Cellular Control of Actin Nucleation

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

A homochiral metal–organic porous material for enantioselective separation and catalysis

2000 • 3,832 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells

2000 • 1,471 citations

The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments

1998 • 1,388 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.

1989 • 1,268 citations

Enteropathogenic E. coli (EPEC) Transfers Its Receptor for Intimate Adherence into Mammalian Cells

1997 • 1,168 citations

Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

1999 • 1,150 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Filamins as integrators of cell mechanics and signalling

2001 • 987 citations

Reconstitution of actin-based motility of Listeria and Shigella using pure proteins

1999 • 968 citations

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

1998 • 933 citations

Control of Cell Shape in Bacteria

2001 • 912 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

Cytoskeletal dynamics and nerve growth

1988 • 855 citations

Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility

2002 • 828 citations

Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments.

1986 • 828 citations

Prokaryotic origin of the actin cytoskeleton

2001 • 809 citations

L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein

1992 • 790 citations

Actin microfilament dynamics in locomoting cells

1991 • 789 citations

Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex

1999 • 771 citations

Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein

2000 • 739 citations

Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

1989 • 724 citations

SalmonellaInteractions with Host Cells: Type III Secretion at Work

2001 • 710 citations

Analysis of the Actin–Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body Translocation

1997 • 700 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

Phagocytosis and the actin cytoskeleton

2001 • 689 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling.

1985 • 637 citations

Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate

2000 • 615 citations

Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes

1997 • 598 citations

Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

2001 • 585 citations

Activation of Arp2/3 complex-mediated actin polymerization by cortactin

2001 • 561 citations

Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins

2000 • 558 citations

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

2000 • 550 citations

A Role for Cdc42 in Macrophage Chemotaxis

1998 • 537 citations

Crystal Structure of Arp2/3 Complex

2001 • 531 citations

Activation of the Cdc42 Effector N-Wasp by the Shigella flexneri Icsa Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility

1999 • 513 citations

The Human Arp2/3 Complex Is Composed of Evolutionarily Conserved Subunits and Is Localized to Cellular Regions of Dynamic Actin Filament Assembly

1997 • 504 citations

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3

2000 • 501 citations

Interaction of Human Arp2/3 Complex and the Listeria monocytogenes ActA Protein in Actin Filament Nucleation

1998 • 500 citations

Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex

2000 • 498 citations

Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose.

1994 • 484 citations

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

1995 • 479 citations

Single-Molecule Speckle Analysis of Actin Filament Turnover in Lamellipodia

2002 • 478 citations

Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast

2001 • 472 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Actin-Dependent Propulsion of Endosomes and Lysosomes by Recruitment of N-Wasp✪

2000 • 444 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

Actin-based motility of vaccinia virus

1995 • 426 citations

Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages.

1996 • 423 citations

Molecular Links between Endocytosis and the Actin Cytoskeleton

2000 • 417 citations

Mena Is Required for Neurulation and Commissure Formation

1999 • 415 citations

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

1997 • 414 citations

A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin.

1992 • 411 citations

Cortactin Localization to Sites of Actin Assembly in Lamellipodia Requires Interactions with F-Actin and the Arp2/3 Complex

2000 • 410 citations

Regulated Actin Cytoskeleton Assembly at Filopodium Tips Controls Their Extension and Retraction

1999 • 408 citations

diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene

1994 • 408 citations

Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling

1999 • 407 citations

Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex

2001 • 404 citations

Myosin Drives Retrograde F-Actin Flow in Neuronal Growth Cones

1996 • 403 citations

Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway

2001 • 400 citations

Yeast formins regulate cell polarity by controlling the assembly of actin cables

2001 • 396 citations

Regulated Interactions between Dynamin and the Actin-Binding Protein Cortactin Modulate Cell Shape

2000 • 391 citations

Actin Assembly Plays a Variable, but not Obligatory Role in Receptor‐Mediated Endocytosis

2000 • 385 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

Antigen Receptor–Induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein–Deficient Lymphocytes

1999 • 367 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Myosin-X is an unconventional myosin that undergoes intrafilopodial motility

2002 • 362 citations

Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP

2001 • 357 citations

Role of Proteins of the Ena/VASP Family in Actin-based Motility of Listeria monocytogenes

1999 • 356 citations

Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells

2001 • 354 citations

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

1998 • 353 citations

AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis

1998 • 345 citations

Organization of actin in the leading edge of cultured cells: influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks.

