 87 citations

The mutagenicity to mammalian cells of pyrimidine nucleoside analogs

1972 • 86 citations

Mutation induction in chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2‐chloroacetaldehyde

1975 • 84 citations

Mutagenicity of fume particles from stainless steel welding.

1977 • 82 citations

The role of metabolic cooperation in selection of hypoxanthine-guanine-phosphoribosyl-transferase (HG-PRT)-deficient mutants from diploid mammalian cell strains

1972 • 82 citations

Enhancement by caffeine of N-methyl-N-nitrosourea-induced mutations and chromosome aberrations in chinese hamster cells

1973 • 79 citations

Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells

1977 • 79 citations

Mutagenesis of Chinese hamster cells is facilitated by thymidine and deoxycytidine

1978 • 79 citations

Induction and Analysis of Gene Mutations in Mammalian Cells in Culture

1971 • 78 citations

Metabolism of polycyclic aromatic hydrocarbons in cell cultuires.

1971 • 77 citations

The induction of azaguanine-resistant mutants in cultured Chinese hamster cells by reactive derivatives of carcinogenic hydrocarbons.

1973 • 76 citations

The selection of Chinese hamster cells deficient in oxidative energy metabolism

1976 • 73 citations

Cell-mediated mutagenesis in cultured Chinese hamster cells by carcinogenic polycyclic hydrocarbons: Nature and extent of the associated hydrocarbon-DNA reaction

1977 • 71 citations

REQUIREMENT FOR CELL DISPERSION PRIOR TO SELECTION OF INDUCED AZAGUANINE-RESISTANT COLONIES OF CHINESE HAMSTER CELLS

1975 • 68 citations

GALACTOKINASE MUTANTS OF CHINESE HAMSTER SOMATIC CELLS RESISTANT TO 2-DEOXYGALACTOSE

1976 • 67 citations

Carcinogenicity and mutagenicity of benz(a)anthracene diols and diol-epoxides.

1978 • 67 citations

The induction of azaguanine-resistant mutants in cultured Chinese hamster cells by reactive derivatives of carcinogenic hydrocarbons

1973 • 65 citations

A sensitive hepatocyte-mediated assay for the metabolism of nitrosamines to mutagens for mammalian cells.

1980 • 64 citations

Metabolic activation of 3-methylcholanthrene and its metabolites to products mutagenic to bacterial and mammalian cells.

1978 • 62 citations

Benzo[α]pyrene carcinogenesis: A biochemical selection mechanism

1977 • 62 citations

Mutation to ouabain-resistance in Chinese hamster cells: Induction by ethyl methanesulphonate and lack of induction by ionising radiation

1978 • 62 citations

DERIVATION OF TK- CLONES FROM REVERTANT TK+ MAMMALIAN CELLS

1973 • 61 citations

Mutation to 8-azaguanine resistance induced by γ-radiation in a chinese hamster cell line

1971 • 60 citations

Effect of tumor promoting agents on mutation frequencies in cultured V79 Chinese hamster cells

1977 • 58 citations

Factors affecting the quantitation of dose-response curves for mutation induction in V79 Chinese hamster cells after exposure to chemical and physical mutagens

1975 • 57 citations

Factors affecting the efficiency of purine analogues as selective agents for mutants of mammalian cells induced by ionising radiation

1976 • 57 citations

Effects of caffeine on the induction of mutations in Chinese hamster cells by ultraviolet light

1971 • 57 citations

Direct or proximate contact between cells and metabolic activation systems is required for mutagenesis

1978 • 57 citations

(Na,K)ATPase Activity in Membrane Preparations of Ouabain-Resistant HeLa Cells

1977 • 56 citations

The metabolic activation of 7-methylbenz(a)anthracene: The induction of malignant transformation and mutation in mammalian cells by non-K-region dihydrodiols

1977 • 50 citations

Effects of harman and norharman on spontaneous and ultraviolet light-induced mutagenesis in cultured Chinese hamster cells.

