Activation of Arp2/3 complex-mediated actin polymerization by cortactin

Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells

2000 • 1,471 citations

The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments

1998 • 1,388 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

1999 • 1,150 citations

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

1998 • 933 citations

Osteoclastic Bone Resorption by a Polarized Vacuolar Proton Pump

1989 • 864 citations

Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex

1999 • 771 citations

Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes

1997 • 598 citations

Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins

2000 • 558 citations

Activation of the Cdc42 Effector N-Wasp by the Shigella flexneri Icsa Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility

1999 • 513 citations

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.

1993 • 510 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

Cortactin Localization to Sites of Actin Assembly in Lamellipodia Requires Interactions with F-Actin and the Arp2/3 Complex

2000 • 410 citations

An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation

1999 • 355 citations

Influence of the C Terminus of Wiskott-Aldrich Syndrome Protein (WASp) and the Arp2/3 Complex on Actin Polymerization

1999 • 277 citations

The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes-a review

1995 • 276 citations

The Role of Tyrosine Phosphorylation of Cortactin in the Locomotion of Endothelial Cells

1998 • 271 citations

The Wiskott–Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex

1999 • 263 citations

Down-regulation of the Filamentous Actin Cross-linking Activity of Cortactin by Src-mediated Tyrosine Phosphorylation

1997 • 247 citations

The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins

2000 • 242 citations

Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein

1999 • 231 citations

Structure and function of the Arp2/3 complex

1999 • 230 citations

Structure, Subunit Topology, and Actin-binding Activity of the Arp2/3 Complex from Acanthamoeba

1997 • 224 citations

Three Regions within Acta Promote Arp2/3 Complex-Mediated Actin Nucleation and Listeria monocytogenes Motility

2000 • 185 citations

"Partly Folded" State, a New Equilibrium State of Protein Molecules: Four-State Guanidinium Chloride-Induced Unfolding of .beta.-Lactamase at Low Temperature

1994 • 182 citations

Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway.

1995 • 181 citations

The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites.

1993 • 165 citations

Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.

1989 • 149 citations

Direct Binding of the Verprolin-Homology Domain in N-WASP to Actin Is Essential for Cytoskeletal Reorganization

1998 • 141 citations

Mechanical Strain Induces pp60 Activation and Translocation to Cytoskeleton in Fetal Rat Lung Cells

1996 • 133 citations

Cell Shrinkage Regulates Src Kinases and Induces Tyrosine Phosphorylation of Cortactin, Independent of the Osmotic Regulation of Na+/H+ Exchangers

1999 • 111 citations

Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle.

1993 • 109 citations

An actin-nucleating activity in polymorphonuclear leukocytes is modulated by chemotactic peptides.

1986 • 103 citations

Growth Factor-dependent Phosphorylation of the Actin-binding Protein Cortactin Is Mediated by the Cytoplasmic Tyrosine Kinase FER

1998 • 93 citations

Infection with Chlamydia trachomatis alters the tyrosine phosphorylation and/or localization of several host cell proteins including cortactin

1997 • 91 citations

Differentiation dependent expression of tensin and cortactin in chicken osteoclasts

1995 • 67 citations

Tyrosine Phosphorylation of Cortactin Is Required for H2O2-mediated Injury of Human Endothelial Cells

2000 • 60 citations

Tyrosine Phosphorylation of Cortactin Associated with Syk Accompanies Thromboxane Analogue-induced Platelet Shape Change

1999 • 53 citations

Physical and Functional Association of Cortactin with Syk in Human Leukemic Cell Line K562

1996 • 45 citations

Interaction of Enteropathogenic or Enterohemorrhagic Escherichia coli with HeLa Cells Results in Translocation of Cortactin to the Bacterial Adherence Site

2000 • 44 citations

Proteolysis of Cortactin by Calpain in Platelets and In Vitro

2003 • 3 citations