1981 • 340 citations

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

2001 • 338 citations

Animal Cell Cytokinesis

2001 • 337 citations

Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3

2000 • 325 citations

Endocytic vesicles move at the tips of actin tails in cultured mast cells

1999 • 325 citations

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

2000 • 323 citations

Identification of a Carboxyl-terminal Diaphanous-related Formin Homology Protein Autoregulatory Domain

2001 • 322 citations

Cofilin Produces Newly Polymerized Actin Filaments that Are Preferred for Dendritic Nucleation by the Arp2/3 Complex

2002 • 320 citations

Mechanism of Interaction of Acanthamoeba Actophorin (ADF/Cofilin) with Actin Filaments

1999 • 319 citations

A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

2000 • 318 citations

Motility of ActA protein-coated microspheres driven by actin polymerization

1999 • 315 citations

Syndapin Isoforms Participate in Receptor-Mediated Endocytosis and Actin Organization

2000 • 309 citations

Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity.

1992 • 305 citations

Syndapin I, a Synaptic Dynamin-binding Protein that Associates with the Neural Wiskott-Aldrich Syndrome Protein

1999 • 299 citations

Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis

2001 • 287 citations

Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus

2001 • 281 citations

Influence of the C Terminus of Wiskott-Aldrich Syndrome Protein (WASp) and the Arp2/3 Complex on Actin Polymerization

1999 • 277 citations

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

1999 • 275 citations

Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks

2000 • 274 citations

A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells.

1995 • 272 citations

Polarity of actin at the leading edge of cultured cells

1978 • 268 citations

Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis

1999 • 265 citations

The Wiskott–Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex

1999 • 263 citations

Role of Type I Myosins in Receptor-Mediated Endocytosis in Yeast

1996 • 263 citations

Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy

2001 • 263 citations

The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro

2001 • 261 citations

Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N‐WASP‐defective cells

2001 • 260 citations

How is actin polymerization nucleated in vivo?

2001 • 258 citations

SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila

2002 • 257 citations

Fc receptor-mediated phagocytosis requires CDC42 and Rac1

1998 • 254 citations

Structure of Arp2/3 Complex in Its Activated State and in Actin Filament Branch Junctions

2001 • 251 citations

The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches

1997 • 249 citations

A Role for Myosin-I in Actin Assembly through Interactions with Vrp1p, Bee1p, and the Arp2/3 Complex

2000 • 248 citations

INTRACELLULAR PATHOGENS AND THE ACTIN CYTOSKELETON

1998 • 248 citations

Cross-linker dynamics determine the mechanical properties of actin gels

1994 • 246 citations

Profilin I is essential for cell survival and cell division in early mouse development

2001 • 244 citations

The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins

2000 • 242 citations

Thermodynamics and Kinetics of Actin Filament Nucleation

2001 • 242 citations

Phosphorylation of tyrosine 474 of the enteropathogenic Escherichia coli (EPEC) Tir receptor molecule is essential for actin nucleating activity and is preceded by additional host modifications

1999 • 241 citations

Directional actin polymerization associated with spotted fever group Rickettsia infection of Vero cells

1993 • 237 citations

Actin filament organization in the fish keratocyte lamellipodium.

1995 • 236 citations

Dynamin at actin tails

2002 • 236 citations

Mammalian Abp1, a Signal-Responsive F-Actin–Binding Protein, Links the Actin Cytoskeleton to Endocytosis via the Gtpase Dynamin

2001 • 234 citations

Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein

1999 • 231 citations

Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility.

1995 • 231 citations

The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis.

1994 • 228 citations

The large GTPase dynamin regulates actin comet formation and movement in living cells

2002 • 224 citations

Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri

1998 • 224 citations

The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments

2001 • 223 citations

Direct Involvement of Yeast Type I Myosins in Cdc42-Dependent Actin Polymerization

2000 • 223 citations

Pan1p, Yeast eps15, Functions as a Multivalent Adaptor That Coordinates Protein–Protein Interactions Essential for Endocytosis

1998 • 220 citations

Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts

1998 • 219 citations

A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15.

1996 • 217 citations

An Actin-Binding Protein of the Sla2/Huntingtin Interacting Protein 1 Family Is a Novel Component of Clathrin-Coated Pits and Vesicles

1999 • 217 citations

Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals

1999 • 215 citations

A Requirement for ARF6 in Fcγ Receptor-mediated Phagocytosis in Macrophages

1998 • 211 citations

The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin.