1978 • 50 citations

The effect of post-treatment with caffeine on survival and UV-induced mutation frequencies in chinese hamster and mouse lymphoma cells in vitro

1974 • 50 citations

Characterization of ultraviolet light-induced ouabain-resistant mutations in chinese hamster cells

1978 • 49 citations

A comparative study of different experimental protocols for mutagenesis assys with the 9-azaguanine resistance system in cultured Chinese hamster cells

1976 • 48 citations

Ouabain‐resistant human lymphoblastoid lines altered in the (Na⁺ + K⁺)‐dependent ATPase membrane transport system

1976 • 46 citations

Mammalian cell transformation and cell-mediated mutagenesis by carcinogenic polycyclic hydrocarbons

1975 • 46 citations

Cytogenetic and mutagenic effects of DDT and DDE in a Chinese hamster cell line

1973 • 46 citations

Effect of alkane tumor‐promoting agents on chemically induced mutagenesis in cultured v79 Chinese hamster cells

1978 • 45 citations

Oncogenesis, mutagenesis, DNA damage, and cytotoxicity in cultured mammalian cells treated with alkylating agents.

1979 • 45 citations

Contact-mediated communication of ouabain resistance in mammalian cells in culture

1977 • 44 citations

Mutagenicity and cytotoxicity of various nitrosoureas in V-79 Chinese hamster cells.

1980 • 43 citations

Induction of 6-thioguanine-resistant mutants in V79 Chinese hamster cells by mouse-liver microsome-activated dimethylnitrosamine

1977 • 42 citations

Malignant transformation and mutagenesis in mammalian cells induced by vicinal diol-epoxides derived from benzo(a)pyrene

1977 • 42 citations

The influence of serum components on the growth and mutation of Chinese hamster cells in medium containing 8-azaguanine

1976 • 41 citations

Modification of UV-induced mutation frequencies in Chinese hamster cells by dose fractionation, cycloheximide and caffeine treatments

1978 • 41 citations

Mutation and Transformation of Cultured Mammalian Cells by <italic>N</italic>-Acetoxy-<italic>N</italic>-2-Fluorenylacetamide

1972 • 41 citations

Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids

1979 • 41 citations

Mutagenesis by simian virus 40. I. Detection of mutations in Chinese hamster cell lines using different resistance markers

1976 • 41 citations

Chromosomal damage and mutations after exposure of chinese hamster cells to high concentrations of oxygen

1978 • 39 citations

LACK OF MUTAGENIC EFFECT OF HALOTHANE OR CHLOROFORM ON CULTURED CELLS USING THE AZAGUANINE TEST SYSTEM

1977 • 39 citations

Correlation between species life span and capacity to activate 7,12-dimethylbenz(a)anthracene to a form mutagenic to a mammalian cell

1975 • 38 citations

The importance of the “bay region” diol-epoxide in 7,12-dimethylbenz[a]anthracene skin tumor initiation and mutagenesis

1979 • 35 citations

Photoactivation of chlorpromazine: cytogenetic and mutagenic effects.

1973 • 35 citations

Biological and biochemical characterisation of purine analogue resistant clones of V79 Chinese hamster cells

1976 • 35 citations

Failure of caffeine to influence induced mutation frequencies and the independence of cell killing and mutation induction in V79 Chinese hamster cells

1979 • 34 citations

Facilitation by pyrimidine deoxyribonucleosides and hypoxanthine of mutagenic and cytotoxic effects of monofunctional alkylating agents in Chinese hamster cells

1979 • 33 citations

Photoactivation of chlorpromazine: Cytogenetic and mutagenic effects

1973 • 31 citations

Conditions necessary for quantifying ethyl methanesulfonate-induced mutations to purine-analogue resistance in Chinese hamster V79 cells

1978 • 31 citations

The relative effectiveness of 6-thioguanine and 8-azaguanine in selecting resistant mutants from two V79 Chinese hamster cells in vitro

1976 • 31 citations

The induction of ouabain-resistant mutants by N-methyl-N′-nitro-N-nitrosoguanidine in Chinese hamster cells

1974 • 30 citations

Pesticide induced ouabain resistant mutants in Chinese hamster V79 cells

1977 • 30 citations

TEMPERATURE-SENSITIVE MUTANTS OF A CHINESE HAMSTER CELL LINE. I. SELECTION OF CLONES WITH DEFECTIVE MACROMOLECULAR BIOSYNTHESIS

1975 • 29 citations

Further evidence for the genetic origin of mutations in mammalian somatic cells: The effects of ploidy level and selection stringency on dose-dependent chemical mutagenesis to purine analogue resistance in Chinese hamster ovary cells

