Rho Family Gtpase Cdc42 Is Essential for the Actin-Based Motility of Shigella in Mammalian Cells

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

1994 • 1,053 citations

Reconstitution of actin-based motility of Listeria and Shigella using pure proteins

1999 • 968 citations

Fluorimetry study of N-(1-pyrenyl)iodoacetamide-labelled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosin.

1981 • 811 citations

S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

1998 • 804 citations

L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein

1992 • 790 citations

Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

1989 • 724 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

Fluorimetry Study of N‐(1‐Pyrenyl)iodoacetamide‐Labelled F‐Actin

1981 • 694 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes

1997 • 598 citations

A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion

1999 • 542 citations

The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization

1992 • 533 citations

Activation of the Cdc42 Effector N-Wasp by the Shigella flexneri Icsa Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility

1999 • 513 citations

Interaction of Human Arp2/3 Complex and the Listeria monocytogenes ActA Protein in Actin Filament Nucleation

1998 • 500 citations

Pyrene actin: documentation of the validity of a sensitive assay for actin polymerization

1983 • 472 citations

Actin-based motility of vaccinia virus

1995 • 426 citations

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

1997 • 414 citations

A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin.

1992 • 411 citations

Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling

1999 • 407 citations

Role of Proteins of the Ena/VASP Family in Actin-based Motility of Listeria monocytogenes

1999 • 356 citations

A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a

1986 • 312 citations

Requirement of CDC42 for Salmonella -Induced Cytoskeletal and Nuclear Responses

1996 • 303 citations

Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: bacterial factors, cellular ligands and signaling

1998 • 302 citations

Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement

1993 • 293 citations

A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells.

1995 • 272 citations

SCAR, a WASP-related Protein, Isolated as a Suppressor of Receptor Defects in Late Dictyostelium Development

1998 • 268 citations

A comparative study of the actin-based motilities of the pathogenic bacteria Listeria monocytogenes, Shigella flexneri and Rickettsia conorii

1999 • 257 citations

Bee1, a Yeast Protein with Homology to Wiscott-Aldrich Syndrome Protein, Is Critical for the Assembly of Cortical Actin Cytoskeleton

1997 • 252 citations

IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells

1999 • 251 citations

INTRACELLULAR PATHOGENS AND THE ACTIN CYTOSKELETON

1998 • 248 citations

Identification of Two Human WAVE/SCAR Homologues as General Actin Regulatory Molecules Which Associate with the Arp2/3 Complex

1999 • 242 citations

virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence

1989 • 240 citations

Directional actin polymerization associated with spotted fever group Rickettsia infection of Vero cells

1993 • 237 citations

Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri

1998 • 224 citations

Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts

1998 • 219 citations

Xenopus Actin Depolymerizing Factor/Cofilin (XAC) Is Responsible for the Turnover of Actin Filaments in Listeria monocytogenes Tails

1997 • 219 citations

Molecular alteration of the 140-megadalton plasmid associated with loss of virulence and Congo red binding activity in Shigella flexneri

1986 • 212 citations

Virulence-associated genetic regions comprising 31 kilobases of the 230-kilobase plasmid in Shigella flexneri 2a

1988 • 195 citations

[1] Purification of recombinant Rho/Rac/G25K from Escherichia coli

1995 • 190 citations

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread

1992 • 178 citations

The world according to Arp: regulation of actin nucleation by the Arp2/3 complex

1999 • 166 citations

CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway

1998 • 145 citations

Intracellular movements of Rickettsia conorii adn R. typhi based on actin polymerization

1992 • 143 citations

Rho-dependent membrane folding causes Shigella entry into epithelial cells.

1996 • 141 citations

Actin-based movement of Listeria monocytogenes: actin assembly results from the local maintenance of uncapped filament barbed ends at the bacterium surface.

1995 • 141 citations

Extracellular Transport of VirG Protein in Shigella

1995 • 128 citations

Rho family GTPases control entry of Shigella flexneri into epithelial cells but not intracellular motility

1999 • 127 citations

Tyrosine phosphorylation is required for actin-based motility of vaccinia but not Listeria or Shigella

1999 • 112 citations

Intercellular spread of Shigella flexneri through a monolayer mediated by membranous protrusions and associated with reorganization of the cytoskeletal protein vinculin

1991 • 110 citations

Unipolar reorganization of F-actin layer at bacterial division and bundling of actin filaments by plastin correlate with movement of Shigella flexneri within HeLa cells

1992 • 100 citations

rho, a Small GTP-Binding Protein, Is Essential for Shigella Invasion of Epithelial Cells

1997 • 97 citations

Identification and characterization of a chromosomal virulence gene, vacJ, required for intercellular spreading of Shigella flexneri

1994 • 97 citations

Functional Analysis of Shigella VirG Domains Essential for Interaction with Vinculin and Actin-based Motility

1996 • 93 citations

Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection

1999 • 90 citations

Control of reorganization of the actin cytoskeleton by Rho family small GTP-binding proteins in yeast

1998 • 69 citations

Vinculin Proteolysis Unmasks an ActA Homolog for Actin-based Shigella Motility

1997 • 68 citations

Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility.

1996 • 68 citations

Cleavage of Shigella surface protein VirG occurs at a specific site, but the secretion is not essential for intracellular spreading

1995 • 68 citations

In Vitro Reconstitution of Cortical Actin Assembly Sites in Budding Yeast

1997 • 62 citations

Cdc42 is required for membrane dependent actin polymerization in vitro

1998 • 44 citations

[11] Listeria monocytogenes-based assays for actin assembly factors

1998 • 19 citations