1996 • 208 citations

Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin

2001 • 207 citations

Activation of the Arp2/3 Complex by the Actin Filament Binding Protein Abp1p

2001 • 207 citations

Phosphorylation of Adf/Cofilin Abolishes Egf-Induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension

2000 • 206 citations

eps15 and eps15R are essential components of the endocytic pathway.

1997 • 201 citations

Relationship between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells after Epidermal Growth Factor Stimulation

1999 • 199 citations

Dictyostelium myosin I double mutants exhibit conditional defects in pinocytosis.

1995 • 198 citations

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

2000 • 197 citations

Dynamin family of mechanoenzymes

2001 • 197 citations

FH proteins as cytoskeletal organizers

1998 • 195 citations

Sequences, structural models, and cellular localization of the actin-related proteins Arp2 and Arp3 from Acanthamoeba.

1995 • 191 citations

Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells

2001 • 190 citations

The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42

1998 • 188 citations

Genetic dissection of the budding yeast Arp2/3 complex: A comparison of the in vivo and structural roles of individual subunits

1999 • 187 citations

Chemotactic peptide-induced changes in neutrophil actin conformation.

1984 • 186 citations

Three Regions within Acta Promote Arp2/3 Complex-Mediated Actin Nucleation and Listeria monocytogenes Motility

2000 • 185 citations

A role for cofilin and LIM kinase inListeria-induced phagocytosis

2001 • 185 citations

Dynamic Cross-linking by α-Actinin Determines the Mechanical Properties of Actin Filament Networks

1998 • 184 citations

Actin from Thyone sperm assembles on only one end of an actin filament: a behavior regulated by profilin.

1983 • 180 citations

Mechanism of the formation of contractile ring in dividing cultured animal cells. II. Cortical movement of microinjected actin filaments.

1990 • 177 citations

Dictyostelium mutants lacking multiple classic myosin I isoforms reveal combinations of shared and distinct functions.

1996 • 176 citations

The unrelated surface proteins ActA of Listeria monocytogenes and lcsA of Shigella flexneri are sufficient to confer actin‐based motility on Listeria innocua and Escherichia coli respectively

1995 • 176 citations

Fission Yeast Myosin-I, Myo1p, Stimulates Actin Assembly by Arp2/3 Complex and Shares Functions with Wasp

2000 • 175 citations

Formation of filopodia in coelomocytes: Localization of Fascin, a 58,000 Dalton actin cross-linking protein

1979 • 173 citations

Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex

2001 • 172 citations

The Dictyostelium Carmil Protein Links Capping Protein and the Arp2/3 Complex to Type I Myosins through Their Sh3 Domains

2001 • 172 citations

Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles

2000 • 169 citations

A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex

2002 • 166 citations

The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development

1996 • 161 citations

The WASp homologue Las17p functions with the WIP homologue End5p/verprolin and is essential for endocytosis in yeast

1998 • 161 citations

Regulation of Actin Polymerization in Cell-free Systems by GTPγS and Cdc42

1997 • 160 citations

Reconstitution of Human Arp2/3 Complex Reveals Critical Roles of Individual Subunits in Complex Structure and Activity

2001 • 160 citations

Mechanism of the formation of contractile ring in dividing cultured animal cells. I. Recruitment of preexisting actin filaments into the cleavage furrow.

1990 • 157 citations

Contraction and polymerization cooperate to assemble and close actomyosin rings around Xenopus oocyte wounds

2001 • 155 citations

Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities

2001 • 153 citations

Redundancy in the microfilament system: Abnormal development of dictyostelium cells lacking two F-actin cross-linking proteins

1992 • 151 citations

The yeast actin-related protein Arp2p is required for the internalization step of endocytosis.

1997 • 150 citations

Association of Mouse Actin-binding Protein 1 (mAbp1/SH3P7), an Src Kinase Target, with Dynamic Regions of the Cortical Actin Cytoskeleton in Response to Rac1 Activation

2000 • 149 citations

The amino‐terminal part of ActA is critical for the actin‐based motility of Listeria monocytogenes; the central proline‐rich region acts as a stimulator

1995 • 146 citations

Comparison of actin and cell surface dynamics in motile fibroblasts.

1992 • 146 citations

The bacterial actin nucleator protein ActA of Listeria monocytogenes contains multiple binding sites for host microfilament proteins

1995 • 141 citations

Actin-based movement of Listeria monocytogenes: actin assembly results from the local maintenance of uncapped filament barbed ends at the bacterium surface.