1977 • 28 citations

Mutagenicity of the food additive AF-2, a nitrofuran, in Escherichia coli and Chinese hamster cells in culture

1975 • 28 citations

Culture of adult rat lung cells: Benzo(a)pyrene metabolism and mutagenesis

1979 • 26 citations

5-Bromodeoxyuridine mutagenesis in synchronous hamster cells

1976 • 26 citations

Mutations affecting the antigenic properties of hypoxanthine-guanine phosphoribosyl transferase in cultured Chinese hamster cells

1977 • 25 citations

Study of trans-cyclopropylbis(diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis

1977 • 25 citations

Spontaneous, chemical and viral mutagenesis in temperature-sensitive glutamine-requiring chinese hamster cells

1977 • 25 citations

Mutagenesis by Simian virus 40. II. Changes in substrate affinities in mutant hypoxanthine-guanine phosphoribosyl transferase enzymes at different pH values

1977 • 24 citations

Reversion of the 8-azaguanine resistant phenotype of variant Chinese hamster cells treated with alkylating agents and 5-bromo-2′-deoxyuridine

1975 • 24 citations

The effect of variable serum factors and clonal morphology on the ability to detect hypoxanthine guanine phosphoribosyl transferase (HPRT) deficient variants in cultured Chinese hamster cells

1975 • 23 citations

Comparative Frequency of Dominant and Recessive Markers for Drug Resistance in Chinese Hamster Cells 2

1974 • 22 citations

Enzyme activities in extracts of 8-azaguanine-resistant mutants of cultured chinese hamster cells induced by the carcinogen, 7-bromomethylbenz[α]anthracene

1974 • 22 citations

Mutation induction by the antischistosomal drug F30066 in various test systems

1977 • 21 citations

Reversion of 6-thioguanine resistant Chinese hamster cell lines: agent specificity and evidence for the repair of promutagenic lesions

1980 • 20 citations

Serum effect on the yield of chemically induced 8-azaguanine-resistant mutants in Chinese hamster cell cultures

1974 • 20 citations

Post-treatment with caffeine and the induction of gene mutations by ultraviolet irradiation and ethyl methanesulphonate in V-79 Chinese hamster cells in culture

1978 • 20 citations

Metabolic activation of 3-methylcholanthrene: Mutagenic and transforming activities of the 9,10-dihydrodiol

1978 • 20 citations

Isolation and characterization of temperature-sensitive mutants in a Chinese hamster cell line

1973 • 19 citations

The influence of serum components on the growth and mutation of Chinese hamster cells in medium containing aminopterin

1974 • 19 citations

The expression curve of mutants induced by styrene oxide at the HGPRT locus in V79 cells

1978 • 17 citations

Cytotoxicity, mutations and DNA damage produced in Chinese hamster cells treated with streptozotocin, its analogs, and N-methyl-N′-nitro-N-nitrosoguanidine

1976 • 16 citations

Mutagenicity to mammalian cells in culture by (+) and (−) trans-7, 8-dihydroxy-7, 8-dihydrobenzo(a)pyrenes and the hydrolysis and reduction products of two stereoisomeric benzo(a)pyrene 7, 8-diol-9, 10-epoxides

1978 • 16 citations

Cytotoxicity and mutagenicity of ultraviolet irradiation as a function of the interval between split doses in cultured Chinese hamster cells

1973 • 14 citations

Evidence for dominant mutations reducing HGPRT activity

1978 • 14 citations

Factors affecting the growth of Chinese hamster cells in halt selection media

1976 • 14 citations

Detection of antigenically active mutant HGPRT after mutagenesis with simian virus 40

1978 • 11 citations

Estimation of the effects of chemical mutagens: Lessons from radiation genetics

1975 • 9 citations

NO MUTAGENIC EFFECT OF ENFLURANE ON CULTURED CELLS

1977 • 9 citations

Effect of cell growth rate and dose fractionation on chemically-induced ouabain-resistant mutations in Chinese hamster V79 cells

1979 • 8 citations

Isolation of mammalian cell mutants deficient in glucose 6-phosphate dehydrogenase by means of a replica-plating technique

1976 • 5 citations