A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Integrins.

1991 • 1,369 citations

Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.

1989 • 1,268 citations

Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

1989 • 724 citations

Enhancement of structural preservation and immunocytochemical staining in low temperature embedded pancreatic tissue.

1981 • 721 citations

Common themes in microbial pathogenicity

1989 • 701 citations

Comparative biology of intracellular parasitism

1985 • 442 citations

Coordinate regulation of virulence genes in Listeria monocytogenes requires the product of the prfA gene

1992 • 404 citations

Nucleotide sequence of the lecithinase operon of Listeria monocytogenes and possible role of lecithinase in cell-to-cell spread

1992 • 393 citations

Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulation

1987 • 327 citations

Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocytelike cell line Caco-2

1990 • 301 citations

Identification of a gene that positively regulates expression of listeriolysin, the major virulence factor of listeria monocytogenes.

1990 • 293 citations

Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication

1988 • 278 citations

Pleiotropic control of Listeria monocytogenes virulence factors by a gene that is autoregulated

1991 • 263 citations

Isolation of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread

1990 • 254 citations

virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence

1989 • 240 citations

A Bacillus cereus cytolytic determinant, cereolysin AB, which comprises the phospholipase C and sphingomyelinase genes: nucleotide sequence and genetic linkage

1989 • 165 citations

Bacterial entry into eukaryotic cells

1991 • 161 citations

Detection of a gene encoding a phosphatidylinositol‐specific phospholipase C that is co‐ordinately expressed with listeriolysin in Listeria monocytogenes

1991 • 160 citations

Genetic and Molecular Basis of Epithelial Cell Invasion by Shigella Species

1991 • 132 citations

Molecular cloning, sequencing, and identification of a metalloprotease gene from Listeria monocytogenes that is species specific and physically linked to the listeriolysin gene

1991 • 132 citations

Detection of listeriolysin, the thiol-dependent hemolysin in Listeria monocytogenes, Listeria ivanovii, and Listeria seeligeri

1989 • 123 citations

Identification of a new operon involved in Listeria monocytogenes virulence: its first gene encodes a protein homologous to bacterial metalloproteases

1991 • 122 citations

Transcriptional mapping and nucleotide sequence of the Listeria monocytogenes hlyA region reveal structural features that may be involved in regulation

1989 • 111 citations

Hemolytic and sphingomyelinase activities of Clostridium perfringens alpha-toxin are dependent on a domain homologous to that of an enzyme from the human arachidonic acid pathway

1991 • 103 citations

Cloning and sequencing of the gene encoding the phosphatidylcholine-preferring phospholipase C of Bacillus cereus

1988 • 100 citations

Intracellular spread of Shigella flexneri associated with the kcpA locus and a 140-kilodalton protein

1989 • 96 citations

Complete sequence of human vinculin and assignment of the gene to chromosome 10.

1990 • 72 citations

Acquired resistance to facultative intracellular bacteria: relationship between persistence, cross-reactivity at the T-cell level, and capacity to stimulate cellular immunity of different Listeria strains

1984 • 72 citations