1995 • 141 citations

Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis

2001 • 138 citations

Molecular requirements for the internalisation step of endocytosis: insights from yeast

2001 • 137 citations

Generation and characterization of Dictyostelium cells deficient in a myosin I heavy chain isoform.

1990 • 137 citations

Identification of two regions in the N-terminal domain of ActA involved in the actin comet tail formation by Listeria monocytogenes

1997 • 135 citations

The Intersectin 2 Adaptor Links Wiskott Aldrich Syndrome Protein (WASp)-mediated Actin Polymerization to T Cell Antigen Receptor Endocytosis

2001 • 133 citations

The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension

2001 • 133 citations

Actin Assembly at Membranes Controlled by ARF6

2000 • 132 citations

Pivotal role of VASP in Arp2/3 complex–mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility

2001 • 132 citations

Asymmetric distribution of the Listeria monocytogenes ActA protein is required and sufficient to direct actin‐based motility

1995 • 131 citations

Why Are Two Different Cross-linkers Necessary for Actin Bundle Formation In Vivo and What Does Each Cross-link Contribute?

1998 • 130 citations

The Schizosaccharomyces pombe actin-related protein, Arp3, is a component of the cortical actin cytoskeleton and interacts with profilin.

1996 • 130 citations

Activation of the Arp2/3 Complex by the Listeria ActA Protein

2001 • 129 citations

Wasp, the Drosophila Wiskott-Aldrich Syndrome Gene Homologue, Is Required for Cell Fate Decisions Mediated by Notch Signaling

2001 • 129 citations

EH Domain Proteins Pan1p and End3p Are Components of a Complex That Plays a Dual Role in Organization of the Cortical Actin Cytoskeleton and Endocytosis in Saccharomyces cerevisiae

1997 • 128 citations

Intracellular localization of the 55-kD actin-bundling protein in cultured cells: spatial relationships with actin, alpha-actinin, tropomyosin, and fimbrin.

1986 • 128 citations

Role for the Vaccinia Virus A36R Outer Envelope Protein in the Formation of Virus-Tipped Actin-Containing Microvilli and Cell-to-Cell Virus Spread

1998 • 128 citations

Rho family GTPases control entry of Shigella flexneri into epithelial cells but not intracellular motility

1999 • 127 citations

Actin filament nucleation by endosomes, lysosomes and secretory vesicles

2001 • 126 citations

Listeria Protein ActA Mimics WASP Family Proteins: It Activates Filament Barbed End Branching by Arp2/3 Complex

2001 • 126 citations

New yeast actin-like gene required late in the cell cycle

1992 • 124 citations

A class VII unconventional myosin is required for phagocytosis

1999 • 122 citations

Role of the actin bundling protein fascin in growth cone morphogenesis: Localization in filopodia and lamellipodia

2001 • 120 citations

Birefringence Imaging Directly Reveals Architectural Dynamics of Filamentous Actin in Living Growth Cones

1999 • 120 citations

The EH Network

1999 • 118 citations

A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast

2001 • 117 citations

Tyrosine phosphorylation is required for actin-based motility of vaccinia but not Listeria or Shigella

1999 • 112 citations

In vivo distribution and turnover of fluorescently labeled actin microinjected into human fibroblasts.

1979 • 110 citations

Novel form of actin-based motility transports bacteria on the surfaces of infected cells

1996 • 105 citations

Wasp, the Drosophila Wiskott-Aldrich Syndrome Gene Homologue, Is Required for Cell Fate Decisions Mediated by Notch Signaling

2001 • 103 citations

Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments

2001 • 100 citations

Arp2/3 Complex fromAcanthamoebaBinds Profilin and Cross-links Actin Filaments

1998 • 92 citations

Incorporation and turnover of biotin-labeled actin microinjected into fibroblastic cells: an immunoelectron microscopic study.

1989 • 91 citations

Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function.

1996 • 88 citations

The Rho GTPases in Macrophage Motility and Chemotaxis

1998 • 85 citations

Identification of act2, an essential gene in the fission yeast Schizosaccharomyces pombe that encodes a protein related to actin.

1992 • 85 citations

Insulin Stimulates Actin Comet Tails on Intracellular GLUT4-containing Compartments in Differentiated 3T3L1 Adipocytes

2001 • 80 citations

Mobility of filamentous actin in living cytoplasm.

