p53 gene mutations are not required for early dissemination of cancer cells

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Karyotyping human chromosomes by combinatorial multi-fluor FISH

1996 • 1,265 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer

1998 • 976 citations

Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies

1996 • 666 citations

Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients

1992 • 563 citations

Differential Expression of Proliferation-Associated Molecules in Individual Micrometastatic Carcinoma Cells

1993 • 514 citations

Micrometastatic Breast Cancer Cells in Bone Marrow at Primary Surgery: Prognostic Value in Comparison With Nodal Status

1996 • 491 citations

Detection and viability of tumor cells in peripheral blood stem cell collections from breast cancer patients using immunocytochemical and clonogenic assay techniques [see comments]

1993 • 462 citations

Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases.

1991 • 454 citations

Nucleic Acid-Based Methods for the Detection of Cancer

1997 • 409 citations

Prognostic Value of Immunohistochemically Identifiable Tumor Cells in Lymph Nodes of Patients with Completely Resected Esophageal Cancer

1997 • 370 citations

Detection and viability of tumor cells in peripheral blood stem cell collections from breast cancer patients using immunocytochemical and clonogenic assay techniques [see comments]

1993 • 359 citations

Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases

1996 • 314 citations

Multiple Mutation Analyses in Single Tumor Cells with Improved Whole Genome Amplification

1999 • 262 citations

Individual development and uPA–receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer

1995 • 253 citations

Frequent down-regulation of major histocompatibility class I antigen expression on individual micrometastatic carcinoma cells.

1991 • 227 citations

Epithelial tumor cells in bone marrow of patients with colorectal cancer: immunocytochemical detection, phenotypic characterization, and prognostic significance.

1990 • 209 citations

Prognostic significance of bone marrow micrometastases in patients with gastric cancer.

1996 • 195 citations

Cancer dormancy: Opportunities for new therapeutic approaches

1997 • 192 citations

Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: establishment of working models for human micrometastases.

1999 • 187 citations

p53 and K-RAS alterations in pancreatic epithelial cell lesions.

1993 • 186 citations

Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages

1994 • 179 citations

Detection of Occult Bone Marrow Micrometastases in Patients with Operable Lung Carcinoma

1995 • 170 citations

Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture

1992 • 170 citations

Tumor antigens recognized by T lymphocytes

1997 • 153 citations

Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages

1994 • 142 citations

Establishment of Micrometastatic Carcinoma Cell Lines: a Novel Source of Tumor Cell Vaccines

1995 • 127 citations

Review article: Micrometastasis in colorectal carcinoma: A review

1998 • 106 citations

Micrometastatic p53-positive cells in the lymph nodes of non-small-cell lung cancer: Prognostic significance

1997 • 100 citations

Immunocytochemical Detection of Disseminated Tumor Cells in the Bone Marrow of Patients With Esophageal Carcinoma

1996 • 99 citations

Epitope Specificity of 30 Monoclonal Antibodies against Cytokeratin Antigens: The ISOBM TD5-1 Workshop

1998 • 80 citations

Detection of genetic alterations in micrometastatic cells in bone marrow of cancer patients by fluorescence in situ hybridization

1996 • 77 citations

Prognostic significance of micrometastatic bone marrow involvement

1998 • 63 citations

NON‐RADIOACTIVE OLIGOTYPING FOR HLA‐DR1‐DRw10 USING POLYMERASE CHAIN REACTION, DIGOXIGENIN‐LABELLED OLIGONUCLEOTIDES AND CHEMILUMINESCENCE DETECTION

1991 • 58 citations

Development of Cancer Vaccine by Tumor Rejection Antigens

1997 • 7 citations