1987 • 79 citations

Cloning and Expression of a Murine Fascin Homolog from Mouse Brain

1995 • 74 citations

Agents That Inhibit Rho, Rac, and Cdc42 Do Not Block Formation of Actin Pedestals in HeLa Cells Infected with Enteropathogenic Escherichia coli

1998 • 74 citations

Yeast as a Model System for Studying Endocytosis

2001 • 73 citations

Activation of Arp2/3 Complex by Wiskott-Aldrich Syndrome Protein Is Linked to Enhanced Binding of ATP to Arp2

2001 • 72 citations

Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerizationin Acanthamoeba extracts

1999 • 71 citations

The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling

2001 • 70 citations

Three actin cross-linking proteins, the 34 kDa actin-bundling protein, α-actinin and gelation factor (ABP-120), have both unique and redundant roles in the growth and development of Dictyostelium

1999 • 68 citations

Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants.

1996 • 65 citations

Reorganization of actin cytoskeleton at the growing end of the cleavage furrow of Xenopus egg during cytokinesis

2001 • 62 citations

The Verprolin-like Central (VC) Region of Wiskott-Aldrich Syndrome Protein Induces Arp2/3 Complex-dependent Actin Nucleation

2001 • 58 citations

Four-Dimensional Microscopic Analysis of the Filopodial Behavior of Primary Mesenchyme Cells during Gastrulation in the Sea Urchin Embryo

1995 • 57 citations

Subcellular distribution of rhodamine-actin microinjected into living fibroblastic cells.

1983 • 55 citations

Differential localization of α‐actinin and the 30 kD actin‐bundling protein in the cleavage furrow, phagocytic cup, and contractile vacuole of Dictyostelium discoideum

1994 • 55 citations

Mutations of arginine residues within the 146-KKRRK-150 motif of the ActA protein of Listeria monocytogenes abolish intracellular motility by interfering with the recruitment of the Arp2/3 complex

2000 • 53 citations

Rho Family Gtpase Cdc42 Is Essential for the Actin-Based Motility of Shigella in Mammalian Cells

1999 • 51 citations

Cdc42 is required for membrane dependent actin polymerization in vitro

1998 • 44 citations

Functional Interactions between the p35 Subunit of the Arp2/3 Complex and Calmodulin in Yeast

2000 • 44 citations

The Ras/Rac Guanine Nucleotide Exchange Factor Mammalian Son-of-sevenless Interacts with PACSIN 1/Syndapin I, a Regulator of Endocytosis and the Actin Cytoskeleton

2001 • 42 citations

Herbimycin A inhibits both dephosphorylation and translocation of cofilin induced by opsonized zymosan in macrophagelike U937 cells

1999 • 42 citations

Actin and Phosphoinositide Binding by the ActA Protein of the Bacterial Pathogen Listeria monocytogenes

1999 • 42 citations

Signaling Reaches to New Dimensions in Drosophila Imaginal Discs

2000 • 41 citations

Dynamic activity of the filopodia of sea urchin embryonic cells and their role in directed migration of the primary mesenchyme in vitro

1985 • 37 citations

The Role of Unconventional Myosins in Dictyostelium Endocytosis

2000 • 35 citations

Systematic mutational analysis of the amino‐terminal domain of the Listeria monocytogenes ActA protein reveals novel functions in actin‐based motility

2001 • 34 citations

The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches

1997 • 32 citations

ARP3β, the gene encoding a new human actin‐related protein, is alternatively spliced and predominantly expressed in brain neuronal cells

2000 • 32 citations

Cdc42 Facilitates Invasion but Not the Actin-Based Motility of Shigella

2002 • 31 citations

Listeria monocytogenes ActA protein interacts with phosphatidylinositol 4,5-bisphosphate in vitro

2000 • 29 citations

The connection of blastomeres of sea urchin embryos by filopodia

1968 • 17 citations

The actin-based motility of intracellularListeria monocytogenesis not controlled by small GTP-binding proteins of the Rho- and Ras-subfamilies

1999 • 11 citations

Role of the actin bundling protein fascin in growth cone morphogenesis: Localization in filopodia and lamellipodia

2001 • 7 citations

The actin-based motility of intracellular Listeria monocytogenes is not controlled by small GTP-binding proteins of the Rho- and Ras-subfamilies

1999 • 2 citations

Listeria monocytogenes ActA protein interacts with phosphatidylinositol 4,5-bisphosphate in vitroP.S. and D.A.S. contributed equally to this work.

2000 • 1 citations